Causes of Hospital Admissions in Domus: A Randomized Controlled Trial of Specialized Palliative Cancer Care at Home

Kirstine Skov Benthien; Mie Nordly; Annika von Heymann-Horan; Kristina Rosengaard Holmenlund; Helle Timm; Geana Paula Kurita; Christoffer Johansen; Jakob Kjellberg; Hans von der Maase; Per Sjøgren

doi:10.1016/j.jpainsymman.2017.10.007

Causes of Hospital Admissions in Domus: A Randomized Controlled Trial of Specialized Palliative Cancer Care at Home

Kirstine Skov Benthien, Mie Nordly, Annika von Heymann-Horan, Kristina Rosengaard Holmenlund, Helle Timm, Geana Paula Kurita, Christoffer Johansen, Jakob Kjellberg, Hans von der Maase, Per Sjøgren

Department of Clinical Medicine

5 Citations (Scopus)

Abstract

CONTEXT: Avoidable hospital admissions are important negative indicators of quality of end-of-life care. Specialized palliative care (SPC) may support patients remaining at home.

OBJECTIVES: Therefore, the purpose of this study was to investigate if SPC at home could prevent hospital admissions in patients with incurable cancer.

METHODS: These are secondary results of Domus: a randomized controlled trial of accelerated transition to SPC with psychological intervention at home (Clinicaltrials.gov: NCT01885637). Participants were patients with incurable cancer and limited antineoplastic treatment options and their caregivers. They were included from the Department of Oncology, Rigshospitalet, Denmark, between 2013 and 2016. The control group received usual care. Outcomes were hospital admissions, causes thereof, and patient and caregiver perceptions of place of care (home, hospital, etc.) at baseline, four weeks, eight weeks, and six months.

RESULTS: During the study, 340 patients were randomized and 322 were included in modified intention-to-treat analyses. Overall, there were no significant differences in hospital admissions between the groups. The intervention group had more admissions triggered by worsened general health (22% vs. 16%, P = 0.0436) or unmanageable home situation (8% vs. 4%, P = 0.0119). After diagnostics, admissions were more often caused by clinical symptoms of cancer without progression in the intervention group (11% vs. 7%, P = 0.0493). The two groups did not differ significantly in overall potentially avoidable admissions. Both groups felt mostly safe about their place of care.

CONCLUSION: The intervention did not prevent hospital admissions. Likely, any intervention effects were outweighed by increased identification of problems in the intervention group leading to hospital admissions. Overall, patients and caregivers felt safe in their current place of care.

Original language	English
Journal	Journal of Pain and Symptom Management
Volume	55
Issue number	3
Pages (from-to)	728-736
ISSN	0885-3924
DOIs	https://doi.org/10.1016/j.jpainsymman.2017.10.007
Publication status	Published - Mar 2018

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10.1016/j.jpainsymman.2017.10.007

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Skov Benthien, K., Nordly, M., von Heymann-Horan, A., Rosengaard Holmenlund, K., Timm, H., Kurita, G. P., Johansen, C., Kjellberg, J., von der Maase, H., & Sjøgren, P. (2018). Causes of Hospital Admissions in Domus: A Randomized Controlled Trial of Specialized Palliative Cancer Care at Home. Journal of Pain and Symptom Management, 55(3), 728-736. https://doi.org/10.1016/j.jpainsymman.2017.10.007

Skov Benthien, K, Nordly, M, von Heymann-Horan, A, Rosengaard Holmenlund, K, Timm, H, Kurita, GP, Johansen, C, Kjellberg, J, von der Maase, H & Sjøgren, P 2018, 'Causes of Hospital Admissions in Domus: A Randomized Controlled Trial of Specialized Palliative Cancer Care at Home', Journal of Pain and Symptom Management, vol. 55, no. 3, pp. 728-736. https://doi.org/10.1016/j.jpainsymman.2017.10.007

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title = "Causes of Hospital Admissions in Domus: A Randomized Controlled Trial of Specialized Palliative Cancer Care at Home",

abstract = "CONTEXT: Avoidable hospital admissions are important negative indicators of quality of end-of-life care. Specialized palliative care (SPC) may support patients remaining at home.OBJECTIVES: Therefore, the purpose of this study was to investigate if SPC at home could prevent hospital admissions in patients with incurable cancer.METHODS: These are secondary results of Domus: a randomized controlled trial of accelerated transition to SPC with psychological intervention at home (Clinicaltrials.gov: NCT01885637). Participants were patients with incurable cancer and limited antineoplastic treatment options and their caregivers. They were included from the Department of Oncology, Rigshospitalet, Denmark, between 2013 and 2016. The control group received usual care. Outcomes were hospital admissions, causes thereof, and patient and caregiver perceptions of place of care (home, hospital, etc.) at baseline, four weeks, eight weeks, and six months.RESULTS: During the study, 340 patients were randomized and 322 were included in modified intention-to-treat analyses. Overall, there were no significant differences in hospital admissions between the groups. The intervention group had more admissions triggered by worsened general health (22% vs. 16%, P = 0.0436) or unmanageable home situation (8% vs. 4%, P = 0.0119). After diagnostics, admissions were more often caused by clinical symptoms of cancer without progression in the intervention group (11% vs. 7%, P = 0.0493). The two groups did not differ significantly in overall potentially avoidable admissions. Both groups felt mostly safe about their place of care.CONCLUSION: The intervention did not prevent hospital admissions. Likely, any intervention effects were outweighed by increased identification of problems in the intervention group leading to hospital admissions. Overall, patients and caregivers felt safe in their current place of care.",

author = "{Skov Benthien}, Kirstine and Mie Nordly and {von Heymann-Horan}, Annika and {Rosengaard Holmenlund}, Kristina and Helle Timm and Kurita, {Geana Paula} and Christoffer Johansen and Jakob Kjellberg and {von der Maase}, Hans and Per Sj{\o}gren",

year = "2018",

month = mar,

doi = "10.1016/j.jpainsymman.2017.10.007",

language = "English",

volume = "55",

pages = "728--736",

journal = "Journal of Pain and Symptom Management",

issn = "0885-3924",

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TY - JOUR

T1 - Causes of Hospital Admissions in Domus

T2 - A Randomized Controlled Trial of Specialized Palliative Cancer Care at Home

AU - Skov Benthien, Kirstine

AU - Nordly, Mie

AU - von Heymann-Horan, Annika

AU - Rosengaard Holmenlund, Kristina

AU - Timm, Helle

AU - Kurita, Geana Paula

AU - Johansen, Christoffer

AU - Kjellberg, Jakob

AU - von der Maase, Hans

AU - Sjøgren, Per

PY - 2018/3

Y1 - 2018/3

N2 - CONTEXT: Avoidable hospital admissions are important negative indicators of quality of end-of-life care. Specialized palliative care (SPC) may support patients remaining at home.OBJECTIVES: Therefore, the purpose of this study was to investigate if SPC at home could prevent hospital admissions in patients with incurable cancer.METHODS: These are secondary results of Domus: a randomized controlled trial of accelerated transition to SPC with psychological intervention at home (Clinicaltrials.gov: NCT01885637). Participants were patients with incurable cancer and limited antineoplastic treatment options and their caregivers. They were included from the Department of Oncology, Rigshospitalet, Denmark, between 2013 and 2016. The control group received usual care. Outcomes were hospital admissions, causes thereof, and patient and caregiver perceptions of place of care (home, hospital, etc.) at baseline, four weeks, eight weeks, and six months.RESULTS: During the study, 340 patients were randomized and 322 were included in modified intention-to-treat analyses. Overall, there were no significant differences in hospital admissions between the groups. The intervention group had more admissions triggered by worsened general health (22% vs. 16%, P = 0.0436) or unmanageable home situation (8% vs. 4%, P = 0.0119). After diagnostics, admissions were more often caused by clinical symptoms of cancer without progression in the intervention group (11% vs. 7%, P = 0.0493). The two groups did not differ significantly in overall potentially avoidable admissions. Both groups felt mostly safe about their place of care.CONCLUSION: The intervention did not prevent hospital admissions. Likely, any intervention effects were outweighed by increased identification of problems in the intervention group leading to hospital admissions. Overall, patients and caregivers felt safe in their current place of care.

AB - CONTEXT: Avoidable hospital admissions are important negative indicators of quality of end-of-life care. Specialized palliative care (SPC) may support patients remaining at home.OBJECTIVES: Therefore, the purpose of this study was to investigate if SPC at home could prevent hospital admissions in patients with incurable cancer.METHODS: These are secondary results of Domus: a randomized controlled trial of accelerated transition to SPC with psychological intervention at home (Clinicaltrials.gov: NCT01885637). Participants were patients with incurable cancer and limited antineoplastic treatment options and their caregivers. They were included from the Department of Oncology, Rigshospitalet, Denmark, between 2013 and 2016. The control group received usual care. Outcomes were hospital admissions, causes thereof, and patient and caregiver perceptions of place of care (home, hospital, etc.) at baseline, four weeks, eight weeks, and six months.RESULTS: During the study, 340 patients were randomized and 322 were included in modified intention-to-treat analyses. Overall, there were no significant differences in hospital admissions between the groups. The intervention group had more admissions triggered by worsened general health (22% vs. 16%, P = 0.0436) or unmanageable home situation (8% vs. 4%, P = 0.0119). After diagnostics, admissions were more often caused by clinical symptoms of cancer without progression in the intervention group (11% vs. 7%, P = 0.0493). The two groups did not differ significantly in overall potentially avoidable admissions. Both groups felt mostly safe about their place of care.CONCLUSION: The intervention did not prevent hospital admissions. Likely, any intervention effects were outweighed by increased identification of problems in the intervention group leading to hospital admissions. Overall, patients and caregivers felt safe in their current place of care.

U2 - 10.1016/j.jpainsymman.2017.10.007

DO - 10.1016/j.jpainsymman.2017.10.007

M3 - Journal article

C2 - 29056562

SN - 0885-3924

VL - 55

SP - 728

EP - 736

JO - Journal of Pain and Symptom Management

JF - Journal of Pain and Symptom Management

IS - 3

ER -

Causes of Hospital Admissions in Domus: A Randomized Controlled Trial of Specialized Palliative Cancer Care at Home

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