Cellular mechanisms that control mistranslation

Noah M Reynolds; Beth A Lazazzera; Michael Ibba

doi:10.1038/nrmicro2472

Cellular mechanisms that control mistranslation

Noah M Reynolds, Beth A Lazazzera, Michael Ibba

Transcription, RNA, and Gene Medicine Program

103 Citations (Scopus)

Abstract

Mistranslation broadly encompasses the introduction of errors during any step of protein synthesis, leading to the incorporation of an amino acid that is different from the one encoded by the gene. Recent research has vastly enhanced our understanding of the mechanisms that control mistranslation at the molecular level and has led to the discovery that the rates of mistranslation in vivo are not fixed but instead are variable. In this Review we describe the different steps in translation quality control and their variations under different growth conditions and between species though a comparison of in vitro and in vivo findings. This provides new insights as to why mistranslation can have both positive and negative effects on growth and viability.

Original language	English
Journal	Nature Reviews. Microbiology
Volume	8
Issue number	12
Pages (from-to)	849-56
Number of pages	8
ISSN	1740-1526
DOIs	https://doi.org/10.1038/nrmicro2472
Publication status	Published - 1 Dec 2010

Keywords

Amino Acids
Animals
Cell Physiological Phenomena
Humans
Protein Biosynthesis
Protein Folding
RNA, Transfer

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10.1038/nrmicro2472

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abstract = "Mistranslation broadly encompasses the introduction of errors during any step of protein synthesis, leading to the incorporation of an amino acid that is different from the one encoded by the gene. Recent research has vastly enhanced our understanding of the mechanisms that control mistranslation at the molecular level and has led to the discovery that the rates of mistranslation in vivo are not fixed but instead are variable. In this Review we describe the different steps in translation quality control and their variations under different growth conditions and between species though a comparison of in vitro and in vivo findings. This provides new insights as to why mistranslation can have both positive and negative effects on growth and viability.",

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AU - Lazazzera, Beth A

AU - Ibba, Michael

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N2 - Mistranslation broadly encompasses the introduction of errors during any step of protein synthesis, leading to the incorporation of an amino acid that is different from the one encoded by the gene. Recent research has vastly enhanced our understanding of the mechanisms that control mistranslation at the molecular level and has led to the discovery that the rates of mistranslation in vivo are not fixed but instead are variable. In this Review we describe the different steps in translation quality control and their variations under different growth conditions and between species though a comparison of in vitro and in vivo findings. This provides new insights as to why mistranslation can have both positive and negative effects on growth and viability.

AB - Mistranslation broadly encompasses the introduction of errors during any step of protein synthesis, leading to the incorporation of an amino acid that is different from the one encoded by the gene. Recent research has vastly enhanced our understanding of the mechanisms that control mistranslation at the molecular level and has led to the discovery that the rates of mistranslation in vivo are not fixed but instead are variable. In this Review we describe the different steps in translation quality control and their variations under different growth conditions and between species though a comparison of in vitro and in vivo findings. This provides new insights as to why mistranslation can have both positive and negative effects on growth and viability.

KW - Amino Acids

KW - Animals

KW - Cell Physiological Phenomena

KW - Humans

KW - Protein Biosynthesis

KW - Protein Folding

KW - RNA, Transfer

U2 - 10.1038/nrmicro2472

DO - 10.1038/nrmicro2472

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VL - 8

SP - 849

EP - 856

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 12

ER -

Cellular mechanisms that control mistranslation

Abstract

Keywords

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