Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

Kasper Huus; Svend Havelund; Helle B Olsen; Marco van de Weert; Sven Frokjaer

doi:10.1007/s11095-006-9098-y

Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

Kasper Huus, Svend Havelund, Helle B Olsen, Marco van de Weert, Sven Frokjaer

28 Citations (Scopus)

Abstract

To study the correlation between the thermal and chemical stability of insulin formulations with various insulin hexamer ligands.

Original language	English
Journal	Pharmaceutical Research
Volume	23
Issue number	11
Pages (from-to)	2611-20
Number of pages	10
ISSN	0724-8741
DOIs	https://doi.org/10.1007/s11095-006-9098-y
Publication status	Published - Nov 2006

Keywords

Calorimetry, Differential Scanning
Drug Stability
Hot Temperature
Insulin
Ligands
Thiocyanates
Zinc

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10.1007/s11095-006-9098-y

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title = "Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer",

abstract = "To study the correlation between the thermal and chemical stability of insulin formulations with various insulin hexamer ligands.",

keywords = "Calorimetry, Differential Scanning, Drug Stability, Hot Temperature, Insulin, Ligands, Thiocyanates, Zinc",

author = "Kasper Huus and Svend Havelund and Olsen, {Helle B} and {van de Weert}, Marco and Sven Frokjaer",

year = "2006",

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doi = "10.1007/s11095-006-9098-y",

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T1 - Chemical and thermal stability of insulin

T2 - effects of zinc and ligand binding to the insulin zinc-hexamer

AU - Huus, Kasper

AU - Havelund, Svend

AU - Olsen, Helle B

AU - van de Weert, Marco

AU - Frokjaer, Sven

PY - 2006/11

Y1 - 2006/11

N2 - To study the correlation between the thermal and chemical stability of insulin formulations with various insulin hexamer ligands.

AB - To study the correlation between the thermal and chemical stability of insulin formulations with various insulin hexamer ligands.

KW - Calorimetry, Differential Scanning

KW - Drug Stability

KW - Hot Temperature

KW - Insulin

KW - Ligands

KW - Thiocyanates

KW - Zinc

U2 - 10.1007/s11095-006-9098-y

DO - 10.1007/s11095-006-9098-y

M3 - Journal article

C2 - 16969698

SN - 0724-8741

VL - 23

SP - 2611

EP - 2620

JO - Pharmaceutical Research

JF - Pharmaceutical Research

IS - 11

ER -

Chemical and thermal stability of insulin: effects of zinc and ligand binding to the insulin zinc-hexamer

Abstract

Keywords

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