Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS).

M E Durkin; A C Jäger; T S Khurana; F C Nielsen; R Albrechtsen; U M Wewer

Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS).

M E Durkin, A C Jäger, T S Khurana, F C Nielsen, R Albrechtsen, U M Wewer

Department of Biomedical Sciences

4 Citations (Scopus)

Abstract

The laminin beta2 chain is an important constituent of certain kidney and muscle basement membranes. We have generated a detailed physical map of a 110-kb genomic DNA segment surrounding the human laminin beta2 chain gene (LAMB2) on chromosome 3p21.3-->p21.2, a region paralogous with the chromosome 7q22-->q31 region that contains the laminin beta1 chain gene locus (LAMB1). Several CpG islands and a novel polymorphic microsatellite marker (D3S4594) were identified. The 3' end of LAMB2 lies 16 kb from the 5' end of the glutaminyl tRNA synthetase gene (QARS). About 20 kb upstream of LAMB2 we found a gene encoding a transcribed, non-processed LAMB2-like pseudogene (LAMB2L). The sequence of 1.75 kb of genomic DNA at the 3' end of LAMB2L was similar to exons 8-12 of the laminin beta2 chain gene. The LAMB2L-LAMB2-QARS cluster lies telomeric to the gene encoding the laminin-binding protein dystroglycan (DAG1).

Original language	English
Journal	Cytogenetic and Genome Research
Volume	84
Issue number	3-4
Pages (from-to)	173-8
Number of pages	5
ISSN	1424-8581
Publication status	Published - 1999

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Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS). / Durkin, M E; Jäger, A C; Khurana, T S et al.
In: Cytogenetic and Genome Research, Vol. 84, No. 3-4, 1999, p. 173-8.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS).",

abstract = "The laminin beta2 chain is an important constituent of certain kidney and muscle basement membranes. We have generated a detailed physical map of a 110-kb genomic DNA segment surrounding the human laminin beta2 chain gene (LAMB2) on chromosome 3p21.3-->p21.2, a region paralogous with the chromosome 7q22-->q31 region that contains the laminin beta1 chain gene locus (LAMB1). Several CpG islands and a novel polymorphic microsatellite marker (D3S4594) were identified. The 3' end of LAMB2 lies 16 kb from the 5' end of the glutaminyl tRNA synthetase gene (QARS). About 20 kb upstream of LAMB2 we found a gene encoding a transcribed, non-processed LAMB2-like pseudogene (LAMB2L). The sequence of 1.75 kb of genomic DNA at the 3' end of LAMB2L was similar to exons 8-12 of the laminin beta2 chain gene. The LAMB2L-LAMB2-QARS cluster lies telomeric to the gene encoding the laminin-binding protein dystroglycan (DAG1).",

author = "Durkin, {M E} and J{\"a}ger, {A C} and Khurana, {T S} and Nielsen, {F C} and R Albrechtsen and Wewer, {U M}",

note = "Keywords: Amino Acid Sequence; Amino Acyl-tRNA Synthetases; Animals; Base Sequence; Chromosomes, Artificial, Yeast; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Cloning, Molecular; CpG Islands; Cytoskeletal Proteins; Dystroglycans; Evolution, Molecular; Exons; Genetic Markers; Genome, Human; Humans; Introns; Laminin; Linkage (Genetics); Membrane Glycoproteins; Mice; Microsatellite Repeats; Molecular Sequence Data; Physical Chromosome Mapping; Pseudogenes",

year = "1999",

language = "English",

volume = "84",

pages = "173--8",

journal = "Cytogenetic and Genome Research",

issn = "1424-8581",

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}

TY - JOUR

T1 - Characterization of the human laminin beta2 chain locus (LAMB2): linkage to a gene containing a nonprocessed, transcribed LAMB2-like pseudogene (LAMB2L) and to the gene encoding glutaminyl tRNA synthetase (QARS).

AU - Durkin, M E

AU - Jäger, A C

AU - Khurana, T S

AU - Nielsen, F C

AU - Albrechtsen, R

AU - Wewer, U M

N1 - Keywords: Amino Acid Sequence; Amino Acyl-tRNA Synthetases; Animals; Base Sequence; Chromosomes, Artificial, Yeast; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Cloning, Molecular; CpG Islands; Cytoskeletal Proteins; Dystroglycans; Evolution, Molecular; Exons; Genetic Markers; Genome, Human; Humans; Introns; Laminin; Linkage (Genetics); Membrane Glycoproteins; Mice; Microsatellite Repeats; Molecular Sequence Data; Physical Chromosome Mapping; Pseudogenes

PY - 1999

Y1 - 1999

N2 - The laminin beta2 chain is an important constituent of certain kidney and muscle basement membranes. We have generated a detailed physical map of a 110-kb genomic DNA segment surrounding the human laminin beta2 chain gene (LAMB2) on chromosome 3p21.3-->p21.2, a region paralogous with the chromosome 7q22-->q31 region that contains the laminin beta1 chain gene locus (LAMB1). Several CpG islands and a novel polymorphic microsatellite marker (D3S4594) were identified. The 3' end of LAMB2 lies 16 kb from the 5' end of the glutaminyl tRNA synthetase gene (QARS). About 20 kb upstream of LAMB2 we found a gene encoding a transcribed, non-processed LAMB2-like pseudogene (LAMB2L). The sequence of 1.75 kb of genomic DNA at the 3' end of LAMB2L was similar to exons 8-12 of the laminin beta2 chain gene. The LAMB2L-LAMB2-QARS cluster lies telomeric to the gene encoding the laminin-binding protein dystroglycan (DAG1).

AB - The laminin beta2 chain is an important constituent of certain kidney and muscle basement membranes. We have generated a detailed physical map of a 110-kb genomic DNA segment surrounding the human laminin beta2 chain gene (LAMB2) on chromosome 3p21.3-->p21.2, a region paralogous with the chromosome 7q22-->q31 region that contains the laminin beta1 chain gene locus (LAMB1). Several CpG islands and a novel polymorphic microsatellite marker (D3S4594) were identified. The 3' end of LAMB2 lies 16 kb from the 5' end of the glutaminyl tRNA synthetase gene (QARS). About 20 kb upstream of LAMB2 we found a gene encoding a transcribed, non-processed LAMB2-like pseudogene (LAMB2L). The sequence of 1.75 kb of genomic DNA at the 3' end of LAMB2L was similar to exons 8-12 of the laminin beta2 chain gene. The LAMB2L-LAMB2-QARS cluster lies telomeric to the gene encoding the laminin-binding protein dystroglycan (DAG1).

M3 - Journal article

C2 - 10393422

SN - 1424-8581

VL - 84

SP - 173

EP - 178

JO - Cytogenetic and Genome Research

JF - Cytogenetic and Genome Research

IS - 3-4

ER -