Catching Lipid Droplet Contacts by Proteomics

TY - JOUR

T1 - Catching Lipid Droplet Contacts by Proteomics

AU - Krahmer, Natalie

AU - Mann, Matthias

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.

AB - Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.

U2 - 10.1177/2515256419859186

DO - 10.1177/2515256419859186

M3 - Review

C2 - 31355355

SN - 2515-2564

VL - 2

SP - 1

EP - 8

JO - Contact

JF - Contact

ER -