Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance

Louise Lundby-Christensen; Lise Tarnow; Dorte L Hansen; Dorte Worm; Lars S Naver; Lisbeth E Hvolris; Niels Wiinberg; Allan Vaag; Thomas P Almdal

doi:10.1016/j.jdiacomp.2014.03.005

Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance

Louise Lundby-Christensen, Lise Tarnow, Dorte L Hansen, Dorte Worm, Lars S Naver, Lisbeth E Hvolris, Niels Wiinberg, Allan Vaag, Thomas P Almdal

Department of Clinical Medicine

17 Citations (Scopus)

Abstract

Aim To investigate whether Roux-en-Y gastric bypass surgery (RYGB) - an in vivo model for normalisation of hyperglycaemia - improves carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2D)/impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). Methods Observational prospective study, 34 obese patients (T2D (n = 14)/IGT (n = 4), and NGT (n = 16)) were investigated before and six and 12 months after RYGB. Results Mean carotid IMT was significantly reduced 12 months after RYGB in patients with T2D/IGT (- 0.041 mm (95% CI - 0.069; - 0.012, p = 0.005)) but not in patients with NGT (- 0.010 mm (- 0.039; 0.020, p = 0.52)). The between-group difference was not significant (p = 0.13). Twelve months after RYGB, patients with respectively T2D/IGT and NGT demonstrated changes in weight: - 29.9 kg, p < 0.001/- 30.6 kg, p < 0.001, HbA1c: - 0.7%, p < 0.001/- 0.1%, p = 0.33, systolic blood pressure: - 2 mmHg, p = 0.68/- 10 mmHg, p = 0.01 and diastolic blood pressure: - 8 mmHg, p = 0.003/- 11 mmHg, p < 0.001. 80% of T2D patients terminated antihyperglycaemic medication. Conclusion Mean carotid IMT was significantly reduced 12 months after RYGB in patients with T2D/IGT which provides evidence to support that the earliest atherosclerotic changes in the arterial wall are reversible. Although numerically different from the changes observed in patients with NGT, the between-group difference was not statistically significant.

Original language	English
Journal	Journal of Diabetes and its Complications
Volume	28
Issue number	4
Pages (from-to)	517-522
Number of pages	6
ISSN	1056-8727
DOIs	https://doi.org/10.1016/j.jdiacomp.2014.03.005
Publication status	Published - 2 Apr 2014

Keywords

Adolescent
Adult
Body Mass Index
Carotid Intima-Media Thickness
Denmark
Diabetes Mellitus, Type 2
Diabetic Angiopathies
Down-Regulation
Female
Gastric Bypass
Glucose Intolerance
Hemoglobin A, Glycosylated
Humans
Hyperglycemia
Hypertension
Male
Middle Aged
Obesity, Morbid
Risk Factors
Vascular Diseases
Weight Loss
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jdiacomp.2014.03.005

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Lundby-Christensen, L., Tarnow, L., Hansen, D. L., Worm, D., Naver, L. S., Hvolris, L. E., Wiinberg, N., Vaag, A., & Almdal, T. P. (2014). Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance. Journal of Diabetes and its Complications, 28(4), 517-522. https://doi.org/10.1016/j.jdiacomp.2014.03.005

Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance. / Lundby-Christensen, Louise; Tarnow, Lise; Hansen, Dorte L et al.
In: Journal of Diabetes and its Complications, Vol. 28, No. 4, 02.04.2014, p. 517-522.

Research output: Contribution to journal › Journal article › Research › peer-review

Lundby-Christensen, L, Tarnow, L, Hansen, DL, Worm, D, Naver, LS, Hvolris, LE, Wiinberg, N, Vaag, A & Almdal, TP 2014, 'Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance', Journal of Diabetes and its Complications, vol. 28, no. 4, pp. 517-522. https://doi.org/10.1016/j.jdiacomp.2014.03.005

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title = "Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance",

abstract = "Aim To investigate whether Roux-en-Y gastric bypass surgery (RYGB) - an in vivo model for normalisation of hyperglycaemia - improves carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2D)/impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). Methods Observational prospective study, 34 obese patients (T2D (n = 14)/IGT (n = 4), and NGT (n = 16)) were investigated before and six and 12 months after RYGB. Results Mean carotid IMT was significantly reduced 12 months after RYGB in patients with T2D/IGT (- 0.041 mm (95% CI - 0.069; - 0.012, p = 0.005)) but not in patients with NGT (- 0.010 mm (- 0.039; 0.020, p = 0.52)). The between-group difference was not significant (p = 0.13). Twelve months after RYGB, patients with respectively T2D/IGT and NGT demonstrated changes in weight: - 29.9 kg, p < 0.001/- 30.6 kg, p < 0.001, HbA1c: - 0.7%, p < 0.001/- 0.1%, p = 0.33, systolic blood pressure: - 2 mmHg, p = 0.68/- 10 mmHg, p = 0.01 and diastolic blood pressure: - 8 mmHg, p = 0.003/- 11 mmHg, p < 0.001. 80% of T2D patients terminated antihyperglycaemic medication. Conclusion Mean carotid IMT was significantly reduced 12 months after RYGB in patients with T2D/IGT which provides evidence to support that the earliest atherosclerotic changes in the arterial wall are reversible. Although numerically different from the changes observed in patients with NGT, the between-group difference was not statistically significant.",

keywords = "Adolescent, Adult, Body Mass Index, Carotid Intima-Media Thickness, Denmark, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Down-Regulation, Female, Gastric Bypass, Glucose Intolerance, Hemoglobin A, Glycosylated, Humans, Hyperglycemia, Hypertension, Male, Middle Aged, Obesity, Morbid, Risk Factors, Vascular Diseases, Weight Loss, Young Adult",

author = "Louise Lundby-Christensen and Lise Tarnow and Hansen, {Dorte L} and Dorte Worm and Naver, {Lars S} and Hvolris, {Lisbeth E} and Niels Wiinberg and Allan Vaag and Almdal, {Thomas P}",

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T1 - Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance

AU - Lundby-Christensen, Louise

AU - Tarnow, Lise

AU - Hansen, Dorte L

AU - Worm, Dorte

AU - Naver, Lars S

AU - Hvolris, Lisbeth E

AU - Wiinberg, Niels

AU - Vaag, Allan

AU - Almdal, Thomas P

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N2 - Aim To investigate whether Roux-en-Y gastric bypass surgery (RYGB) - an in vivo model for normalisation of hyperglycaemia - improves carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2D)/impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). Methods Observational prospective study, 34 obese patients (T2D (n = 14)/IGT (n = 4), and NGT (n = 16)) were investigated before and six and 12 months after RYGB. Results Mean carotid IMT was significantly reduced 12 months after RYGB in patients with T2D/IGT (- 0.041 mm (95% CI - 0.069; - 0.012, p = 0.005)) but not in patients with NGT (- 0.010 mm (- 0.039; 0.020, p = 0.52)). The between-group difference was not significant (p = 0.13). Twelve months after RYGB, patients with respectively T2D/IGT and NGT demonstrated changes in weight: - 29.9 kg, p < 0.001/- 30.6 kg, p < 0.001, HbA1c: - 0.7%, p < 0.001/- 0.1%, p = 0.33, systolic blood pressure: - 2 mmHg, p = 0.68/- 10 mmHg, p = 0.01 and diastolic blood pressure: - 8 mmHg, p = 0.003/- 11 mmHg, p < 0.001. 80% of T2D patients terminated antihyperglycaemic medication. Conclusion Mean carotid IMT was significantly reduced 12 months after RYGB in patients with T2D/IGT which provides evidence to support that the earliest atherosclerotic changes in the arterial wall are reversible. Although numerically different from the changes observed in patients with NGT, the between-group difference was not statistically significant.

AB - Aim To investigate whether Roux-en-Y gastric bypass surgery (RYGB) - an in vivo model for normalisation of hyperglycaemia - improves carotid intima-media thickness (IMT) in patients with type 2 diabetes (T2D)/impaired glucose tolerance (IGT) and normal glucose tolerance (NGT). Methods Observational prospective study, 34 obese patients (T2D (n = 14)/IGT (n = 4), and NGT (n = 16)) were investigated before and six and 12 months after RYGB. Results Mean carotid IMT was significantly reduced 12 months after RYGB in patients with T2D/IGT (- 0.041 mm (95% CI - 0.069; - 0.012, p = 0.005)) but not in patients with NGT (- 0.010 mm (- 0.039; 0.020, p = 0.52)). The between-group difference was not significant (p = 0.13). Twelve months after RYGB, patients with respectively T2D/IGT and NGT demonstrated changes in weight: - 29.9 kg, p < 0.001/- 30.6 kg, p < 0.001, HbA1c: - 0.7%, p < 0.001/- 0.1%, p = 0.33, systolic blood pressure: - 2 mmHg, p = 0.68/- 10 mmHg, p = 0.01 and diastolic blood pressure: - 8 mmHg, p = 0.003/- 11 mmHg, p < 0.001. 80% of T2D patients terminated antihyperglycaemic medication. Conclusion Mean carotid IMT was significantly reduced 12 months after RYGB in patients with T2D/IGT which provides evidence to support that the earliest atherosclerotic changes in the arterial wall are reversible. Although numerically different from the changes observed in patients with NGT, the between-group difference was not statistically significant.

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KW - Adult

KW - Body Mass Index

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KW - Diabetes Mellitus, Type 2

KW - Diabetic Angiopathies

KW - Down-Regulation

KW - Female

KW - Gastric Bypass

KW - Glucose Intolerance

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Hyperglycemia

KW - Hypertension

KW - Male

KW - Middle Aged

KW - Obesity, Morbid

KW - Risk Factors

KW - Vascular Diseases

KW - Weight Loss

KW - Young Adult

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DO - 10.1016/j.jdiacomp.2014.03.005

M3 - Journal article

C2 - 24685364

SN - 1056-8727

VL - 28

SP - 517

EP - 522

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 4

ER -

Carotid intima-media thickness is reduced 12 months after gastric bypass surgery in obese patients with type 2 diabetes or impaired glucose tolerance

Abstract

Keywords

UN SDGs

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