CGRP in human models of primary headaches

Håkan Ashina; Henrik Winther Schytz; Messoud Ashina

doi:10.1177/0333102416684344

CGRP in human models of primary headaches

Håkan Ashina, Henrik Winther Schytz, Messoud Ashina

Department of Clinical Medicine

9 Citations (Scopus)

Abstract

Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.

Original language	English
Journal	Cephalalgia : an international journal of headache
Volume	38
Issue number	2
Pages (from-to)	353-360
Number of pages	8
ISSN	0333-1024
DOIs	https://doi.org/10.1177/0333102416684344
Publication status	Published - 1 Feb 2018

Keywords

Analgesics/pharmacology
Biomarkers/metabolism
Calcitonin Gene-Related Peptide/antagonists & inhibitors
Cluster Headache/diagnosis
Humans
Migraine Disorders/diagnosis
Tension-Type Headache/diagnosis

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title = "CGRP in human models of primary headaches",

abstract = "Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.",

keywords = "Analgesics/pharmacology, Biomarkers/metabolism, Calcitonin Gene-Related Peptide/antagonists & inhibitors, Cluster Headache/diagnosis, Humans, Migraine Disorders/diagnosis, Tension-Type Headache/diagnosis",

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T1 - CGRP in human models of primary headaches

AU - Ashina, Håkan

AU - Schytz, Henrik Winther

AU - Ashina, Messoud

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N2 - Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.

AB - Objective To review the role of CGRP in human models of primary headaches and to discuss methodological aspects and future directions. Discussion Provocation experiments demonstrated a heterogeneous CGRP migraine response in migraine patients. Conflicting CGRP plasma results in the provocation experiments are likely due to assay variation; therefore, proper validation and standardization of an assay is needed. To what extent CGRP is involved in tension-type headache and cluster headache is unknown. Conclusion Human models of primary headaches have elucidated the role of CGRP in headache pathophysiology and sparked great interest in developing new treatment strategies using CGRP antagonists and antibodies. Future studies applying more refined human experimental models should identify biomarkers of CGRP-induced primary headache and reveal whether CGRP provocation experiments could be used to predict efficacy of CGRP antagonists in migraine patients.

KW - Analgesics/pharmacology

KW - Biomarkers/metabolism

KW - Calcitonin Gene-Related Peptide/antagonists & inhibitors

KW - Cluster Headache/diagnosis

KW - Humans

KW - Migraine Disorders/diagnosis

KW - Tension-Type Headache/diagnosis

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DO - 10.1177/0333102416684344

M3 - Review

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SN - 0800-1952

VL - 38

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EP - 360

JO - Cephalalgia, Supplement

JF - Cephalalgia, Supplement

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CGRP in human models of primary headaches

Abstract

Keywords

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