Cavity-enhanced optical frequency combspectroscopy: Application to human breathanalysis

David Morten Balslev-Clausen; M. J. Thorpe; M. S. Kirchner; J. Ye

doi:10.1364/OE.16.002387

Cavity-enhanced optical frequency combspectroscopy: Application to human breathanalysis

David Morten Balslev-Clausen, M. J. Thorpe, M. S. Kirchner, J. Ye

Physics of Ice, Climate and Earth

252 Citations (Scopus)

Abstract

Broad-bandwidth, high-spectral-resolution optical detection of human breath has identified multiple important biomarkers correlated with specific diseases and metabolic processes. This optical-frequency-comb-based breath analysis system comes with excellent performance in all criteria: high detection sensitivity, ability to identify and distinguish a large number of analytes, and simultaneous, real-time information processing. We demonstrate a minimum detectable absorption of 8 x 10^-10cm^-1, a spectral resolution of 800 MHz, and 200 nm of spectral coverage from 1.5 to 1.7 µm where strong and unique molecular fingerprints exist for many biomarkers. We present a series of breath measurements including stable isotope ratios of CO₂, breath concentrations of CO, and the presence of trace concentrations of NH₃ in high concentrations of H₂O.
Udgivelsesdato: 02.05

Original language	English
Journal	Optics Express
Volume	16
Issue number	4
Pages (from-to)	2387-2397
Number of pages	10
ISSN	1094-4087
DOIs	https://doi.org/10.1364/OE.16.002387
Publication status	Published - 2008

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10.1364/OE.16.002387

Cite this

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title = "Cavity-enhanced optical frequency combspectroscopy: Application to human breathanalysis",

abstract = "Broad-bandwidth, high-spectral-resolution optical detection of human breath has identified multiple important biomarkers correlated with specific diseases and metabolic processes. This optical-frequency-comb-based breath analysis system comes with excellent performance in all criteria: high detection sensitivity, ability to identify and distinguish a large number of analytes, and simultaneous, real-time information processing. We demonstrate a minimum detectable absorption of 8 x 10-10cm-1, a spectral resolution of 800 MHz, and 200 nm of spectral coverage from 1.5 to 1.7 µm where strong and unique molecular fingerprints exist for many biomarkers. We present a series of breath measurements including stable isotope ratios of CO2, breath concentrations of CO, and the presence of trace concentrations of NH3 in high concentrations of H2O. Udgivelsesdato: 02.05",

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T2 - Application to human breathanalysis

AU - Balslev-Clausen, David Morten

AU - Thorpe, M. J.

AU - Kirchner, M. S.

AU - Ye, J.

PY - 2008

Y1 - 2008

N2 - Broad-bandwidth, high-spectral-resolution optical detection of human breath has identified multiple important biomarkers correlated with specific diseases and metabolic processes. This optical-frequency-comb-based breath analysis system comes with excellent performance in all criteria: high detection sensitivity, ability to identify and distinguish a large number of analytes, and simultaneous, real-time information processing. We demonstrate a minimum detectable absorption of 8 x 10-10cm-1, a spectral resolution of 800 MHz, and 200 nm of spectral coverage from 1.5 to 1.7 µm where strong and unique molecular fingerprints exist for many biomarkers. We present a series of breath measurements including stable isotope ratios of CO2, breath concentrations of CO, and the presence of trace concentrations of NH3 in high concentrations of H2O. Udgivelsesdato: 02.05

AB - Broad-bandwidth, high-spectral-resolution optical detection of human breath has identified multiple important biomarkers correlated with specific diseases and metabolic processes. This optical-frequency-comb-based breath analysis system comes with excellent performance in all criteria: high detection sensitivity, ability to identify and distinguish a large number of analytes, and simultaneous, real-time information processing. We demonstrate a minimum detectable absorption of 8 x 10-10cm-1, a spectral resolution of 800 MHz, and 200 nm of spectral coverage from 1.5 to 1.7 µm where strong and unique molecular fingerprints exist for many biomarkers. We present a series of breath measurements including stable isotope ratios of CO2, breath concentrations of CO, and the presence of trace concentrations of NH3 in high concentrations of H2O. Udgivelsesdato: 02.05

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DO - 10.1364/OE.16.002387

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