Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males

T Seifert; P Rasmussen; P Brassard; P H Homann; M Wissenberg; P Nordby; B Stallknecht; N H Secher; H B Nielsen

doi:10.1152/ajpregu.00277.2009

Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males

T Seifert, P Rasmussen, P Brassard, P H Homann, M Wissenberg, P Nordby, B Stallknecht, N H Secher, H B Nielsen

Torekov Group

31 Citations (Scopus)

Abstract

Endurance training improves muscular and cardiovascular fitness, but the effect on cerebral oxygenation and metabolism remains unknown. We hypothesized that 3 mo of endurance training would reduce cerebral carbohydrate uptake with maintained cerebral oxygenation during submaximal exercise. Healthy overweight males were included in a randomized, controlled study (training: n = 10; control: n = 7). Arterial and internal jugular venous catheterization was used to determine concentration differences for oxygen, glucose, and lactate across the brain and the oxygen-carbohydrate index [molar uptake of oxygen/(glucose + (1/2) lactate); OCI], changes in mitochondrial oxygen tension (DeltaP(Mito)O(2)) and the cerebral metabolic rate of oxygen (CMRO(2)) were calculated. For all subjects, resting OCI was higher at the 3-mo follow-up (6.3 +/- 1.3 compared with 4.7 +/- 0.9 at baseline, mean +/- SD; P < 0.05) and coincided with a lower plasma epinephrine concentration (P < 0.05). Cerebral adaptations to endurance training manifested when exercising at 70% of maximal oxygen uptake (approximately 211 W). Before training, both OCI (3.9 +/- 0.9) and DeltaP(Mito)O(2) (-22 mmHg) decreased (P < 0.05), whereas CMRO(2) increased by 79 +/- 53 micromol x 100 x g(-1) min(-1) (P < 0.05). At the 3-mo follow-up, OCI (4.9 +/- 1.0) and DeltaP(Mito)O(2) (-7 +/- 13 mmHg) did not decrease significantly from rest and when compared with values before training (P < 0.05), CMRO(2) did not increase. This study demonstrates that endurance training attenuates the cerebral metabolic response to submaximal exercise, as reflected in a lower carbohydrate uptake and maintained cerebral oxygenation.

Original language	English
Journal	American Journal of Physiology: Regulatory, Integrative and Comparative Physiology
Volume	297
Issue number	3
Pages (from-to)	R867-76
ISSN	0363-6119
DOIs	https://doi.org/10.1152/ajpregu.00277.2009
Publication status	Published - 2009

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Seifert, T., Rasmussen, P., Brassard, P., Homann, P. H., Wissenberg, M., Nordby, P., Stallknecht, B., Secher, N. H., & Nielsen, H. B. (2009). Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 297(3), R867-76. https://doi.org/10.1152/ajpregu.00277.2009

Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males. / Seifert, T; Rasmussen, P; Brassard, P et al.

In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol. 297, No. 3, 2009, p. R867-76.

Research output: Contribution to journal › Journal article › Research › peer-review

Seifert, T, Rasmussen, P, Brassard, P, Homann, PH, Wissenberg, M, Nordby, P, Stallknecht, B, Secher, NH & Nielsen, HB 2009, 'Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males', American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol. 297, no. 3, pp. R867-76. https://doi.org/10.1152/ajpregu.00277.2009

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title = "Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males",

abstract = "Endurance training improves muscular and cardiovascular fitness, but the effect on cerebral oxygenation and metabolism remains unknown. We hypothesized that 3 mo of endurance training would reduce cerebral carbohydrate uptake with maintained cerebral oxygenation during submaximal exercise. Healthy overweight males were included in a randomized, controlled study (training: n = 10; control: n = 7). Arterial and internal jugular venous catheterization was used to determine concentration differences for oxygen, glucose, and lactate across the brain and the oxygen-carbohydrate index [molar uptake of oxygen/(glucose + (1/2) lactate); OCI], changes in mitochondrial oxygen tension (DeltaP(Mito)O(2)) and the cerebral metabolic rate of oxygen (CMRO(2)) were calculated. For all subjects, resting OCI was higher at the 3-mo follow-up (6.3 +/- 1.3 compared with 4.7 +/- 0.9 at baseline, mean +/- SD; P < 0.05) and coincided with a lower plasma epinephrine concentration (P < 0.05). Cerebral adaptations to endurance training manifested when exercising at 70% of maximal oxygen uptake (approximately 211 W). Before training, both OCI (3.9 +/- 0.9) and DeltaP(Mito)O(2) (-22 mmHg) decreased (P < 0.05), whereas CMRO(2) increased by 79 +/- 53 micromol x 100 x g(-1) min(-1) (P < 0.05). At the 3-mo follow-up, OCI (4.9 +/- 1.0) and DeltaP(Mito)O(2) (-7 +/- 13 mmHg) did not decrease significantly from rest and when compared with values before training (P < 0.05), CMRO(2) did not increase. This study demonstrates that endurance training attenuates the cerebral metabolic response to submaximal exercise, as reflected in a lower carbohydrate uptake and maintained cerebral oxygenation.",

author = "T Seifert and P Rasmussen and P Brassard and Homann, {P H} and M Wissenberg and P Nordby and B Stallknecht and Secher, {N H} and Nielsen, {H B}",

note = "Keywords: Adaptation, Physiological; Adult; Blood Glucose; Brain; Cerebrovascular Circulation; Epinephrine; Exercise; Exercise Tolerance; Hemodynamics; Humans; Lactic Acid; Male; Mitochondria; Norepinephrine; Overweight; Oxygen; Oxygen Consumption; Physical Endurance; Time Factors; Ultrasonography, Doppler, Transcranial",

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doi = "10.1152/ajpregu.00277.2009",

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T1 - Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males

AU - Seifert, T

AU - Rasmussen, P

AU - Brassard, P

AU - Homann, P H

AU - Wissenberg, M

AU - Nordby, P

AU - Stallknecht, B

AU - Secher, N H

AU - Nielsen, H B

N1 - Keywords: Adaptation, Physiological; Adult; Blood Glucose; Brain; Cerebrovascular Circulation; Epinephrine; Exercise; Exercise Tolerance; Hemodynamics; Humans; Lactic Acid; Male; Mitochondria; Norepinephrine; Overweight; Oxygen; Oxygen Consumption; Physical Endurance; Time Factors; Ultrasonography, Doppler, Transcranial

PY - 2009

Y1 - 2009

N2 - Endurance training improves muscular and cardiovascular fitness, but the effect on cerebral oxygenation and metabolism remains unknown. We hypothesized that 3 mo of endurance training would reduce cerebral carbohydrate uptake with maintained cerebral oxygenation during submaximal exercise. Healthy overweight males were included in a randomized, controlled study (training: n = 10; control: n = 7). Arterial and internal jugular venous catheterization was used to determine concentration differences for oxygen, glucose, and lactate across the brain and the oxygen-carbohydrate index [molar uptake of oxygen/(glucose + (1/2) lactate); OCI], changes in mitochondrial oxygen tension (DeltaP(Mito)O(2)) and the cerebral metabolic rate of oxygen (CMRO(2)) were calculated. For all subjects, resting OCI was higher at the 3-mo follow-up (6.3 +/- 1.3 compared with 4.7 +/- 0.9 at baseline, mean +/- SD; P < 0.05) and coincided with a lower plasma epinephrine concentration (P < 0.05). Cerebral adaptations to endurance training manifested when exercising at 70% of maximal oxygen uptake (approximately 211 W). Before training, both OCI (3.9 +/- 0.9) and DeltaP(Mito)O(2) (-22 mmHg) decreased (P < 0.05), whereas CMRO(2) increased by 79 +/- 53 micromol x 100 x g(-1) min(-1) (P < 0.05). At the 3-mo follow-up, OCI (4.9 +/- 1.0) and DeltaP(Mito)O(2) (-7 +/- 13 mmHg) did not decrease significantly from rest and when compared with values before training (P < 0.05), CMRO(2) did not increase. This study demonstrates that endurance training attenuates the cerebral metabolic response to submaximal exercise, as reflected in a lower carbohydrate uptake and maintained cerebral oxygenation.

AB - Endurance training improves muscular and cardiovascular fitness, but the effect on cerebral oxygenation and metabolism remains unknown. We hypothesized that 3 mo of endurance training would reduce cerebral carbohydrate uptake with maintained cerebral oxygenation during submaximal exercise. Healthy overweight males were included in a randomized, controlled study (training: n = 10; control: n = 7). Arterial and internal jugular venous catheterization was used to determine concentration differences for oxygen, glucose, and lactate across the brain and the oxygen-carbohydrate index [molar uptake of oxygen/(glucose + (1/2) lactate); OCI], changes in mitochondrial oxygen tension (DeltaP(Mito)O(2)) and the cerebral metabolic rate of oxygen (CMRO(2)) were calculated. For all subjects, resting OCI was higher at the 3-mo follow-up (6.3 +/- 1.3 compared with 4.7 +/- 0.9 at baseline, mean +/- SD; P < 0.05) and coincided with a lower plasma epinephrine concentration (P < 0.05). Cerebral adaptations to endurance training manifested when exercising at 70% of maximal oxygen uptake (approximately 211 W). Before training, both OCI (3.9 +/- 0.9) and DeltaP(Mito)O(2) (-22 mmHg) decreased (P < 0.05), whereas CMRO(2) increased by 79 +/- 53 micromol x 100 x g(-1) min(-1) (P < 0.05). At the 3-mo follow-up, OCI (4.9 +/- 1.0) and DeltaP(Mito)O(2) (-7 +/- 13 mmHg) did not decrease significantly from rest and when compared with values before training (P < 0.05), CMRO(2) did not increase. This study demonstrates that endurance training attenuates the cerebral metabolic response to submaximal exercise, as reflected in a lower carbohydrate uptake and maintained cerebral oxygenation.

U2 - 10.1152/ajpregu.00277.2009

DO - 10.1152/ajpregu.00277.2009

M3 - Journal article

C2 - 19605762

SN - 0363-6119

VL - 297

SP - R867-76

JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

IS - 3

ER -

Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males

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