Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

Gian Andri Thun; Medea Imboden; Ilaria Ferrarotti; Ashish Kumar; Ma'en Obeidat; Michele Zorzetto; Margot Haun; Ivan Curjuric; Alexessander Couto Alves; Victoria E. Jackson; Eva Albrecht; Janina S. Ried; Alexander Teumer; Lorna M. Lopez; Jennifer E. Huffman; Stefan Enroth; Yohan Bosse; Ke Hao; Wim Timens; Ulf Gyllensten; Ozren Polasek; James F. Wilson; Igor Rudan; Caroline Hayward; Andrew J. Sandford; Ian J. Deary; Beate Koch; Eva Reischl; Holger Schulz; Jennie Hui; Alan L. James; Thierry Rochat; Erich W. Russi; Marjo-Riitta Jarvelin; David P. Strachan; Ian P. Hall; Martin D. Tobin; Morten Dahl; Sune Fallgaard Nielsen; Borge G. Nordestgaard; Florian Kronenberg; Maurizio Luisetti; Nicole M. Probst-Hensch

doi:10.1371/journal.pgen.1003585

Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

Gian Andri Thun, Medea Imboden, Ilaria Ferrarotti, Ashish Kumar, Ma'en Obeidat, Michele Zorzetto, Margot Haun, Ivan Curjuric, Alexessander Couto Alves, Victoria E. Jackson, Eva Albrecht, Janina S. Ried, Alexander Teumer, Lorna M. Lopez, Jennifer E. Huffman, Stefan Enroth, Yohan Bosse, Ke Hao, Wim Timens, Ulf GyllenstenOzren Polasek, James F. Wilson, Igor Rudan, Caroline Hayward, Andrew J. Sandford, Ian J. Deary, Beate Koch, Eva Reischl, Holger Schulz, Jennie Hui, Alan L. James, Thierry Rochat, Erich W. Russi, Marjo-Riitta Jarvelin, David P. Strachan, Ian P. Hall, Martin D. Tobin, Morten Dahl, Sune Fallgaard Nielsen, Borge G. Nordestgaard, Florian Kronenberg, Maurizio Luisetti, Nicole M. Probst-Hensch

Department of Clinical Medicine

Original language	English
Journal	PLOS Genetics
Volume	9
Issue number	8
ISSN	1553-7404
DOIs	https://doi.org/10.1371/journal.pgen.1003585
Publication status	Published - Aug 2013

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Thun, G. A., Imboden, M., Ferrarotti, I., Kumar, A., Obeidat, M., Zorzetto, M., Haun, M., Curjuric, I., Alves, A. C., Jackson, V. E., Albrecht, E., Ried, J. S., Teumer, A., Lopez, L. M., Huffman, J. E., Enroth, S., Bosse, Y., Hao, K., Timens, W., ... Probst-Hensch, N. M. (2013). Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels. PLOS Genetics, 9(8). https://doi.org/10.1371/journal.pgen.1003585

Thun, GA, Imboden, M, Ferrarotti, I, Kumar, A, Obeidat, M, Zorzetto, M, Haun, M, Curjuric, I, Alves, AC, Jackson, VE, Albrecht, E, Ried, JS, Teumer, A, Lopez, LM, Huffman, JE, Enroth, S, Bosse, Y, Hao, K, Timens, W, Gyllensten, U, Polasek, O, Wilson, JF, Rudan, I, Hayward, C, Sandford, AJ, Deary, IJ, Koch, B, Reischl, E, Schulz, H, Hui, J, James, AL, Rochat, T, Russi, EW, Jarvelin, M-R, Strachan, DP, Hall, IP, Tobin, MD, Dahl, M, Nielsen, SF, Nordestgaard, BG, Kronenberg, F, Luisetti, M & Probst-Hensch, NM 2013, 'Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels', PLOS Genetics, vol. 9, no. 8. https://doi.org/10.1371/journal.pgen.1003585

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title = "Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels",

author = "Thun, {Gian Andri} and Medea Imboden and Ilaria Ferrarotti and Ashish Kumar and Ma'en Obeidat and Michele Zorzetto and Margot Haun and Ivan Curjuric and Alves, {Alexessander Couto} and Jackson, {Victoria E.} and Eva Albrecht and Ried, {Janina S.} and Alexander Teumer and Lopez, {Lorna M.} and Huffman, {Jennifer E.} and Stefan Enroth and Yohan Bosse and Ke Hao and Wim Timens and Ulf Gyllensten and Ozren Polasek and Wilson, {James F.} and Igor Rudan and Caroline Hayward and Sandford, {Andrew J.} and Deary, {Ian J.} and Beate Koch and Eva Reischl and Holger Schulz and Jennie Hui and James, {Alan L.} and Thierry Rochat and Russi, {Erich W.} and Marjo-Riitta Jarvelin and Strachan, {David P.} and Hall, {Ian P.} and Tobin, {Martin D.} and Morten Dahl and Nielsen, {Sune Fallgaard} and Nordestgaard, {Borge G.} and Florian Kronenberg and Maurizio Luisetti and Probst-Hensch, {Nicole M.}",

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doi = "10.1371/journal.pgen.1003585",

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T1 - Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

AU - Thun, Gian Andri

AU - Imboden, Medea

AU - Ferrarotti, Ilaria

AU - Kumar, Ashish

AU - Obeidat, Ma'en

AU - Zorzetto, Michele

AU - Haun, Margot

AU - Curjuric, Ivan

AU - Alves, Alexessander Couto

AU - Jackson, Victoria E.

AU - Albrecht, Eva

AU - Ried, Janina S.

AU - Teumer, Alexander

AU - Lopez, Lorna M.

AU - Huffman, Jennifer E.

AU - Enroth, Stefan

AU - Bosse, Yohan

AU - Hao, Ke

AU - Timens, Wim

AU - Gyllensten, Ulf

AU - Polasek, Ozren

AU - Wilson, James F.

AU - Rudan, Igor

AU - Hayward, Caroline

AU - Sandford, Andrew J.

AU - Deary, Ian J.

AU - Koch, Beate

AU - Reischl, Eva

AU - Schulz, Holger

AU - Hui, Jennie

AU - James, Alan L.

AU - Rochat, Thierry

AU - Russi, Erich W.

AU - Jarvelin, Marjo-Riitta

AU - Strachan, David P.

AU - Hall, Ian P.

AU - Tobin, Martin D.

AU - Dahl, Morten

AU - Nielsen, Sune Fallgaard

AU - Nordestgaard, Borge G.

AU - Kronenberg, Florian

AU - Luisetti, Maurizio

AU - Probst-Hensch, Nicole M.

PY - 2013/8

Y1 - 2013/8

U2 - 10.1371/journal.pgen.1003585

DO - 10.1371/journal.pgen.1003585

M3 - Journal article

SN - 1553-7390

VL - 9

JO - P L o S Genetics

JF - P L o S Genetics

IS - 8

ER -

Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

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