Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

Rong Jiang; Beverly H Brummett; Elizabeth R Hauser; Michael A Babyak; Ilene C Siegler; Abanish Singh; Arne Astrup; Oluf Pedersen; Torben Hansen; Claus Holst; Thorkild I A Sørensen; Redford B Williams

doi:10.1016/j.biopsycho.2013.02.006

Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

Rong Jiang, Beverly H Brummett, Elizabeth R Hauser, Michael A Babyak, Ilene C Siegler, Abanish Singh, Arne Astrup, Oluf Pedersen, Torben Hansen, Claus Holst, Thorkild I A Sørensen, Redford B Williams

8 Citations (Scopus)

Abstract

TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.

Original language	English
Journal	Biological Psychology
Volume	93
Issue number	1
Pages (from-to)	184-189
Number of pages	6
ISSN	0301-0511
DOIs	https://doi.org/10.1016/j.biopsycho.2013.02.006
Publication status	Published - Apr 2013

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Jiang, R., Brummett, B. H., Hauser, E. R., Babyak, M. A., Siegler, I. C., Singh, A., Astrup, A., Pedersen, O., Hansen, T., Holst, C., Sørensen, T. I. A., & Williams, R. B. (2013). Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples. Biological Psychology, 93(1), 184-189. https://doi.org/10.1016/j.biopsycho.2013.02.006

Jiang, R, Brummett, BH, Hauser, ER, Babyak, MA, Siegler, IC, Singh, A, Astrup, A, Pedersen, O, Hansen, T, Holst, C, Sørensen, TIA & Williams, RB 2013, 'Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples', Biological Psychology, vol. 93, no. 1, pp. 184-189. https://doi.org/10.1016/j.biopsycho.2013.02.006

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title = "Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples",

abstract = "TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.",

author = "Rong Jiang and Brummett, {Beverly H} and Hauser, {Elizabeth R} and Babyak, {Michael A} and Siegler, {Ilene C} and Abanish Singh and Arne Astrup and Oluf Pedersen and Torben Hansen and Claus Holst and S{\o}rensen, {Thorkild I A} and Williams, {Redford B}",

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T1 - Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

AU - Jiang, Rong

AU - Brummett, Beverly H

AU - Hauser, Elizabeth R

AU - Babyak, Michael A

AU - Siegler, Ilene C

AU - Singh, Abanish

AU - Astrup, Arne

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Holst, Claus

AU - Sørensen, Thorkild I A

AU - Williams, Redford B

N1 - CURIS 2013 NEXS 055

PY - 2013/4

Y1 - 2013/4

N2 - TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.

AB - TOMM40 SNP rs157580 has been associated with triglyceride levels in genome-wide association studies (GWAS). Chronic caregiving stress moderates the association between triglyceride levels and a nearby SNP rs439401 that is associated with triglyceride levels in GWAS. Here, we report data from two independent Caucasian samples (242 U.S. women and men; 466 Danish men) testing the hypothesis that chronic family stress also moderates the association between rs157580 and triglyceride levels. The interaction of rs157580 and family stress in predicting triglyceride levels was statistically significant in the U.S. sample (p=0.004) and marginally significant (p=0.075) in the Danish sample. The G allele of rs157580 was associated with increased triglyceride levels among family stressed cases in both samples compared with A/A cases, but not among controls. Chronic family stress moderates the association of rs157580 variants with triglyceride levels and should be taken into account for disease risk assessment and potential intervention.

U2 - 10.1016/j.biopsycho.2013.02.006

DO - 10.1016/j.biopsycho.2013.02.006

M3 - Journal article

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SN - 0301-0511

VL - 93

SP - 184

EP - 189

JO - Biological Psychology

JF - Biological Psychology

IS - 1

ER -

Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples

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