Catch You on the Flip Side: A Critical Review of Flippase Mutant Phenotypes

Sebastian J. Nintemann; Michael Palmgren; Rosa Laura López-Marqués

doi:10.1016/j.tplants.2019.02.002

Catch You on the Flip Side: A Critical Review of Flippase Mutant Phenotypes

Sebastian J. Nintemann, Michael Palmgren, Rosa Laura López-Marqués^*

^*Corresponding author for this work

Section for Transport Biology

11 Citations (Scopus)

Abstract

Lipid flippases are integral membrane proteins that use ATP hydrolysis to power the generation of phospholipid asymmetry between the two leaflets of biological membranes, a process essential for cell survival. Although the first report of a plant lipid flippase was published in 2000, progress in the field has been slow, partially due to the high level of redundancy in this gene family. However, recently an increasing number of reports have examined the physiological function of lipid flippases, mainly in Arabidopsis thaliana. In this review we aim to summarize recent findings on the physiological relevance of lipid flippases in plant adaptation to a changing environment and caution against misinterpretation of pleiotropic effects in genetic studies of flippases.

Original language	English
Journal	Trends in Plant Science
Volume	24
Issue number	5
Pages (from-to)	468-478
ISSN	1360-1385
DOIs	https://doi.org/10.1016/j.tplants.2019.02.002
Publication status	Published - 1 May 2019

Keywords

abiotic stress
biotic stress
lipid flippases
membrane function
P4 ATPases
plant development

Access to Document

10.1016/j.tplants.2019.02.002

Cite this

@article{ffc68165ee0043d787b79a604dd47f6a,

title = "Catch You on the Flip Side: A Critical Review of Flippase Mutant Phenotypes",

abstract = "Lipid flippases are integral membrane proteins that use ATP hydrolysis to power the generation of phospholipid asymmetry between the two leaflets of biological membranes, a process essential for cell survival. Although the first report of a plant lipid flippase was published in 2000, progress in the field has been slow, partially due to the high level of redundancy in this gene family. However, recently an increasing number of reports have examined the physiological function of lipid flippases, mainly in Arabidopsis thaliana. In this review we aim to summarize recent findings on the physiological relevance of lipid flippases in plant adaptation to a changing environment and caution against misinterpretation of pleiotropic effects in genetic studies of flippases.",

keywords = "abiotic stress, biotic stress, lipid flippases, membrane function, P4 ATPases, plant development",

author = "Nintemann, {Sebastian J.} and Michael Palmgren and L{\'o}pez-Marqu{\'e}s, {Rosa Laura}",

year = "2019",

month = may,

day = "1",

doi = "10.1016/j.tplants.2019.02.002",

language = "English",

volume = "24",

pages = "468--478",

journal = "Trends in Plant Science",

issn = "1360-1385",

publisher = "Elsevier Ltd. * Trends Journals",

number = "5",

}

TY - JOUR

T1 - Catch You on the Flip Side

T2 - A Critical Review of Flippase Mutant Phenotypes

AU - Nintemann, Sebastian J.

AU - Palmgren, Michael

AU - López-Marqués, Rosa Laura

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Lipid flippases are integral membrane proteins that use ATP hydrolysis to power the generation of phospholipid asymmetry between the two leaflets of biological membranes, a process essential for cell survival. Although the first report of a plant lipid flippase was published in 2000, progress in the field has been slow, partially due to the high level of redundancy in this gene family. However, recently an increasing number of reports have examined the physiological function of lipid flippases, mainly in Arabidopsis thaliana. In this review we aim to summarize recent findings on the physiological relevance of lipid flippases in plant adaptation to a changing environment and caution against misinterpretation of pleiotropic effects in genetic studies of flippases.

AB - Lipid flippases are integral membrane proteins that use ATP hydrolysis to power the generation of phospholipid asymmetry between the two leaflets of biological membranes, a process essential for cell survival. Although the first report of a plant lipid flippase was published in 2000, progress in the field has been slow, partially due to the high level of redundancy in this gene family. However, recently an increasing number of reports have examined the physiological function of lipid flippases, mainly in Arabidopsis thaliana. In this review we aim to summarize recent findings on the physiological relevance of lipid flippases in plant adaptation to a changing environment and caution against misinterpretation of pleiotropic effects in genetic studies of flippases.

KW - abiotic stress

KW - biotic stress

KW - lipid flippases

KW - membrane function

KW - P4 ATPases

KW - plant development

UR - http://www.scopus.com/inward/record.url?scp=85062956736&partnerID=8YFLogxK

U2 - 10.1016/j.tplants.2019.02.002

DO - 10.1016/j.tplants.2019.02.002

M3 - Review

C2 - 30885637

AN - SCOPUS:85062956736

SN - 1360-1385

VL - 24

SP - 468

EP - 478

JO - Trends in Plant Science

JF - Trends in Plant Science

IS - 5

ER -

Catch You on the Flip Side: A Critical Review of Flippase Mutant Phenotypes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this