Ca²⁺ -Mediated Plateau Potentials in a Subpopulation of Interneurons in the Ventral Horn of the Turtle Spinal Cord.

TY - JOUR

T1 - Ca2+ -Mediated Plateau Potentials in a Subpopulation of Interneurons in the Ventral Horn of the Turtle Spinal Cord.

AU - Hounsgaard, J.

AU - Kjaerulff, O.

PY - 1992

Y1 - 1992

N2 - The response properties of interneurons in the ventral horn were studied in transverse slices of segments D8 to S2 from the turtle spinal cord, using the current clamp technique. In about half of the neurons the response properties were dominated by their ability to generate plateau potentials. In these cells the plateau potential could account for delayed onset of spiking and a phase of increasing spike frequency during depolarizing current pulses and for a depolarizing afterpotential following the stimulus. The cells usually received monosynaptic and polysynaptic input from the ipsilateral dorsal root and occasionally from the contralateral root. The plateau potential was insensitive to tetrodotoxin but blocked by nifedipine and by replacing Ca2+ with Co2+ in the medium. It is concluded that the response properties of neurons in the ventral horn outside the motor nucleus have differentiated response properties that may well contribute to spinal motor function.

AB - The response properties of interneurons in the ventral horn were studied in transverse slices of segments D8 to S2 from the turtle spinal cord, using the current clamp technique. In about half of the neurons the response properties were dominated by their ability to generate plateau potentials. In these cells the plateau potential could account for delayed onset of spiking and a phase of increasing spike frequency during depolarizing current pulses and for a depolarizing afterpotential following the stimulus. The cells usually received monosynaptic and polysynaptic input from the ipsilateral dorsal root and occasionally from the contralateral root. The plateau potential was insensitive to tetrodotoxin but blocked by nifedipine and by replacing Ca2+ with Co2+ in the medium. It is concluded that the response properties of neurons in the ventral horn outside the motor nucleus have differentiated response properties that may well contribute to spinal motor function.

M3 - Journal article

C2 - 12106381

SN - 0953-816X

VL - 4

SP - 183

EP - 188

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

IS - 2

ER -