Children with allergic and nonallergic rhinitis have a similar risk of asthma

Bo Lund Krogsgaard Chawes; Klaus Bønnelykke; Eskil Kreiner-Møller; Hans Bisgaard

doi:10.1016/j.jaci.2010.06.026

Children with allergic and nonallergic rhinitis have a similar risk of asthma

Bo Lund Krogsgaard Chawes, Klaus Bønnelykke, Eskil Kreiner-Møller, Hans Bisgaard

76 Citations (Scopus)

Abstract

Background: Both allergic and nonallergic rhinitis have been associated with increased prevalence of asthma. Objective: To characterize asthma and intermediary asthma endpoints in young children with allergic and nonallergic rhinitis. Methods: Thirty-eight 7-year-old children with allergic rhinitis, 67 with nonallergic rhinitis, and 185 without rhinitis from the Copenhagen Prospective Study on Asthma in Childhood birth cohort were compared for prevalence of asthma, eczema, food sensitization, filaggrin null-mutations, total IgE, blood eosinophil count, fractional exhaled nitric oxide (FeNO), lung function, and bronchial responsiveness. Results: Children with allergic rhinitis compared with asymptomatic controls had increased prevalence of asthma (21% vs 5%; P = .002), food sensitization (47% vs 13%; P < .001), and eczema (66% vs 43%; P = .01) and increased total IgE (155 kU/L vs 41 kU/L; P < .001), blood eosinophil count (0.46 × 10⁹/L vs 0.30 × 10 ⁹/L; P = .01), FeNO (15.9 ppb vs 6.6 ppb; P < .001), and bronchial hyperresponsiveness (23% vs 9%; P = .008). Filaggrin null-mutations were associated with allergic rhinitis (odds ratio, 3.3; 95% CI, 1.3-8.3) but did not modify these associations. Children with nonallergic rhinitis also had increased asthma prevalence (20% vs 5%; P = .001) but showed no association with filaggrin null-mutations, eczema, food sensitization, total IgE, blood eosinophil count, FeNO, or bronchial responsiveness. Conclusion: Asthma is similarly associated with allergic and nonallergic rhinitis, suggesting a link between upper and lower airways beyond allergy associated inflammation. Only children with allergic rhinitis had increased bronchial responsiveness and elevated FeNO, suggesting different endotypes of asthma symptoms in young children with allergic and nonallergic rhinitis.

Original language	English
Journal	Journal of Allergy and Clinical Immunology
Volume	126
Issue number	3
Pages (from-to)	567-73.e1-8
ISSN	0091-6749
DOIs	https://doi.org/10.1016/j.jaci.2010.06.026
Publication status	Published - 1 Sept 2010

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10.1016/j.jaci.2010.06.026

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title = "Children with allergic and nonallergic rhinitis have a similar risk of asthma",

abstract = "Background: Both allergic and nonallergic rhinitis have been associated with increased prevalence of asthma. Objective: To characterize asthma and intermediary asthma endpoints in young children with allergic and nonallergic rhinitis. Methods: Thirty-eight 7-year-old children with allergic rhinitis, 67 with nonallergic rhinitis, and 185 without rhinitis from the Copenhagen Prospective Study on Asthma in Childhood birth cohort were compared for prevalence of asthma, eczema, food sensitization, filaggrin null-mutations, total IgE, blood eosinophil count, fractional exhaled nitric oxide (FeNO), lung function, and bronchial responsiveness. Results: Children with allergic rhinitis compared with asymptomatic controls had increased prevalence of asthma (21% vs 5%; P = .002), food sensitization (47% vs 13%; P < .001), and eczema (66% vs 43%; P = .01) and increased total IgE (155 kU/L vs 41 kU/L; P < .001), blood eosinophil count (0.46 × 109/L vs 0.30 × 10 9/L; P = .01), FeNO (15.9 ppb vs 6.6 ppb; P < .001), and bronchial hyperresponsiveness (23% vs 9%; P = .008). Filaggrin null-mutations were associated with allergic rhinitis (odds ratio, 3.3; 95% CI, 1.3-8.3) but did not modify these associations. Children with nonallergic rhinitis also had increased asthma prevalence (20% vs 5%; P = .001) but showed no association with filaggrin null-mutations, eczema, food sensitization, total IgE, blood eosinophil count, FeNO, or bronchial responsiveness. Conclusion: Asthma is similarly associated with allergic and nonallergic rhinitis, suggesting a link between upper and lower airways beyond allergy associated inflammation. Only children with allergic rhinitis had increased bronchial responsiveness and elevated FeNO, suggesting different endotypes of asthma symptoms in young children with allergic and nonallergic rhinitis.",

author = "Chawes, {Bo Lund Krogsgaard} and Klaus B{\o}nnelykke and Eskil Kreiner-M{\o}ller and Hans Bisgaard",

year = "2010",

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doi = "10.1016/j.jaci.2010.06.026",

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TY - JOUR

T1 - Children with allergic and nonallergic rhinitis have a similar risk of asthma

AU - Chawes, Bo Lund Krogsgaard

AU - Bønnelykke, Klaus

AU - Kreiner-Møller, Eskil

AU - Bisgaard, Hans

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Background: Both allergic and nonallergic rhinitis have been associated with increased prevalence of asthma. Objective: To characterize asthma and intermediary asthma endpoints in young children with allergic and nonallergic rhinitis. Methods: Thirty-eight 7-year-old children with allergic rhinitis, 67 with nonallergic rhinitis, and 185 without rhinitis from the Copenhagen Prospective Study on Asthma in Childhood birth cohort were compared for prevalence of asthma, eczema, food sensitization, filaggrin null-mutations, total IgE, blood eosinophil count, fractional exhaled nitric oxide (FeNO), lung function, and bronchial responsiveness. Results: Children with allergic rhinitis compared with asymptomatic controls had increased prevalence of asthma (21% vs 5%; P = .002), food sensitization (47% vs 13%; P < .001), and eczema (66% vs 43%; P = .01) and increased total IgE (155 kU/L vs 41 kU/L; P < .001), blood eosinophil count (0.46 × 109/L vs 0.30 × 10 9/L; P = .01), FeNO (15.9 ppb vs 6.6 ppb; P < .001), and bronchial hyperresponsiveness (23% vs 9%; P = .008). Filaggrin null-mutations were associated with allergic rhinitis (odds ratio, 3.3; 95% CI, 1.3-8.3) but did not modify these associations. Children with nonallergic rhinitis also had increased asthma prevalence (20% vs 5%; P = .001) but showed no association with filaggrin null-mutations, eczema, food sensitization, total IgE, blood eosinophil count, FeNO, or bronchial responsiveness. Conclusion: Asthma is similarly associated with allergic and nonallergic rhinitis, suggesting a link between upper and lower airways beyond allergy associated inflammation. Only children with allergic rhinitis had increased bronchial responsiveness and elevated FeNO, suggesting different endotypes of asthma symptoms in young children with allergic and nonallergic rhinitis.

AB - Background: Both allergic and nonallergic rhinitis have been associated with increased prevalence of asthma. Objective: To characterize asthma and intermediary asthma endpoints in young children with allergic and nonallergic rhinitis. Methods: Thirty-eight 7-year-old children with allergic rhinitis, 67 with nonallergic rhinitis, and 185 without rhinitis from the Copenhagen Prospective Study on Asthma in Childhood birth cohort were compared for prevalence of asthma, eczema, food sensitization, filaggrin null-mutations, total IgE, blood eosinophil count, fractional exhaled nitric oxide (FeNO), lung function, and bronchial responsiveness. Results: Children with allergic rhinitis compared with asymptomatic controls had increased prevalence of asthma (21% vs 5%; P = .002), food sensitization (47% vs 13%; P < .001), and eczema (66% vs 43%; P = .01) and increased total IgE (155 kU/L vs 41 kU/L; P < .001), blood eosinophil count (0.46 × 109/L vs 0.30 × 10 9/L; P = .01), FeNO (15.9 ppb vs 6.6 ppb; P < .001), and bronchial hyperresponsiveness (23% vs 9%; P = .008). Filaggrin null-mutations were associated with allergic rhinitis (odds ratio, 3.3; 95% CI, 1.3-8.3) but did not modify these associations. Children with nonallergic rhinitis also had increased asthma prevalence (20% vs 5%; P = .001) but showed no association with filaggrin null-mutations, eczema, food sensitization, total IgE, blood eosinophil count, FeNO, or bronchial responsiveness. Conclusion: Asthma is similarly associated with allergic and nonallergic rhinitis, suggesting a link between upper and lower airways beyond allergy associated inflammation. Only children with allergic rhinitis had increased bronchial responsiveness and elevated FeNO, suggesting different endotypes of asthma symptoms in young children with allergic and nonallergic rhinitis.

U2 - 10.1016/j.jaci.2010.06.026

DO - 10.1016/j.jaci.2010.06.026

M3 - Journal article

SN - 0091-6749

VL - 126

SP - 567-73.e1-8

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

IS - 3

ER -

Children with allergic and nonallergic rhinitis have a similar risk of asthma

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