Chromatin-modifying proteins in cancer.

Cathrine K Fog, Klaus T Jensen, Anders Henrik Lund

    31 Citations (Scopus)

    Abstract

    Chromatin-modifying proteins mold the genome into areas that are accessible for transcriptional activity and areas that are transcriptionally silent. This epigenetic gene regulation allows for different transcriptional programs to be conducted in different cell types at different timepoints-despite the fact that all cells in the organism contain the same genetic information. A large amount of data gathered over the last decades has demonstrated that deregulation of chromatin-modifying proteins is etiologically involved in the development and progression of cancer. Here we discuss how epigenetic alterations influence cancer development and review known cancer-associated alterations in chromatin-modifying proteins.
    Original languageEnglish
    JournalActa Pathologica Microbiologica et Immunologica Scandinavica
    Volume115
    Issue number10
    Pages (from-to)1060-89
    Number of pages29
    ISSN0903-4641
    DOIs
    Publication statusPublished - 2007

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