CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection

Aase B. Andersen; Nyagosya Range; John Changalucha; George PrayGod; Jeremiah Kidola; Daniel Faurholt-Jepsen; Henrik Bygum Krarup; Harleen M.S. Grewal; Henrik Friis

doi:10.1186/1471-2334-12-66

CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection

Aase B. Andersen, Nyagosya Range, John Changalucha, George PrayGod, Jeremiah Kidola, Daniel Faurholt-Jepsen, Henrik Bygum Krarup, Harleen M.S. Grewal, Henrik Friis

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Abstract

Background: The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported.Methods: CD4 counts were assessed from time of diagnosis till the end of TB treatment in a cohort of pulmonary TB patients with and without HIV co-infection and compared with cross-sectional data on age- and sex-matched non-TB controls from the same area.Results: Of 1,605 study participants, 1,250 were PTB patients and 355 were non-TB controls. At baseline, HIV was associated with 246 (95% CI: 203; 279) cells per μL lower CD4 counts. All PTB patients had 100 cells per μL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and those already on ART at baseline had no increase in CD4 counts after 5 months of TB treatment, whereas those prescribed ART between baseline and 2 months, and between 2 and 5 months increased by 69 (22;117) and 110 (52; 168) CD4 cells per μL after 5 months.Conclusions: The increase in circulating CD4 levels observed in PTB in patients is acquired after 2 months of treatment irrespective of HIV status. Initiation of ART is the strongest factor correlated with CD4 increase during TB treatment.Trial registration number: Clinical trials.gov: NCT00311298.

Original language	English
Journal	B M C Infectious Diseases
Volume	12
Issue number	66
Pages (from-to)	1-7
Number of pages	7
ISSN	1471-2334
DOIs	https://doi.org/10.1186/1471-2334-12-66
Publication status	Published - 21 Mar 2012

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title = "CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection",

abstract = "Background: The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported.Methods: CD4 counts were assessed from time of diagnosis till the end of TB treatment in a cohort of pulmonary TB patients with and without HIV co-infection and compared with cross-sectional data on age- and sex-matched non-TB controls from the same area.Results: Of 1,605 study participants, 1,250 were PTB patients and 355 were non-TB controls. At baseline, HIV was associated with 246 (95% CI: 203; 279) cells per μL lower CD4 counts. All PTB patients had 100 cells per μL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and those already on ART at baseline had no increase in CD4 counts after 5 months of TB treatment, whereas those prescribed ART between baseline and 2 months, and between 2 and 5 months increased by 69 (22;117) and 110 (52; 168) CD4 cells per μL after 5 months.Conclusions: The increase in circulating CD4 levels observed in PTB in patients is acquired after 2 months of treatment irrespective of HIV status. Initiation of ART is the strongest factor correlated with CD4 increase during TB treatment.Trial registration number: Clinical trials.gov: NCT00311298.",

author = "Andersen, {Aase B.} and Nyagosya Range and John Changalucha and George PrayGod and Jeremiah Kidola and Daniel Faurholt-Jepsen and Krarup, {Henrik Bygum} and Grewal, {Harleen M.S.} and Henrik Friis",

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T1 - CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection

AU - Andersen, Aase B.

AU - Range, Nyagosya

AU - Changalucha, John

AU - PrayGod, George

AU - Kidola, Jeremiah

AU - Faurholt-Jepsen, Daniel

AU - Krarup, Henrik Bygum

AU - Grewal, Harleen M.S.

AU - Friis, Henrik

PY - 2012/3/21

Y1 - 2012/3/21

N2 - Background: The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported.Methods: CD4 counts were assessed from time of diagnosis till the end of TB treatment in a cohort of pulmonary TB patients with and without HIV co-infection and compared with cross-sectional data on age- and sex-matched non-TB controls from the same area.Results: Of 1,605 study participants, 1,250 were PTB patients and 355 were non-TB controls. At baseline, HIV was associated with 246 (95% CI: 203; 279) cells per μL lower CD4 counts. All PTB patients had 100 cells per μL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and those already on ART at baseline had no increase in CD4 counts after 5 months of TB treatment, whereas those prescribed ART between baseline and 2 months, and between 2 and 5 months increased by 69 (22;117) and 110 (52; 168) CD4 cells per μL after 5 months.Conclusions: The increase in circulating CD4 levels observed in PTB in patients is acquired after 2 months of treatment irrespective of HIV status. Initiation of ART is the strongest factor correlated with CD4 increase during TB treatment.Trial registration number: Clinical trials.gov: NCT00311298.

AB - Background: The interaction of HIV and tuberculosis (TB) on CD4 levels over time is complex and has been divergently reported.Methods: CD4 counts were assessed from time of diagnosis till the end of TB treatment in a cohort of pulmonary TB patients with and without HIV co-infection and compared with cross-sectional data on age- and sex-matched non-TB controls from the same area.Results: Of 1,605 study participants, 1,250 were PTB patients and 355 were non-TB controls. At baseline, HIV was associated with 246 (95% CI: 203; 279) cells per μL lower CD4 counts. All PTB patients had 100 cells per μL lower CD4 counts than the healthy controls. The CD4 levels were largely unchanged during a five-month of TB treatment. HIV infected patients not receiving ART at any time and those already on ART at baseline had no increase in CD4 counts after 5 months of TB treatment, whereas those prescribed ART between baseline and 2 months, and between 2 and 5 months increased by 69 (22;117) and 110 (52; 168) CD4 cells per μL after 5 months.Conclusions: The increase in circulating CD4 levels observed in PTB in patients is acquired after 2 months of treatment irrespective of HIV status. Initiation of ART is the strongest factor correlated with CD4 increase during TB treatment.Trial registration number: Clinical trials.gov: NCT00311298.

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DO - 10.1186/1471-2334-12-66

M3 - Journal article

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EP - 7

JO - B M C Infectious Diseases

JF - B M C Infectious Diseases

IS - 66

ER -

CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection

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