Chromatin challenges during DNA replication and repair.

Anja Groth; Walter Rocha; Alain Verreault; Geneviève Almouzni

doi:10.1016/j.cell.2007.01.030

Chromatin challenges during DNA replication and repair.

Anja Groth, Walter Rocha, Alain Verreault, Geneviève Almouzni

543 Citations (Scopus)

Abstract

Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair processes in the context of chromatin is a challenge, both in terms of accessibility and maintenance of chromatin organization. To meet the challenge of maintenance, cells have evolved efficient nucleosome-assembly pathways and chromatin-maturation mechanisms that reproduce chromatin organization in the wake of DNA replication and repair. The aim of this Review is to describe how these pathways operate and to highlight how the epigenetic landscape may be stably maintained even in the face of dramatic changes in chromatin structure.

Original language	English
Journal	Cell
Volume	128
Issue number	4
Pages (from-to)	721-33
Number of pages	12
ISSN	0092-8674
DOIs	https://doi.org/10.1016/j.cell.2007.01.030
Publication status	Published - 2007

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title = "Chromatin challenges during DNA replication and repair.",

abstract = "Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair processes in the context of chromatin is a challenge, both in terms of accessibility and maintenance of chromatin organization. To meet the challenge of maintenance, cells have evolved efficient nucleosome-assembly pathways and chromatin-maturation mechanisms that reproduce chromatin organization in the wake of DNA replication and repair. The aim of this Review is to describe how these pathways operate and to highlight how the epigenetic landscape may be stably maintained even in the face of dramatic changes in chromatin structure.",

author = "Anja Groth and Walter Rocha and Alain Verreault and Genevi{\`e}ve Almouzni",

note = "Keywords: Animals; Chromatin; DNA Repair; DNA Replication; Epigenesis, Genetic; Histones; Humans; Nucleosomes; Protein Processing, Post-Translational; Transcription Factors",

year = "2007",

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T1 - Chromatin challenges during DNA replication and repair.

AU - Groth, Anja

AU - Rocha, Walter

AU - Verreault, Alain

AU - Almouzni, Geneviève

N1 - Keywords: Animals; Chromatin; DNA Repair; DNA Replication; Epigenesis, Genetic; Histones; Humans; Nucleosomes; Protein Processing, Post-Translational; Transcription Factors

PY - 2007

Y1 - 2007

N2 - Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair processes in the context of chromatin is a challenge, both in terms of accessibility and maintenance of chromatin organization. To meet the challenge of maintenance, cells have evolved efficient nucleosome-assembly pathways and chromatin-maturation mechanisms that reproduce chromatin organization in the wake of DNA replication and repair. The aim of this Review is to describe how these pathways operate and to highlight how the epigenetic landscape may be stably maintained even in the face of dramatic changes in chromatin structure.

AB - Inheritance and maintenance of the DNA sequence and its organization into chromatin are central for eukaryotic life. To orchestrate DNA-replication and -repair processes in the context of chromatin is a challenge, both in terms of accessibility and maintenance of chromatin organization. To meet the challenge of maintenance, cells have evolved efficient nucleosome-assembly pathways and chromatin-maturation mechanisms that reproduce chromatin organization in the wake of DNA replication and repair. The aim of this Review is to describe how these pathways operate and to highlight how the epigenetic landscape may be stably maintained even in the face of dramatic changes in chromatin structure.

U2 - 10.1016/j.cell.2007.01.030

DO - 10.1016/j.cell.2007.01.030

M3 - Review

C2 - 17320509

SN - 0092-8674

VL - 128

SP - 721

EP - 733

JO - Cell

JF - Cell

IS - 4

ER -

Chromatin challenges during DNA replication and repair.

Abstract

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