Cesarean Delivery and Body Mass Index at 6 Months and Into Childhood

Rebecca Kofod Vinding; Tobias Steen Sejersen; Bo L Chawes; Klaus Bønnelykke; Thora Buhl; Hans Bisgaard; Jakob Stokholm

doi:10.1542/peds.2016-4066

Cesarean Delivery and Body Mass Index at 6 Months and Into Childhood

Rebecca Kofod Vinding, Tobias Steen Sejersen, Bo L Chawes, Klaus Bønnelykke, Thora Buhl, Hans Bisgaard, Jakob Stokholm

Department of Clinical Medicine

13 Citations (Scopus)

Abstract

BACKGROUND AND OBJECTIVES: The prevalence of cesarean delivery (CD) is rising worldwide, and so is childhood obesity. Studies have shown associations between these factors. We examined the development of BMI from birth through childhood to determine whether CDs were associated with differences in growth and obesity.

METHODS: Term children from the birth cohorts Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and COPSAC2010 were included. Height, length, and weight measurements were collected prospectively until 5 years in COPSAC2010 and until 13 years in COPSAC2000. Dual-energy x-ray absorptiometry (DXA) scans were performed at 3.5 and 7 years. Information on relevant covariates were verified during clinical visits. Analyses were adjusted for covariates associating with CD.

RESULTS: In COPSAC2010, 20% (N = 138/673) of the children were delivered by CD; 49% were girls. In COPSAC2000, 19% (N = 76/393) were delivered by CD; 51% were girls. Children delivered by CD had a higher mean BMI at 6 months compared with those delivered vaginally: COPSAC2010 β-coefficient, .41 (95% confidence interval [CI], .12 to .69), P = .01; COPSAC2000 β-coefficient, .16 (95% CI, -.11 to .68), P = .16; and meta-analysis β-coefficient, .37 (95% CI, .14 to .60), P = .002. There were no differences in BMI trajectory between the 2 groups by 5 and 13 years, nor cross-sectional BMI at 5 and 13 years, nor in fat percentages from DXA scans.

CONCLUSIONS: Children delivered by CD had a higher BMI at 6 months of age, but this difference did not track into later childhood. Our study does not support the hypothesis that CD leads to later overweight.

Original language	English
Article number	e20164066
Journal	Pediatrics
Volume	139
Issue number	6
Number of pages	12
ISSN	0031-4005
DOIs	https://doi.org/10.1542/peds.2016-4066
Publication status	Published - Jun 2017

Keywords

Adolescent
Body Mass Index
Cesarean Section
Child, Preschool
Female
Humans
Infant
Male
Overweight
Prospective Studies
Reference Values
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Cesarean Delivery and Body Mass Index at 6 Months and Into Childhood",

abstract = "BACKGROUND AND OBJECTIVES: The prevalence of cesarean delivery (CD) is rising worldwide, and so is childhood obesity. Studies have shown associations between these factors. We examined the development of BMI from birth through childhood to determine whether CDs were associated with differences in growth and obesity.METHODS: Term children from the birth cohorts Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and COPSAC2010 were included. Height, length, and weight measurements were collected prospectively until 5 years in COPSAC2010 and until 13 years in COPSAC2000. Dual-energy x-ray absorptiometry (DXA) scans were performed at 3.5 and 7 years. Information on relevant covariates were verified during clinical visits. Analyses were adjusted for covariates associating with CD.RESULTS: In COPSAC2010, 20% (N = 138/673) of the children were delivered by CD; 49% were girls. In COPSAC2000, 19% (N = 76/393) were delivered by CD; 51% were girls. Children delivered by CD had a higher mean BMI at 6 months compared with those delivered vaginally: COPSAC2010 β-coefficient, .41 (95% confidence interval [CI], .12 to .69), P = .01; COPSAC2000 β-coefficient, .16 (95% CI, -.11 to .68), P = .16; and meta-analysis β-coefficient, .37 (95% CI, .14 to .60), P = .002. There were no differences in BMI trajectory between the 2 groups by 5 and 13 years, nor cross-sectional BMI at 5 and 13 years, nor in fat percentages from DXA scans.CONCLUSIONS: Children delivered by CD had a higher BMI at 6 months of age, but this difference did not track into later childhood. Our study does not support the hypothesis that CD leads to later overweight.",

keywords = "Adolescent, Body Mass Index, Cesarean Section, Child, Preschool, Female, Humans, Infant, Male, Overweight, Prospective Studies, Reference Values, Journal Article",

author = "Vinding, {Rebecca Kofod} and Sejersen, {Tobias Steen} and Chawes, {Bo L} and Klaus B{\o}nnelykke and Thora Buhl and Hans Bisgaard and Jakob Stokholm",

note = "Copyright {\textcopyright} 2017 by the American Academy of Pediatrics.",

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language = "English",

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T1 - Cesarean Delivery and Body Mass Index at 6 Months and Into Childhood

AU - Vinding, Rebecca Kofod

AU - Sejersen, Tobias Steen

AU - Chawes, Bo L

AU - Bønnelykke, Klaus

AU - Buhl, Thora

AU - Bisgaard, Hans

AU - Stokholm, Jakob

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Y1 - 2017/6

N2 - BACKGROUND AND OBJECTIVES: The prevalence of cesarean delivery (CD) is rising worldwide, and so is childhood obesity. Studies have shown associations between these factors. We examined the development of BMI from birth through childhood to determine whether CDs were associated with differences in growth and obesity.METHODS: Term children from the birth cohorts Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and COPSAC2010 were included. Height, length, and weight measurements were collected prospectively until 5 years in COPSAC2010 and until 13 years in COPSAC2000. Dual-energy x-ray absorptiometry (DXA) scans were performed at 3.5 and 7 years. Information on relevant covariates were verified during clinical visits. Analyses were adjusted for covariates associating with CD.RESULTS: In COPSAC2010, 20% (N = 138/673) of the children were delivered by CD; 49% were girls. In COPSAC2000, 19% (N = 76/393) were delivered by CD; 51% were girls. Children delivered by CD had a higher mean BMI at 6 months compared with those delivered vaginally: COPSAC2010 β-coefficient, .41 (95% confidence interval [CI], .12 to .69), P = .01; COPSAC2000 β-coefficient, .16 (95% CI, -.11 to .68), P = .16; and meta-analysis β-coefficient, .37 (95% CI, .14 to .60), P = .002. There were no differences in BMI trajectory between the 2 groups by 5 and 13 years, nor cross-sectional BMI at 5 and 13 years, nor in fat percentages from DXA scans.CONCLUSIONS: Children delivered by CD had a higher BMI at 6 months of age, but this difference did not track into later childhood. Our study does not support the hypothesis that CD leads to later overweight.

AB - BACKGROUND AND OBJECTIVES: The prevalence of cesarean delivery (CD) is rising worldwide, and so is childhood obesity. Studies have shown associations between these factors. We examined the development of BMI from birth through childhood to determine whether CDs were associated with differences in growth and obesity.METHODS: Term children from the birth cohorts Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) and COPSAC2010 were included. Height, length, and weight measurements were collected prospectively until 5 years in COPSAC2010 and until 13 years in COPSAC2000. Dual-energy x-ray absorptiometry (DXA) scans were performed at 3.5 and 7 years. Information on relevant covariates were verified during clinical visits. Analyses were adjusted for covariates associating with CD.RESULTS: In COPSAC2010, 20% (N = 138/673) of the children were delivered by CD; 49% were girls. In COPSAC2000, 19% (N = 76/393) were delivered by CD; 51% were girls. Children delivered by CD had a higher mean BMI at 6 months compared with those delivered vaginally: COPSAC2010 β-coefficient, .41 (95% confidence interval [CI], .12 to .69), P = .01; COPSAC2000 β-coefficient, .16 (95% CI, -.11 to .68), P = .16; and meta-analysis β-coefficient, .37 (95% CI, .14 to .60), P = .002. There were no differences in BMI trajectory between the 2 groups by 5 and 13 years, nor cross-sectional BMI at 5 and 13 years, nor in fat percentages from DXA scans.CONCLUSIONS: Children delivered by CD had a higher BMI at 6 months of age, but this difference did not track into later childhood. Our study does not support the hypothesis that CD leads to later overweight.

KW - Adolescent

KW - Body Mass Index

KW - Cesarean Section

KW - Child, Preschool

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Overweight

KW - Prospective Studies

KW - Reference Values

KW - Journal Article

U2 - 10.1542/peds.2016-4066

DO - 10.1542/peds.2016-4066

M3 - Journal article

C2 - 28814549

SN - 0031-4005

VL - 139

JO - Pediatrics

JF - Pediatrics

IS - 6

M1 - e20164066

ER -

Cesarean Delivery and Body Mass Index at 6 Months and Into Childhood

Abstract

Keywords

UN SDGs

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