CD4 T cell activation and disease activity at onset of multiple sclerosis.

TY - JOUR

T1 - CD4 T cell activation and disease activity at onset of multiple sclerosis.

AU - Jensen, J

AU - Langkilde, Annika Reynberg

AU - Fenst, C

AU - Nicolaisen, M. S.

AU - Roed, H. G.

AU - Christensen, M

AU - Sellebjerg, F

PY - 2004

Y1 - 2004

N2 - We studied CD4 T cell activation in patients with clinically isolated syndromes (CIS) suggesting an initial attack of multiple sclerosis. The percentage of blood CD26+ CD4 T cells was increased in these patients, and correlated with magnetic resonance imaging disease activity and clinical disease severity. In contrast, the percentage of CD25+ CD4 T cells in cerebrospinal fluid correlated negatively with the cerebrospinal fluid concentration of myelin basic protein and the presence of IgG oligoclonal bands. These results suggest that distinct systemic and intrathecal T cell activation states correlate with disease activity and risk of subsequently developing MS in CIS patients

AB - We studied CD4 T cell activation in patients with clinically isolated syndromes (CIS) suggesting an initial attack of multiple sclerosis. The percentage of blood CD26+ CD4 T cells was increased in these patients, and correlated with magnetic resonance imaging disease activity and clinical disease severity. In contrast, the percentage of CD25+ CD4 T cells in cerebrospinal fluid correlated negatively with the cerebrospinal fluid concentration of myelin basic protein and the presence of IgG oligoclonal bands. These results suggest that distinct systemic and intrathecal T cell activation states correlate with disease activity and risk of subsequently developing MS in CIS patients

M3 - Journal article

SN - 0165-5728

VL - 149

SP - 202

EP - 209

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -