Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair

TY - JOUR

T1 - Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair

AU - Christensen, Søren T

AU - Pedersen, Stine F

AU - Satir, Peter

AU - Veland, Iben R

AU - Schneider, Linda

PY - 2008

Y1 - 2008

N2 - Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRalpha). We also consider how the primary cilium and the centrosome interact with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration.

AB - Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRalpha). We also consider how the primary cilium and the centrosome interact with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration.

U2 - 10.1016/S0070-2153(08)00810-7

DO - 10.1016/S0070-2153(08)00810-7

M3 - Journal article

C2 - 19147009

SN - 0070-2153

VL - 85

SP - 261

EP - 301

JO - Current Topics in Developmental Biology

JF - Current Topics in Developmental Biology

ER -