Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer

Bahir Aldulaymi; Ib J Christensen; György Sölétormos; Per Jess; Svend Erik Nielsen; Søren Laurberg; Nils Brünner; Hans J Nielsen

Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer

Bahir Aldulaymi, Ib J Christensen, György Sölétormos, Per Jess, Svend Erik Nielsen, Søren Laurberg, Nils Brünner, Hans J Nielsen

9 Citations (Scopus)

Abstract

BACKGROUND: Preoperative biomarkers serum CEA and plasma TIMP-1 have been shown to have prognostic and predictive value in patients with colorectal cancer. The aim of the present study was to evaluate the possible impact of chemoradiotherapy (CRT) on preoperative biomarker levels in patients with rectal cancer. PATIENTS AND METHODS: Thirty-three patients with rectal cancer were prospectively included. The patients received CRT for 6-8 weeks. Blood samples were collected before CRT (pre-CRT) and preoperatively (post-CRT). RESULTS: Median CEA was 3.5 (range 0.6-36.1) µg/l and 2.4 (range 0.0-10.2) µg/l (p=0.002) and median plasma TIMP-1 was 132.1 (range 77.8-342.7) µg/l and 140.0 (range 82.6-440.9) µg/l (p=0.04) in the pre- and post-CRT measurements, respectively. CONCLUSION: CRT induced a significant decrease in serum CEA and increase in plasma TIMP-1 levels. Therefore, the preoperative biomarker levels may be affected by treatments received before blood sample collection. Translation of results of preoperative biomarkers needs to take such facts into consideration.

Original language	English
Journal	Anticancer Research
Volume	30
Issue number	11
Pages (from-to)	4755-9
Number of pages	5
ISSN	0250-7005
Publication status	Published - 1 Nov 2010

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http://www.ncbi.nlm.nih.gov/pubmed?term=Chemoradiation-induced%20changes%20in%20serum%20CEA%20and%20plasma%20TIMP-1%20in%20patients%20with%20locally%20advanced%20rectal%20cancerPublikation%3A%20Forskning%20-%20peer%20review%20%E2%80%BA%20Tidsskriftartikel

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Aldulaymi, B., Christensen, I. J., Sölétormos, G., Jess, P., Nielsen, S. E., Laurberg, S., Brünner, N., & Nielsen, H. J. (2010). Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer. Anticancer Research, 30(11), 4755-9. http://www.ncbi.nlm.nih.gov/pubmed?term=Chemoradiation-induced%20changes%20in%20serum%20CEA%20and%20plasma%20TIMP-1%20in%20patients%20with%20locally%20advanced%20rectal%20cancerPublikation%3A%20Forskning%20-%20peer%20review%20%E2%80%BA%20Tidsskriftartikel

Aldulaymi, B, Christensen, IJ, Sölétormos, G, Jess, P, Nielsen, SE, Laurberg, S, Brünner, N & Nielsen, HJ 2010, 'Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer', Anticancer Research, vol. 30, no. 11, pp. 4755-9. <http://www.ncbi.nlm.nih.gov/pubmed?term=Chemoradiation-induced%20changes%20in%20serum%20CEA%20and%20plasma%20TIMP-1%20in%20patients%20with%20locally%20advanced%20rectal%20cancerPublikation%3A%20Forskning%20-%20peer%20review%20%E2%80%BA%20Tidsskriftartikel>

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title = "Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer",

abstract = "BACKGROUND: Preoperative biomarkers serum CEA and plasma TIMP-1 have been shown to have prognostic and predictive value in patients with colorectal cancer. The aim of the present study was to evaluate the possible impact of chemoradiotherapy (CRT) on preoperative biomarker levels in patients with rectal cancer. PATIENTS AND METHODS: Thirty-three patients with rectal cancer were prospectively included. The patients received CRT for 6-8 weeks. Blood samples were collected before CRT (pre-CRT) and preoperatively (post-CRT). RESULTS: Median CEA was 3.5 (range 0.6-36.1) µg/l and 2.4 (range 0.0-10.2) µg/l (p=0.002) and median plasma TIMP-1 was 132.1 (range 77.8-342.7) µg/l and 140.0 (range 82.6-440.9) µg/l (p=0.04) in the pre- and post-CRT measurements, respectively. CONCLUSION: CRT induced a significant decrease in serum CEA and increase in plasma TIMP-1 levels. Therefore, the preoperative biomarker levels may be affected by treatments received before blood sample collection. Translation of results of preoperative biomarkers needs to take such facts into consideration.",

author = "Bahir Aldulaymi and Christensen, {Ib J} and Gy{\"o}rgy S{\"o}l{\'e}tormos and Per Jess and Nielsen, {Svend Erik} and S{\o}ren Laurberg and Nils Br{\"u}nner and Nielsen, {Hans J}",

year = "2010",

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language = "English",

volume = "30",

pages = "4755--9",

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TY - JOUR

T1 - Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer

AU - Aldulaymi, Bahir

AU - Christensen, Ib J

AU - Sölétormos, György

AU - Jess, Per

AU - Nielsen, Svend Erik

AU - Laurberg, Søren

AU - Brünner, Nils

AU - Nielsen, Hans J

PY - 2010/11/1

Y1 - 2010/11/1

N2 - BACKGROUND: Preoperative biomarkers serum CEA and plasma TIMP-1 have been shown to have prognostic and predictive value in patients with colorectal cancer. The aim of the present study was to evaluate the possible impact of chemoradiotherapy (CRT) on preoperative biomarker levels in patients with rectal cancer. PATIENTS AND METHODS: Thirty-three patients with rectal cancer were prospectively included. The patients received CRT for 6-8 weeks. Blood samples were collected before CRT (pre-CRT) and preoperatively (post-CRT). RESULTS: Median CEA was 3.5 (range 0.6-36.1) µg/l and 2.4 (range 0.0-10.2) µg/l (p=0.002) and median plasma TIMP-1 was 132.1 (range 77.8-342.7) µg/l and 140.0 (range 82.6-440.9) µg/l (p=0.04) in the pre- and post-CRT measurements, respectively. CONCLUSION: CRT induced a significant decrease in serum CEA and increase in plasma TIMP-1 levels. Therefore, the preoperative biomarker levels may be affected by treatments received before blood sample collection. Translation of results of preoperative biomarkers needs to take such facts into consideration.

AB - BACKGROUND: Preoperative biomarkers serum CEA and plasma TIMP-1 have been shown to have prognostic and predictive value in patients with colorectal cancer. The aim of the present study was to evaluate the possible impact of chemoradiotherapy (CRT) on preoperative biomarker levels in patients with rectal cancer. PATIENTS AND METHODS: Thirty-three patients with rectal cancer were prospectively included. The patients received CRT for 6-8 weeks. Blood samples were collected before CRT (pre-CRT) and preoperatively (post-CRT). RESULTS: Median CEA was 3.5 (range 0.6-36.1) µg/l and 2.4 (range 0.0-10.2) µg/l (p=0.002) and median plasma TIMP-1 was 132.1 (range 77.8-342.7) µg/l and 140.0 (range 82.6-440.9) µg/l (p=0.04) in the pre- and post-CRT measurements, respectively. CONCLUSION: CRT induced a significant decrease in serum CEA and increase in plasma TIMP-1 levels. Therefore, the preoperative biomarker levels may be affected by treatments received before blood sample collection. Translation of results of preoperative biomarkers needs to take such facts into consideration.

M3 - Journal article

SN - 0250-7005

VL - 30

SP - 4755

EP - 4759

JO - Anticancer Research

JF - Anticancer Research

IS - 11

ER -

Chemoradiation-induced changes in serum CEA and plasma TIMP-1 in patients with locally advanced rectal cancer

Abstract

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