Chemokine stromal cell-derived factor 1alpha activates basophils by means of CXCR4

T Jinquan, H H Jacobi, C Jing, C M Reimert, S Quan, S Dissing, Lars K. Poulsen, P S Skov

37 Citations (Scopus)

Abstract

The CXC chemokine receptor 4 (CXCR4) is predominantly expressed on inactivated naive T lymphocytes, B lymphocytes, dendritic cells, and endothelial cells. CXC chemokine stromal cell-derived factor 1alpha (SDF-1alpha) is the only known ligand for CXCR4. To date, the CXCR4 expression and function of SDF-1alpha in basophils are unknown.
Original languageEnglish
JournalThe Journal of allergy and clinical immunology
Volume106
Issue number2
Pages (from-to)313-20
Number of pages8
ISSN0091-6749
DOIs
Publication statusPublished - Aug 2000

Keywords

  • Basophils
  • Calcium
  • Chemokine CXCL12
  • Chemokines, CXC
  • Chemotaxis
  • Histamine Release
  • Humans
  • RNA, Messenger
  • Receptors, CXCR4
  • Stromal Cells

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