TY - JOUR
T1 - Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines
AU - Barfod, Lea
AU - Kemp, Kåre
AU - Hansen, Majbritt
AU - Kharazmi, Arsalan
N1 - Keywords: Antiparasitic Agents; Cell Division; Chalcone; Chalcones; Cytokines; Dose-Response Relationship, Drug; Flow Cytometry; Gene Expression Regulation; Glycyrrhiza; Humans; Lipopolysaccharides; Medicine, Chinese Traditional; Phytohemagglutinins; Phytotherapy; T-Lymphocytes; Tetradecanoylphorbol Acetate
PY - 2002
Y1 - 2002
N2 - Licochalcone A (LicA), an oxygenated chalcone, has been shown to inhibit the growth of both parasites and bacteria. In this study, we investigated the effect of LicA and four synthetic analogues on the activity of human peripheral blood mononuclear cell proliferation and cytokine production. Four out of five chalcones tested inhibited the proliferation of lymphocytes measured by thymidine incorporation and by flow cytometry. The production of pro- and anti-inflammatory cytokines from monocytes and T cells was also inhibited by four of five chalcones. Furthermore, intracellular detection of cytokines revealed that the chalcones inhibited the production rather than the release of the cytokines. Taken together, these results indicate that LicA and some analogues may have immunomodulatory effects, and may thus be candidates not only as anti-microbial agents, but also for the treatment of other types of diseases.
AB - Licochalcone A (LicA), an oxygenated chalcone, has been shown to inhibit the growth of both parasites and bacteria. In this study, we investigated the effect of LicA and four synthetic analogues on the activity of human peripheral blood mononuclear cell proliferation and cytokine production. Four out of five chalcones tested inhibited the proliferation of lymphocytes measured by thymidine incorporation and by flow cytometry. The production of pro- and anti-inflammatory cytokines from monocytes and T cells was also inhibited by four of five chalcones. Furthermore, intracellular detection of cytokines revealed that the chalcones inhibited the production rather than the release of the cytokines. Taken together, these results indicate that LicA and some analogues may have immunomodulatory effects, and may thus be candidates not only as anti-microbial agents, but also for the treatment of other types of diseases.
M3 - Journal article
C2 - 11962733
SN - 1567-5769
VL - 2
SP - 545
EP - 555
JO - International Immunopharmacology
JF - International Immunopharmacology
IS - 4
ER -
