Cardiac function in offspring of women with diabetes using fetal ECG, umbilical cord blood pro-BNP, and neonatal interventricular septal thickness

Karen Halse; Marie Louise Skakkebæk Lindegaard; Isis Amer-Wahlin; Steen Hertel; Marianne Johansen; Lars Bo Nielsen; Jens Peter Gøtze; Elisabeth Reinhardt Mathiesen; Peter Damm

doi:10.1097/xce.0b013e328362e3f2

Cardiac function in offspring of women with diabetes using fetal ECG, umbilical cord blood pro-BNP, and neonatal interventricular septal thickness

Karen Halse, Marie Louise Skakkebæk Lindegaard, Isis Amer-Wahlin, Steen Hertel, Marianne Johansen, Lars Bo Nielsen, Jens Peter Gøtze, Elisabeth Reinhardt Mathiesen, Peter Damm

Abstract

Objective: Increased pro-brain natriuretic peptide (BNP) concentrations in newborns of diabetic women are associated with fetal stress, and fetal ECG changes often occur in labor in diabetic women. These findings could reflect a degree of fetal cardiomyopathy. We aimed to explore possible relations between serological and morphological markers of cardiac dysfunction and abnormal changes on fetal ECGs during labor and delivery in pregnancies complicated by diabetes. Materials and methods: Pregnant women with diabetes (30 type 1, nine type 2, and 60 gestational diabetes) and their newborn offspring were included prospectively. Umbilical cord blood pro-BNP concentrations were measured immediately after delivery (n= 68) and echocardiography was performed in the newborns (n =75). Fetal ECG in combination with cardiotocography, that is STAN technology was also performed during labor. Results: The concentration of umbilical cord blood pro-BNP was associated positively with the neonatal cardiac interventricular septal thickness (P =0.025) and associated negatively with umbilical cord blood pH levels (P = 0.036). Fetal ECG changes (STAN events) were recorded in 22 of 53 labors where STAN was used (42%). No correlation was observed between interventricular septal thickness and STAN events. Conclusion: Increased umbilical cord blood pro-BNP is associated with echocardiographic signs of cardiomyopathy and with lower umbilical cord blood pH.

Original language	English
Journal	Cardiovascular Endocrinology
Volume	2
Issue number	3
Pages (from-to)	55-59
Number of pages	5
ISSN	2162-6898
DOIs	https://doi.org/10.1097/xce.0b013e328362e3f2
Publication status	Published - 2013

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10.1097/xce.0b013e328362e3f2

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Halse, K., Lindegaard, M. L. S., Amer-Wahlin, I., Hertel, S., Johansen, M., Nielsen, L. B., Gøtze, J. P., Mathiesen, E. R., & Damm, P. (2013). Cardiac function in offspring of women with diabetes using fetal ECG, umbilical cord blood pro-BNP, and neonatal interventricular septal thickness. Cardiovascular Endocrinology, 2(3), 55-59. https://doi.org/10.1097/xce.0b013e328362e3f2

Cardiac function in offspring of women with diabetes using fetal ECG, umbilical cord blood pro-BNP, and neonatal interventricular septal thickness. / Halse, Karen; Lindegaard, Marie Louise Skakkebæk; Amer-Wahlin, Isis et al.

In: Cardiovascular Endocrinology, Vol. 2, No. 3, 2013, p. 55-59.

Research output: Contribution to journal › Journal article › Research › peer-review

Halse, K, Lindegaard, MLS, Amer-Wahlin, I, Hertel, S, Johansen, M, Nielsen, LB, Gøtze, JP , Mathiesen, ER & Damm, P 2013, 'Cardiac function in offspring of women with diabetes using fetal ECG, umbilical cord blood pro-BNP, and neonatal interventricular septal thickness', Cardiovascular Endocrinology, vol. 2, no. 3, pp. 55-59. https://doi.org/10.1097/xce.0b013e328362e3f2

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title = "Cardiac function in offspring of women with diabetes using fetal ECG, umbilical cord blood pro-BNP, and neonatal interventricular septal thickness",

abstract = "Objective: Increased pro-brain natriuretic peptide (BNP) concentrations in newborns of diabetic women are associated with fetal stress, and fetal ECG changes often occur in labor in diabetic women. These findings could reflect a degree of fetal cardiomyopathy. We aimed to explore possible relations between serological and morphological markers of cardiac dysfunction and abnormal changes on fetal ECGs during labor and delivery in pregnancies complicated by diabetes. Materials and methods: Pregnant women with diabetes (30 type 1, nine type 2, and 60 gestational diabetes) and their newborn offspring were included prospectively. Umbilical cord blood pro-BNP concentrations were measured immediately after delivery (n= 68) and echocardiography was performed in the newborns (n =75). Fetal ECG in combination with cardiotocography, that is STAN technology was also performed during labor. Results: The concentration of umbilical cord blood pro-BNP was associated positively with the neonatal cardiac interventricular septal thickness (P =0.025) and associated negatively with umbilical cord blood pH levels (P = 0.036). Fetal ECG changes (STAN events) were recorded in 22 of 53 labors where STAN was used (42%). No correlation was observed between interventricular septal thickness and STAN events. Conclusion: Increased umbilical cord blood pro-BNP is associated with echocardiographic signs of cardiomyopathy and with lower umbilical cord blood pH.",

author = "Karen Halse and Lindegaard, {Marie Louise Skakkeb{\ae}k} and Isis Amer-Wahlin and Steen Hertel and Marianne Johansen and Nielsen, {Lars Bo} and G{\o}tze, {Jens Peter} and Mathiesen, {Elisabeth Reinhardt} and Peter Damm",

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T1 - Cardiac function in offspring of women with diabetes using fetal ECG, umbilical cord blood pro-BNP, and neonatal interventricular septal thickness

AU - Halse, Karen

AU - Lindegaard, Marie Louise Skakkebæk

AU - Amer-Wahlin, Isis

AU - Hertel, Steen

AU - Johansen, Marianne

AU - Nielsen, Lars Bo

AU - Gøtze, Jens Peter

AU - Mathiesen, Elisabeth Reinhardt

AU - Damm, Peter

PY - 2013

Y1 - 2013

N2 - Objective: Increased pro-brain natriuretic peptide (BNP) concentrations in newborns of diabetic women are associated with fetal stress, and fetal ECG changes often occur in labor in diabetic women. These findings could reflect a degree of fetal cardiomyopathy. We aimed to explore possible relations between serological and morphological markers of cardiac dysfunction and abnormal changes on fetal ECGs during labor and delivery in pregnancies complicated by diabetes. Materials and methods: Pregnant women with diabetes (30 type 1, nine type 2, and 60 gestational diabetes) and their newborn offspring were included prospectively. Umbilical cord blood pro-BNP concentrations were measured immediately after delivery (n= 68) and echocardiography was performed in the newborns (n =75). Fetal ECG in combination with cardiotocography, that is STAN technology was also performed during labor. Results: The concentration of umbilical cord blood pro-BNP was associated positively with the neonatal cardiac interventricular septal thickness (P =0.025) and associated negatively with umbilical cord blood pH levels (P = 0.036). Fetal ECG changes (STAN events) were recorded in 22 of 53 labors where STAN was used (42%). No correlation was observed between interventricular septal thickness and STAN events. Conclusion: Increased umbilical cord blood pro-BNP is associated with echocardiographic signs of cardiomyopathy and with lower umbilical cord blood pH.

AB - Objective: Increased pro-brain natriuretic peptide (BNP) concentrations in newborns of diabetic women are associated with fetal stress, and fetal ECG changes often occur in labor in diabetic women. These findings could reflect a degree of fetal cardiomyopathy. We aimed to explore possible relations between serological and morphological markers of cardiac dysfunction and abnormal changes on fetal ECGs during labor and delivery in pregnancies complicated by diabetes. Materials and methods: Pregnant women with diabetes (30 type 1, nine type 2, and 60 gestational diabetes) and their newborn offspring were included prospectively. Umbilical cord blood pro-BNP concentrations were measured immediately after delivery (n= 68) and echocardiography was performed in the newborns (n =75). Fetal ECG in combination with cardiotocography, that is STAN technology was also performed during labor. Results: The concentration of umbilical cord blood pro-BNP was associated positively with the neonatal cardiac interventricular septal thickness (P =0.025) and associated negatively with umbilical cord blood pH levels (P = 0.036). Fetal ECG changes (STAN events) were recorded in 22 of 53 labors where STAN was used (42%). No correlation was observed between interventricular septal thickness and STAN events. Conclusion: Increased umbilical cord blood pro-BNP is associated with echocardiographic signs of cardiomyopathy and with lower umbilical cord blood pH.

U2 - 10.1097/xce.0b013e328362e3f2

DO - 10.1097/xce.0b013e328362e3f2

M3 - Journal article

SN - 2162-6898

VL - 2

SP - 55

EP - 59

JO - Cardiovascular Endocrinology

JF - Cardiovascular Endocrinology

IS - 3

ER -

Cardiac function in offspring of women with diabetes using fetal ECG, umbilical cord blood pro-BNP, and neonatal interventricular septal thickness

Abstract

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