Cerebral formation of free radicals during hypoxia does not cause structural damage and is associated with a reduction in mitochondrial PO2; evidence of O2-sensing in humans?

Damian M Bailey; Sarah Taudorf; Ronan M G Berg; Carsten Lundby; Bente K Pedersen; Peter Rasmussen; Kirsten Møller

doi:http://dx.doi.org/10.1038/jcbfm.2011.2

Cerebral formation of free radicals during hypoxia does not cause structural damage and is associated with a reduction in mitochondrial PO2; evidence of O2-sensing in humans?

Damian M Bailey, Sarah Taudorf, Ronan M G Berg, Carsten Lundby, Bente K Pedersen, Peter Rasmussen, Kirsten Møller

20 Citations (Scopus)

Abstract

Cellular hypoxia triggers a homeostatic increase in mitochondrial free radical signaling. In this study, blood was obtained from the radial artery and jugular venous bulb in 10 men during normoxia and 9 hours hypoxia (12.9% O ₂). Mitochondrial oxygen tension (P^-mitO₂) was derived from cerebral blood flow and blood gases. The ascorbate radical (A ^•-) was detected by electron paramagnetic resonance spectroscopy and neuron-specific enolase (NSE), a biomarker of neuronal injury, by enzyme-linked immunosorbent assay. Hypoxia increased the cerebral output of A in proportion to the reduction in P^-mitO₂, but did not affect NSE exchange. These findings suggest that neuro-oxidative stress may constitute an adaptive response.

Original language	English
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	31
Issue number	4
Pages (from-to)	1020-6
Number of pages	7
ISSN	0271-678X
DOIs	https://doi.org/10.1038/jcbfm.2011.2
Publication status	Published - Apr 2011

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http://dx.doi.org/10.1038/jcbfm.2011.2

Cite this

Bailey, D. M., Taudorf, S., Berg, R. M. G., Lundby, C., Pedersen, B. K., Rasmussen, P., & Møller, K. (2011). Cerebral formation of free radicals during hypoxia does not cause structural damage and is associated with a reduction in mitochondrial PO2; evidence of O2-sensing in humans? Journal of Cerebral Blood Flow and Metabolism, 31(4), 1020-6. https://doi.org/10.1038/jcbfm.2011.2

Cerebral formation of free radicals during hypoxia does not cause structural damage and is associated with a reduction in mitochondrial PO2; evidence of O2-sensing in humans? / Bailey, Damian M; Taudorf, Sarah; Berg, Ronan M G et al.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 31, No. 4, 04.2011, p. 1020-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Bailey, DM, Taudorf, S, Berg, RMG, Lundby, C, Pedersen, BK, Rasmussen, P & Møller, K 2011, 'Cerebral formation of free radicals during hypoxia does not cause structural damage and is associated with a reduction in mitochondrial PO2; evidence of O2-sensing in humans?', Journal of Cerebral Blood Flow and Metabolism, vol. 31, no. 4, pp. 1020-6. https://doi.org/10.1038/jcbfm.2011.2

@article{946feb7c0d3e42e58422a0594ec211a0,

title = "Cerebral formation of free radicals during hypoxia does not cause structural damage and is associated with a reduction in mitochondrial PO2; evidence of O2-sensing in humans?",

abstract = "Cellular hypoxia triggers a homeostatic increase in mitochondrial free radical signaling. In this study, blood was obtained from the radial artery and jugular venous bulb in 10 men during normoxia and 9 hours hypoxia (12.9% O 2). Mitochondrial oxygen tension (P-mitO2) was derived from cerebral blood flow and blood gases. The ascorbate radical (A •-) was detected by electron paramagnetic resonance spectroscopy and neuron-specific enolase (NSE), a biomarker of neuronal injury, by enzyme-linked immunosorbent assay. Hypoxia increased the cerebral output of A in proportion to the reduction in P-mitO2, but did not affect NSE exchange. These findings suggest that neuro-oxidative stress may constitute an adaptive response.",

author = "Bailey, {Damian M} and Sarah Taudorf and Berg, {Ronan M G} and Carsten Lundby and Pedersen, {Bente K} and Peter Rasmussen and Kirsten M{\o}ller",

year = "2011",

month = apr,

doi = "http://dx.doi.org/10.1038/jcbfm.2011.2",

language = "English",

volume = "31",

pages = "1020--6",

journal = "Journal of Cerebral Blood Flow and Metabolism",

issn = "0271-678X",