Abstract
Objective: To investigate effects of long-term treatment of oral Carvedilol on ventricular myocytes membrane capacitance in HMI.
Methods: 30 rabbits were randomly assigned in three groups: HMI group, ligation of circumflex coronary artery; Carvedilol group, with operation the same as HMI group, and administration of oral Carvedilol 0.33 mg/kg×3 months beginning on the day of operation; Sham group, left thoracotomy with no coronary artery ligation. 3 months after surgery, rabbits were harvested. Myocytes were isolated by enzymatic method. The cell membrane capacitance was recorded by using the whole cell patch clamp technique.
Results: The membrane capacitance of myocytes in CVD group was reduced significantly as compared with those in HMI group which was larger than those in Sham group (P<0.05).
Conclusion: Long-term treatment of oral Carvedilol may reverse the increase of ventricular myocytes membrane capacitance.
Methods: 30 rabbits were randomly assigned in three groups: HMI group, ligation of circumflex coronary artery; Carvedilol group, with operation the same as HMI group, and administration of oral Carvedilol 0.33 mg/kg×3 months beginning on the day of operation; Sham group, left thoracotomy with no coronary artery ligation. 3 months after surgery, rabbits were harvested. Myocytes were isolated by enzymatic method. The cell membrane capacitance was recorded by using the whole cell patch clamp technique.
Results: The membrane capacitance of myocytes in CVD group was reduced significantly as compared with those in HMI group which was larger than those in Sham group (P<0.05).
Conclusion: Long-term treatment of oral Carvedilol may reverse the increase of ventricular myocytes membrane capacitance.
| Original language | Chinese |
|---|---|
| Journal | Tongji Daxue Xuebao (Yixue Ban) |
| Volume | 26 |
| Issue number | 4 |
| Pages (from-to) | 21-23 |
| Number of pages | 4 |
| Publication status | Published - 2005 |