TY - JOUR
T1 - Changes in lung function of HIV-infected patients
T2 - a 4.5-year follow-up study
AU - Kristoffersen, Ulrik Sloth
AU - Lebech, Anne-Mette
AU - Mortensen, Jann
AU - Gerstoft, Jan
AU - Borgwardt, Henrik Gutte
AU - Kjaer, Andreas
N1 - © 2012 The Authors Clinical Physiology and Functional Imaging © 2012 Scandinavian Society of Clinical Physiology and Nuclear Medicine.
PY - 2012/7
Y1 - 2012/7
N2 - Objective: To investigate the development of lung function in HIV-infected patients. Methods: In a prospective cohort study, 88 HIV-infected patients had a lung function test performed and 63 patients (72%) had their LFT repeated with a median follow-up period of 4·4 years. Forty-eight per cent were smokers, and at the re-examination, 97% were on combination antiretroviral therapy. Results: Carbon monoxide diffusion capacity was reduced and decreased over time in both smokers and non-smokers. Alveolar volume decreased and forced vital capacity increased similarly in both smokers and non-smokers. No changes were observed in forced expiratory volume or peak flow, but smokers had reduced values compared with those of the non-smokers at both examinations. FEV1/FVC was reduced especially in smokers and declined in both smokers and non-smokers. Conclusions: Carbon monoxide diffusion capacity is reduced in HIV-infected patients and seems to decline over time. Additionally, signs of obstructive lung disease are present in HIV-infected patients and seem to increase over time, although only modestly.
AB - Objective: To investigate the development of lung function in HIV-infected patients. Methods: In a prospective cohort study, 88 HIV-infected patients had a lung function test performed and 63 patients (72%) had their LFT repeated with a median follow-up period of 4·4 years. Forty-eight per cent were smokers, and at the re-examination, 97% were on combination antiretroviral therapy. Results: Carbon monoxide diffusion capacity was reduced and decreased over time in both smokers and non-smokers. Alveolar volume decreased and forced vital capacity increased similarly in both smokers and non-smokers. No changes were observed in forced expiratory volume or peak flow, but smokers had reduced values compared with those of the non-smokers at both examinations. FEV1/FVC was reduced especially in smokers and declined in both smokers and non-smokers. Conclusions: Carbon monoxide diffusion capacity is reduced in HIV-infected patients and seems to decline over time. Additionally, signs of obstructive lung disease are present in HIV-infected patients and seem to increase over time, although only modestly.
U2 - 10.1111/j.1475-097x.2012.01124.x
DO - 10.1111/j.1475-097x.2012.01124.x
M3 - Journal article
SN - 1475-0961
VL - 32
SP - 288
EP - 295
JO - Clinical Physiology and Functional Imaging
JF - Clinical Physiology and Functional Imaging
IS - 4
ER -
