Chronic administration of epidermal growth factor to pigs induces growth, especially of the urinary tract with accumulation of epithelial glycoconjugates

Lars Vinter-Jensen; C O Juhl; Steen Seier Poulsen; Jens Christian Djurhuus; E Z Dajani; Ebba Nexø

Chronic administration of epidermal growth factor to pigs induces growth, especially of the urinary tract with accumulation of epithelial glycoconjugates

Lars Vinter-Jensen, C O Juhl, Steen Seier Poulsen, Jens Christian Djurhuus, E Z Dajani, Ebba Nexø

Endocrinology and Metabolism

9 Citations (Scopus)

Abstract

Epidermal growth factor (EGF) receptor hyperstimulation induced by systemically administered EGF or by the development of transgenic mice overexpressing transforming growth factor alpha (TGF alpha) or other EGF-related ligands is known to induce various effects, such as acceleration of developmental processes like incisor eruption, inhibition of gastric acid secretion, morphologic changes in the pancreas resembling pancreatitis, and malignancies in mammary glands and the liver. The present investigation was initiated to explore the effects of systemic EGF administration to the mature organism in a species with greater anatomic resemblance to humans than rodents.

Original language	English
Journal	Laboratory Investigation
Volume	73
Issue number	6
Pages (from-to)	788-93
Number of pages	6
ISSN	0023-6837
Publication status	Published - Dec 1995

Keywords

Animals
Digestive System
Epidermal Growth Factor
Female
Glycoconjugates
Hyperplasia
Lung
Male
Pancreas
Salivary Glands
Swine
Urinary Tract

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Chronic administration of epidermal growth factor to pigs induces growth, especially of the urinary tract with accumulation of epithelial glycoconjugates. / Vinter-Jensen, Lars; Juhl, C O; Poulsen, Steen Seier et al.

In: Laboratory Investigation, Vol. 73, No. 6, 12.1995, p. 788-93.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Chronic administration of epidermal growth factor to pigs induces growth, especially of the urinary tract with accumulation of epithelial glycoconjugates",

abstract = "Epidermal growth factor (EGF) receptor hyperstimulation induced by systemically administered EGF or by the development of transgenic mice overexpressing transforming growth factor alpha (TGF alpha) or other EGF-related ligands is known to induce various effects, such as acceleration of developmental processes like incisor eruption, inhibition of gastric acid secretion, morphologic changes in the pancreas resembling pancreatitis, and malignancies in mammary glands and the liver. The present investigation was initiated to explore the effects of systemic EGF administration to the mature organism in a species with greater anatomic resemblance to humans than rodents.",

keywords = "Animals, Digestive System, Epidermal Growth Factor, Female, Glycoconjugates, Hyperplasia, Lung, Male, Pancreas, Salivary Glands, Swine, Urinary Tract",

author = "Lars Vinter-Jensen and Juhl, {C O} and Poulsen, {Steen Seier} and Djurhuus, {Jens Christian} and Dajani, {E Z} and Ebba Nex{\o}",

year = "1995",

month = dec,

language = "English",

volume = "73",

pages = "788--93",

journal = "Laboratory Investigation",

issn = "0023-6837",

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T1 - Chronic administration of epidermal growth factor to pigs induces growth, especially of the urinary tract with accumulation of epithelial glycoconjugates

AU - Vinter-Jensen, Lars

AU - Juhl, C O

AU - Poulsen, Steen Seier

AU - Djurhuus, Jens Christian

AU - Dajani, E Z

AU - Nexø, Ebba

PY - 1995/12

Y1 - 1995/12

N2 - Epidermal growth factor (EGF) receptor hyperstimulation induced by systemically administered EGF or by the development of transgenic mice overexpressing transforming growth factor alpha (TGF alpha) or other EGF-related ligands is known to induce various effects, such as acceleration of developmental processes like incisor eruption, inhibition of gastric acid secretion, morphologic changes in the pancreas resembling pancreatitis, and malignancies in mammary glands and the liver. The present investigation was initiated to explore the effects of systemic EGF administration to the mature organism in a species with greater anatomic resemblance to humans than rodents.

AB - Epidermal growth factor (EGF) receptor hyperstimulation induced by systemically administered EGF or by the development of transgenic mice overexpressing transforming growth factor alpha (TGF alpha) or other EGF-related ligands is known to induce various effects, such as acceleration of developmental processes like incisor eruption, inhibition of gastric acid secretion, morphologic changes in the pancreas resembling pancreatitis, and malignancies in mammary glands and the liver. The present investigation was initiated to explore the effects of systemic EGF administration to the mature organism in a species with greater anatomic resemblance to humans than rodents.

KW - Animals

KW - Digestive System

KW - Epidermal Growth Factor

KW - Female

KW - Glycoconjugates

KW - Hyperplasia

KW - Lung

KW - Male

KW - Pancreas

KW - Salivary Glands

KW - Swine

KW - Urinary Tract

M3 - Journal article

C2 - 8558839

SN - 0023-6837

VL - 73

SP - 788

EP - 793

JO - Laboratory Investigation

JF - Laboratory Investigation

IS - 6

ER -

Chronic administration of epidermal growth factor to pigs induces growth, especially of the urinary tract with accumulation of epithelial glycoconjugates

Abstract

Keywords

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