Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes: A longitudinal study of the general population

Morten Dahl; Anne Tybjaerg-Hansen; Peter Lange; Jørgen Vestbo; Børge G Nordestgaard

Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes: A longitudinal study of the general population

Morten Dahl, Anne Tybjaerg-Hansen, Peter Lange, Jørgen Vestbo, Børge G Nordestgaard

Section of Social Medicine

124 Citations (Scopus)

Abstract

A deteriorating effect of severe alpha(1)-antitrypsin deficiency (ZZ genotype) on lung function is well known, whereas the role of intermediate deficiency (MZ genotype) remains uncertain.

Original language	English
Journal	Annals of Internal Medicine
Volume	136
Issue number	4
Pages (from-to)	270-9
Number of pages	10
ISSN	0003-4819
Publication status	Published - 19 Feb 2002

Keywords

Adult
Blood Proteins
Cystic Fibrosis Transmembrane Conductance Regulator
Denmark
Female
Follow-Up Studies
Forced Expiratory Volume
Heterozygote
Hospitalization
Humans
Male
Mutation
Pulmonary Disease, Chronic Obstructive
Questionnaires
Regression Analysis
Smoking
Spirometry
alpha 1-Antitrypsin Deficiency

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Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes : A longitudinal study of the general population. / Dahl, Morten; Tybjaerg-Hansen, Anne ; Lange, Peter et al.

In: Annals of Internal Medicine, Vol. 136, No. 4, 19.02.2002, p. 270-9.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Vestbo, Jørgen

AU - Nordestgaard, Børge G

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KW - Cystic Fibrosis Transmembrane Conductance Regulator

KW - Denmark

KW - Female

KW - Follow-Up Studies

KW - Forced Expiratory Volume

KW - Heterozygote

KW - Hospitalization

KW - Humans

KW - Male

KW - Mutation

KW - Pulmonary Disease, Chronic Obstructive

KW - Questionnaires

KW - Regression Analysis

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Change in lung function and morbidity from chronic obstructive pulmonary disease in alpha1-antitrypsin MZ heterozygotes: A longitudinal study of the general population

Abstract

Keywords

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