Characterization of the hydrodynamics in a miniaturized dissolution apparatus

Kristoffer Enøe Johansson; Jakob Plum; Majid Mosleh; Cecilie Maria Madsen; Thomas Rades; Anette Müllertz

doi:10.1016/j.xphs.2017.11.022

Characterization of the hydrodynamics in a miniaturized dissolution apparatus

Kristoffer Enøe Johansson, Jakob Plum, Majid Mosleh, Cecilie Maria Madsen, Thomas Rades, Anette Müllertz

2 Citations (Scopus)

Abstract

The hydrodynamics of a miniaturized dissolution apparatus was characterized using computational fluid dynamics simulations and analyzed in relation to the biorelevance and robustness of measurements of drug dissolution and precipitation kinetics from supersaturated drug solutions. The effect of using 3 different agitator geometries operated at 50, 100, 150, and 200 rpm as well as different positioning of an UV probe in the vessel was systematically evaluated. The computational fluid dynamics simulations were validated using a particle streak velocimetry experiment. The results show that the choice of agitator geometry influences the hydrodynamics of the system and indicates that an off-center probe position may result in more robust measurements. Furthermore, the study shows that the agitator geometry has a significant effect on supersaturation studies due to differences in the hydrodynamic shear produced by the agitator.

Original language	English
Journal	Journal of Pharmaceutical Sciences
Volume	107
Issue number	4
Pages (from-to)	1095-1103
Number of pages	9
ISSN	0022-3549
DOIs	https://doi.org/10.1016/j.xphs.2017.11.022
Publication status	Published - Apr 2018

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10.1016/j.xphs.2017.11.022

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title = "Characterization of the hydrodynamics in a miniaturized dissolution apparatus",

abstract = "The hydrodynamics of a miniaturized dissolution apparatus was characterized using computational fluid dynamics simulations and analyzed in relation to the biorelevance and robustness of measurements of drug dissolution and precipitation kinetics from supersaturated drug solutions. The effect of using 3 different agitator geometries operated at 50, 100, 150, and 200 rpm as well as different positioning of an UV probe in the vessel was systematically evaluated. The computational fluid dynamics simulations were validated using a particle streak velocimetry experiment. The results show that the choice of agitator geometry influences the hydrodynamics of the system and indicates that an off-center probe position may result in more robust measurements. Furthermore, the study shows that the agitator geometry has a significant effect on supersaturation studies due to differences in the hydrodynamic shear produced by the agitator.",

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author = "Johansson, {Kristoffer En{\o}e} and Jakob Plum and Majid Mosleh and Madsen, {Cecilie Maria} and Thomas Rades and Anette M{\"u}llertz",

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T1 - Characterization of the hydrodynamics in a miniaturized dissolution apparatus

AU - Johansson, Kristoffer Enøe

AU - Plum, Jakob

AU - Mosleh, Majid

AU - Madsen, Cecilie Maria

AU - Rades, Thomas

AU - Müllertz, Anette

PY - 2018/4

Y1 - 2018/4

N2 - The hydrodynamics of a miniaturized dissolution apparatus was characterized using computational fluid dynamics simulations and analyzed in relation to the biorelevance and robustness of measurements of drug dissolution and precipitation kinetics from supersaturated drug solutions. The effect of using 3 different agitator geometries operated at 50, 100, 150, and 200 rpm as well as different positioning of an UV probe in the vessel was systematically evaluated. The computational fluid dynamics simulations were validated using a particle streak velocimetry experiment. The results show that the choice of agitator geometry influences the hydrodynamics of the system and indicates that an off-center probe position may result in more robust measurements. Furthermore, the study shows that the agitator geometry has a significant effect on supersaturation studies due to differences in the hydrodynamic shear produced by the agitator.

AB - The hydrodynamics of a miniaturized dissolution apparatus was characterized using computational fluid dynamics simulations and analyzed in relation to the biorelevance and robustness of measurements of drug dissolution and precipitation kinetics from supersaturated drug solutions. The effect of using 3 different agitator geometries operated at 50, 100, 150, and 200 rpm as well as different positioning of an UV probe in the vessel was systematically evaluated. The computational fluid dynamics simulations were validated using a particle streak velocimetry experiment. The results show that the choice of agitator geometry influences the hydrodynamics of the system and indicates that an off-center probe position may result in more robust measurements. Furthermore, the study shows that the agitator geometry has a significant effect on supersaturation studies due to differences in the hydrodynamic shear produced by the agitator.

KW - Journal Article

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DO - 10.1016/j.xphs.2017.11.022

M3 - Journal article

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VL - 107

SP - 1095

EP - 1103

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

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ER -

Characterization of the hydrodynamics in a miniaturized dissolution apparatus

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