Cholinergic dysfunction of heart, pupil, salivary glands, and urinary bladder in healthy volunteers during long-term treatment with clomipramine

Ellids Kristensen; Johannes Jacobsen; Ulla Bartels; Per Vestergaard

Cholinergic dysfunction of heart, pupil, salivary glands, and urinary bladder in healthy volunteers during long-term treatment with clomipramine

Ellids Kristensen, Johannes Jacobsen, Ulla Bartels, Per Vestergaard

25 Citations (Scopus)

Abstract

Cholinergic functions were studied in ten non-depressed healthy volunteers who were treated with 50 mg clomipramine daily for 3 weeks and subsequently with 100 mg daily for a further 3 weeks. Impairments in heart rate variation (HRV) at rest and standing, of the pupillary light response and of salivation were related to serum levels of clomipramine. Since reduction of HRV is closely related to dose (r = -0.83, P less than 10(-2] and is a better predictor of serum levels than the other measures examined, it is suggested that the easy obtainable function test of HRV at standing can be used as an estimate of over-all cholinergic dysfunction during treatment with tricyclic antidepressants.

Original language	English
Journal	Psychopharmacology
Volume	98
Issue number	3
Pages (from-to)	398-402
Number of pages	5
ISSN	0033-3158
Publication status	Published - 1989
Externally published	Yes

Cite this

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title = "Cholinergic dysfunction of heart, pupil, salivary glands, and urinary bladder in healthy volunteers during long-term treatment with clomipramine",

abstract = "Cholinergic functions were studied in ten non-depressed healthy volunteers who were treated with 50 mg clomipramine daily for 3 weeks and subsequently with 100 mg daily for a further 3 weeks. Impairments in heart rate variation (HRV) at rest and standing, of the pupillary light response and of salivation were related to serum levels of clomipramine. Since reduction of HRV is closely related to dose (r = -0.83, P less than 10(-2] and is a better predictor of serum levels than the other measures examined, it is suggested that the easy obtainable function test of HRV at standing can be used as an estimate of over-all cholinergic dysfunction during treatment with tricyclic antidepressants.",

author = "Ellids Kristensen and Johannes Jacobsen and Ulla Bartels and Per Vestergaard",

note = "Keywords: Adult; Clomipramine; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Humans; Male; Middle Aged; Parasympathetic Nervous System; Pupil; Salivary Glands; Urinary Bladder Paper id:: PMID: 2501816",

year = "1989",

language = "English",

volume = "98",

pages = "398--402",

journal = "Psychopharmacology",

issn = "0033-3158",

publisher = "Springer",

number = "3",

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TY - JOUR

T1 - Cholinergic dysfunction of heart, pupil, salivary glands, and urinary bladder in healthy volunteers during long-term treatment with clomipramine

AU - Kristensen, Ellids

AU - Jacobsen, Johannes

AU - Bartels, Ulla

AU - Vestergaard, Per

N1 - Keywords: Adult; Clomipramine; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Humans; Male; Middle Aged; Parasympathetic Nervous System; Pupil; Salivary Glands; Urinary Bladder Paper id:: PMID: 2501816

PY - 1989

Y1 - 1989

N2 - Cholinergic functions were studied in ten non-depressed healthy volunteers who were treated with 50 mg clomipramine daily for 3 weeks and subsequently with 100 mg daily for a further 3 weeks. Impairments in heart rate variation (HRV) at rest and standing, of the pupillary light response and of salivation were related to serum levels of clomipramine. Since reduction of HRV is closely related to dose (r = -0.83, P less than 10(-2] and is a better predictor of serum levels than the other measures examined, it is suggested that the easy obtainable function test of HRV at standing can be used as an estimate of over-all cholinergic dysfunction during treatment with tricyclic antidepressants.

AB - Cholinergic functions were studied in ten non-depressed healthy volunteers who were treated with 50 mg clomipramine daily for 3 weeks and subsequently with 100 mg daily for a further 3 weeks. Impairments in heart rate variation (HRV) at rest and standing, of the pupillary light response and of salivation were related to serum levels of clomipramine. Since reduction of HRV is closely related to dose (r = -0.83, P less than 10(-2] and is a better predictor of serum levels than the other measures examined, it is suggested that the easy obtainable function test of HRV at standing can be used as an estimate of over-all cholinergic dysfunction during treatment with tricyclic antidepressants.

M3 - Journal article

SN - 0033-3158

VL - 98

SP - 398

EP - 402

JO - Psychopharmacology

JF - Psychopharmacology

IS - 3

ER -

Cholinergic dysfunction of heart, pupil, salivary glands, and urinary bladder in healthy volunteers during long-term treatment with clomipramine

Abstract

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