Central and noncentral blood volumes in cirrhosis: relationship to anthropometrics and gender

Søren Møller; Jens H Henriksen; Flemming Bendtsen

doi:10.1152/ajpgi.00521.2002

Central and noncentral blood volumes in cirrhosis: relationship to anthropometrics and gender

Søren Møller, Jens H Henriksen, Flemming Bendtsen

55 Citations (Scopus)

Abstract

The size of the central and arterial blood volume (CBV) is essential in the understanding of fluid retention in cirrhosis. Previously, it has been reported decreased, normal, or increased, but no reports have analyzed CBV with respect to gender and lean body mass. The aim of the present study was by means of an optimized technique to reassess it in a large group of patients with cirrhosis compared with healthy controls and matched controls in relationship to their body dimensions and gender. Eighty-three patients with cirrhosis (male/female, 60:23), 67 patients without liver disease (male/female, 22:45), and 14 young healthy controls (male/female, 6:8) underwent a hemodynamic investigation with determination of cardiac output, central circulation time, and CBV determined according to kinetic principles. Related to gender, CBV was lower in male cirrhotics (1.48 +/- 0.30 liter) than in matched and young controls (1.68 +/- 0.33 and 1.72 +/- 0.33 liter, respectively; P < 0.05-0.01). No significant differences in CBV were seen between female cirrhotics and controls. Absolute and adjusted CBVs were lower in the females than in men with cirrhosis (P < 0.001), and men with cirrhosis had lower absolute and body weight-adjusted CBVs than matched controls (P < 0.01). Normalized values of CBV (%total blood volume) were significantly lower in patients with cirrhosis (25 +/- 4%) than in matched controls (31 +/- 7%) and young controls (28 +/- 4%; P < 0.02). CBV correlated significantly with anthropometrics, including lean body mass (r = 0.68-0.82; P < 0.0001). In conclusion, the CBV of patients with cirrhosis was lower than that of controls when adjusted for body dimensions and gender. There are significant gender differences, and signs of underfilling are more pronounced in male than in female patients. The results emphasize the importance of adjustments of blood volumes for anthropometrics and gender.

Original language	English
Journal	American Journal of Physiology: Gastrointestinal and Liver Physiology
Volume	284
Issue number	6
Pages (from-to)	G970-9
ISSN	0193-1857
DOIs	https://doi.org/10.1152/ajpgi.00521.2002
Publication status	Published - 2003

Access to Document

10.1152/ajpgi.00521.2002

Cite this

@article{9263a1001d5611df8ed1000ea68e967b,

title = "Central and noncentral blood volumes in cirrhosis: relationship to anthropometrics and gender",

abstract = "The size of the central and arterial blood volume (CBV) is essential in the understanding of fluid retention in cirrhosis. Previously, it has been reported decreased, normal, or increased, but no reports have analyzed CBV with respect to gender and lean body mass. The aim of the present study was by means of an optimized technique to reassess it in a large group of patients with cirrhosis compared with healthy controls and matched controls in relationship to their body dimensions and gender. Eighty-three patients with cirrhosis (male/female, 60:23), 67 patients without liver disease (male/female, 22:45), and 14 young healthy controls (male/female, 6:8) underwent a hemodynamic investigation with determination of cardiac output, central circulation time, and CBV determined according to kinetic principles. Related to gender, CBV was lower in male cirrhotics (1.48 +/- 0.30 liter) than in matched and young controls (1.68 +/- 0.33 and 1.72 +/- 0.33 liter, respectively; P < 0.05-0.01). No significant differences in CBV were seen between female cirrhotics and controls. Absolute and adjusted CBVs were lower in the females than in men with cirrhosis (P < 0.001), and men with cirrhosis had lower absolute and body weight-adjusted CBVs than matched controls (P < 0.01). Normalized values of CBV (%total blood volume) were significantly lower in patients with cirrhosis (25 +/- 4%) than in matched controls (31 +/- 7%) and young controls (28 +/- 4%; P < 0.02). CBV correlated significantly with anthropometrics, including lean body mass (r = 0.68-0.82; P < 0.0001). In conclusion, the CBV of patients with cirrhosis was lower than that of controls when adjusted for body dimensions and gender. There are significant gender differences, and signs of underfilling are more pronounced in male than in female patients. The results emphasize the importance of adjustments of blood volumes for anthropometrics and gender.",

author = "S{\o}ren M{\o}ller and Henriksen, {Jens H} and Flemming Bendtsen",

note = "Keywords: Adult; Aged; Aged, 80 and over; Anthropometry; Blood Circulation; Blood Volume; Body Constitution; Female; Hemodynamics; Humans; Liver Cirrhosis; Male; Middle Aged; Sex Characteristics",

year = "2003",

doi = "10.1152/ajpgi.00521.2002",

language = "English",

volume = "284",

pages = "G970--9",

journal = "American Journal of Physiology: Gastrointestinal and Liver Physiology",

issn = "0193-1857",

publisher = "American Physiological Society",

number = "6",

}

TY - JOUR

T1 - Central and noncentral blood volumes in cirrhosis: relationship to anthropometrics and gender

AU - Møller, Søren

AU - Henriksen, Jens H

AU - Bendtsen, Flemming

N1 - Keywords: Adult; Aged; Aged, 80 and over; Anthropometry; Blood Circulation; Blood Volume; Body Constitution; Female; Hemodynamics; Humans; Liver Cirrhosis; Male; Middle Aged; Sex Characteristics

PY - 2003

Y1 - 2003

N2 - The size of the central and arterial blood volume (CBV) is essential in the understanding of fluid retention in cirrhosis. Previously, it has been reported decreased, normal, or increased, but no reports have analyzed CBV with respect to gender and lean body mass. The aim of the present study was by means of an optimized technique to reassess it in a large group of patients with cirrhosis compared with healthy controls and matched controls in relationship to their body dimensions and gender. Eighty-three patients with cirrhosis (male/female, 60:23), 67 patients without liver disease (male/female, 22:45), and 14 young healthy controls (male/female, 6:8) underwent a hemodynamic investigation with determination of cardiac output, central circulation time, and CBV determined according to kinetic principles. Related to gender, CBV was lower in male cirrhotics (1.48 +/- 0.30 liter) than in matched and young controls (1.68 +/- 0.33 and 1.72 +/- 0.33 liter, respectively; P < 0.05-0.01). No significant differences in CBV were seen between female cirrhotics and controls. Absolute and adjusted CBVs were lower in the females than in men with cirrhosis (P < 0.001), and men with cirrhosis had lower absolute and body weight-adjusted CBVs than matched controls (P < 0.01). Normalized values of CBV (%total blood volume) were significantly lower in patients with cirrhosis (25 +/- 4%) than in matched controls (31 +/- 7%) and young controls (28 +/- 4%; P < 0.02). CBV correlated significantly with anthropometrics, including lean body mass (r = 0.68-0.82; P < 0.0001). In conclusion, the CBV of patients with cirrhosis was lower than that of controls when adjusted for body dimensions and gender. There are significant gender differences, and signs of underfilling are more pronounced in male than in female patients. The results emphasize the importance of adjustments of blood volumes for anthropometrics and gender.

AB - The size of the central and arterial blood volume (CBV) is essential in the understanding of fluid retention in cirrhosis. Previously, it has been reported decreased, normal, or increased, but no reports have analyzed CBV with respect to gender and lean body mass. The aim of the present study was by means of an optimized technique to reassess it in a large group of patients with cirrhosis compared with healthy controls and matched controls in relationship to their body dimensions and gender. Eighty-three patients with cirrhosis (male/female, 60:23), 67 patients without liver disease (male/female, 22:45), and 14 young healthy controls (male/female, 6:8) underwent a hemodynamic investigation with determination of cardiac output, central circulation time, and CBV determined according to kinetic principles. Related to gender, CBV was lower in male cirrhotics (1.48 +/- 0.30 liter) than in matched and young controls (1.68 +/- 0.33 and 1.72 +/- 0.33 liter, respectively; P < 0.05-0.01). No significant differences in CBV were seen between female cirrhotics and controls. Absolute and adjusted CBVs were lower in the females than in men with cirrhosis (P < 0.001), and men with cirrhosis had lower absolute and body weight-adjusted CBVs than matched controls (P < 0.01). Normalized values of CBV (%total blood volume) were significantly lower in patients with cirrhosis (25 +/- 4%) than in matched controls (31 +/- 7%) and young controls (28 +/- 4%; P < 0.02). CBV correlated significantly with anthropometrics, including lean body mass (r = 0.68-0.82; P < 0.0001). In conclusion, the CBV of patients with cirrhosis was lower than that of controls when adjusted for body dimensions and gender. There are significant gender differences, and signs of underfilling are more pronounced in male than in female patients. The results emphasize the importance of adjustments of blood volumes for anthropometrics and gender.

U2 - 10.1152/ajpgi.00521.2002

DO - 10.1152/ajpgi.00521.2002

M3 - Journal article

C2 - 12606306

SN - 0193-1857

VL - 284

SP - G970-9

JO - American Journal of Physiology: Gastrointestinal and Liver Physiology

JF - American Journal of Physiology: Gastrointestinal and Liver Physiology

IS - 6

ER -

Central and noncentral blood volumes in cirrhosis: relationship to anthropometrics and gender

Abstract

Access to Document

Fingerprint

Cite this