Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study

P N Nielsen; P S Skov; Lars K. Poulsen; M Schmelz; L J Petersen

Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study

P N Nielsen, P S Skov, Lars K. Poulsen, M Schmelz, L J Petersen

25 Citations (Scopus)

Abstract

Recent reports have indicated cetirizine, a potent H(1)-receptor antagonist, to possess a number of anti-inflammatory effects, e.g. inhibition of mast cell degranulation and inhibition of leucocyte migration and activation.

Original language	English
Journal	Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Volume	31
Issue number	9
Pages (from-to)	1378-84
Number of pages	7
ISSN	0954-7894
Publication status	Published - Sept 2001

Keywords

Administration, Cutaneous
Adult
Allergens
Antitussive Agents
Cetirizine
Codeine
Cross-Over Studies
Dose-Response Relationship, Drug
Double-Blind Method
Drug Eruptions
Eosinophils
Female
Histamine
Histamine H1 Antagonists
Histamine Release
Humans
Hypersensitivity, Delayed
Hypersensitivity, Immediate
Inflammation Mediators
Male
Prostaglandin D2
Skin
Skin Tests
Time Factors

Cite this

Nielsen, P. N., Skov, P. S., Poulsen, L. K., Schmelz, M., & Petersen, L. J. (2001). Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 31(9), 1378-84.

Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study. / Nielsen, P N; Skov, P S; Poulsen, Lars K. et al.

In: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, Vol. 31, No. 9, 09.2001, p. 1378-84.

Research output: Contribution to journal › Journal article › Research › peer-review

Nielsen, PN, Skov, PS, Poulsen, LK, Schmelz, M & Petersen, LJ 2001, 'Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study', Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, vol. 31, no. 9, pp. 1378-84.

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abstract = "Recent reports have indicated cetirizine, a potent H(1)-receptor antagonist, to possess a number of anti-inflammatory effects, e.g. inhibition of mast cell degranulation and inhibition of leucocyte migration and activation.",

keywords = "Administration, Cutaneous, Adult, Allergens, Antitussive Agents, Cetirizine, Codeine, Cross-Over Studies, Dose-Response Relationship, Drug, Double-Blind Method, Drug Eruptions, Eosinophils, Female, Histamine, Histamine H1 Antagonists, Histamine Release, Humans, Hypersensitivity, Delayed, Hypersensitivity, Immediate, Inflammation Mediators, Male, Prostaglandin D2, Skin, Skin Tests, Time Factors",

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AU - Nielsen, P N

AU - Skov, P S

AU - Poulsen, Lars K.

AU - Schmelz, M

AU - Petersen, L J

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KW - Adult

KW - Allergens

KW - Antitussive Agents

KW - Cetirizine

KW - Codeine

KW - Cross-Over Studies

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Drug Eruptions

KW - Eosinophils

KW - Female

KW - Histamine

KW - Histamine H1 Antagonists

KW - Histamine Release

KW - Humans

KW - Hypersensitivity, Delayed

KW - Hypersensitivity, Immediate

KW - Inflammation Mediators

KW - Male

KW - Prostaglandin D2

KW - Skin

KW - Skin Tests

KW - Time Factors

M3 - Journal article

C2 - 11591187

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VL - 31

SP - 1378

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JO - Clinical Allergy

JF - Clinical Allergy

IS - 9

ER -

Cetirizine inhibits skin reactions but not mediator release in immediate and developing late-phase allergic cutaneous reactions. A double-blind, placebo-controlled study

Abstract

Keywords

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