Cardiac arrhythmias in adult patients with asthma

Miriam J Warnier; Frans H Rutten; Jan A Kors; Jan Willem J Lammers; Anthonius de Boer; Arno W Hoes; Marie L de Bruin

doi:10.3109/02770903.2012.724132

Cardiac arrhythmias in adult patients with asthma

Miriam J Warnier, Frans H Rutten, Jan A Kors, Jan Willem J Lammers, Anthonius de Boer, Arno W Hoes, Marie L de Bruin

15 Citations (Scopus)

Abstract

Objective. The pathogenesis of cardiac arrhythmias in asthma patients has not been fully elucidated. Adverse drug effects, particularly those of β2-mimetics, may play a role. The aim of this study was to determine whether asthma is associated with the risk of cardiac arrhythmias and electrocardiographic characteristics of arrhythmogenicity (ECG) and to explore the role of β2-mimetics. Methods. A cross-sectional study was conducted among 158 adult patients with a diagnosis of asthma and 6303 participants without asthma from the cohort of the Utrecht Health Projectan ongoing, longitudinal, primary care-based study. All patients underwent extensive examinations, including resting 12-lead electrocardiogram (ECG) and pulmonary function tests. The primary outcome was "any arrhythmia on the ECG" (including tachycardia, bradycardia, premature ventricular contraction (PVC), and atrial fibrillation or flutter). Secondary outcomes were tachycardia, bradycardia, PVC, atrial fibrillation or flutter, mean heart rate, mean corrected QT (QTc) interval length, and prolonged QTc interval. Results. Tachycardia and PVCs were more prevalent in patients with asthma (3 and 4, respectively) than those without asthma (0.6, p < .001; 2, p .03, respectively). The prevalence of QTc interval prolongation was similar in participants with (2) and without asthma (3, odds ratio [OR]: 0.6 and 95 confidence interval [95 CI]: 0.22.0). In 74 asthma patients, who received β2-mimetics, tachycardia and PVCs were more common (OR: 12.4 [95 CI: 4.732.8] and 3.7 [95 CI: 1.310.5], respectively). Conclusions. The adult patients with asthma more commonly show tachycardia and PVCs on the ECG than those without asthma. The patients with asthma received β2-mimetics; the risk of tachycardia and PVCs is even more pronounced.

Original language	English
Journal	Journal of Asthma
Volume	49
Issue number	9
Pages (from-to)	942-6
Number of pages	5
ISSN	0277-0903
DOIs	https://doi.org/10.3109/02770903.2012.724132
Publication status	Published - Nov 2012
Externally published	Yes

Keywords

Adrenergic beta-2 Receptor Agonists
Adult
Anti-Asthmatic Agents
Arrhythmias, Cardiac
Asthma
Atrial Fibrillation
Bradycardia
Cross-Sectional Studies
Electrocardiography
Female
Heart Rate
Humans
Male
Middle Aged
Prevalence
Respiratory Function Tests
Severity of Illness Index
Tachycardia, Ventricular
Ventricular Premature Complexes
Journal Article
Research Support, Non-U.S. Gov't

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10.3109/02770903.2012.724132

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@article{7f5bbddf3d684ebcad8cfbe39381c2b0,

title = "Cardiac arrhythmias in adult patients with asthma",

abstract = "Objective. The pathogenesis of cardiac arrhythmias in asthma patients has not been fully elucidated. Adverse drug effects, particularly those of β2-mimetics, may play a role. The aim of this study was to determine whether asthma is associated with the risk of cardiac arrhythmias and electrocardiographic characteristics of arrhythmogenicity (ECG) and to explore the role of β2-mimetics. Methods. A cross-sectional study was conducted among 158 adult patients with a diagnosis of asthma and 6303 participants without asthma from the cohort of the Utrecht Health Projectan ongoing, longitudinal, primary care-based study. All patients underwent extensive examinations, including resting 12-lead electrocardiogram (ECG) and pulmonary function tests. The primary outcome was {"}any arrhythmia on the ECG{"} (including tachycardia, bradycardia, premature ventricular contraction (PVC), and atrial fibrillation or flutter). Secondary outcomes were tachycardia, bradycardia, PVC, atrial fibrillation or flutter, mean heart rate, mean corrected QT (QTc) interval length, and prolonged QTc interval. Results. Tachycardia and PVCs were more prevalent in patients with asthma (3 and 4, respectively) than those without asthma (0.6, p < .001; 2, p .03, respectively). The prevalence of QTc interval prolongation was similar in participants with (2) and without asthma (3, odds ratio [OR]: 0.6 and 95 confidence interval [95 CI]: 0.22.0). In 74 asthma patients, who received β2-mimetics, tachycardia and PVCs were more common (OR: 12.4 [95 CI: 4.732.8] and 3.7 [95 CI: 1.310.5], respectively). Conclusions. The adult patients with asthma more commonly show tachycardia and PVCs on the ECG than those without asthma. The patients with asthma received β2-mimetics; the risk of tachycardia and PVCs is even more pronounced.",

keywords = "Adrenergic beta-2 Receptor Agonists, Adult, Anti-Asthmatic Agents, Arrhythmias, Cardiac, Asthma, Atrial Fibrillation, Bradycardia, Cross-Sectional Studies, Electrocardiography, Female, Heart Rate, Humans, Male, Middle Aged, Prevalence, Respiratory Function Tests, Severity of Illness Index, Tachycardia, Ventricular, Ventricular Premature Complexes, Journal Article, Research Support, Non-U.S. Gov't",

author = "Warnier, {Miriam J} and Rutten, {Frans H} and Kors, {Jan A} and Lammers, {Jan Willem J} and {de Boer}, Anthonius and Hoes, {Arno W} and {de Bruin}, {Marie L}",

year = "2012",

month = nov,

doi = "10.3109/02770903.2012.724132",

language = "English",

volume = "49",

pages = "942--6",

journal = "Journal of Asthma",

issn = "0277-0903",

publisher = "Taylor & Francis",

number = "9",

}

TY - JOUR

T1 - Cardiac arrhythmias in adult patients with asthma

AU - Warnier, Miriam J

AU - Rutten, Frans H

AU - Kors, Jan A

AU - Lammers, Jan Willem J

AU - de Boer, Anthonius

AU - Hoes, Arno W

AU - de Bruin, Marie L

PY - 2012/11

Y1 - 2012/11

N2 - Objective. The pathogenesis of cardiac arrhythmias in asthma patients has not been fully elucidated. Adverse drug effects, particularly those of β2-mimetics, may play a role. The aim of this study was to determine whether asthma is associated with the risk of cardiac arrhythmias and electrocardiographic characteristics of arrhythmogenicity (ECG) and to explore the role of β2-mimetics. Methods. A cross-sectional study was conducted among 158 adult patients with a diagnosis of asthma and 6303 participants without asthma from the cohort of the Utrecht Health Projectan ongoing, longitudinal, primary care-based study. All patients underwent extensive examinations, including resting 12-lead electrocardiogram (ECG) and pulmonary function tests. The primary outcome was "any arrhythmia on the ECG" (including tachycardia, bradycardia, premature ventricular contraction (PVC), and atrial fibrillation or flutter). Secondary outcomes were tachycardia, bradycardia, PVC, atrial fibrillation or flutter, mean heart rate, mean corrected QT (QTc) interval length, and prolonged QTc interval. Results. Tachycardia and PVCs were more prevalent in patients with asthma (3 and 4, respectively) than those without asthma (0.6, p < .001; 2, p .03, respectively). The prevalence of QTc interval prolongation was similar in participants with (2) and without asthma (3, odds ratio [OR]: 0.6 and 95 confidence interval [95 CI]: 0.22.0). In 74 asthma patients, who received β2-mimetics, tachycardia and PVCs were more common (OR: 12.4 [95 CI: 4.732.8] and 3.7 [95 CI: 1.310.5], respectively). Conclusions. The adult patients with asthma more commonly show tachycardia and PVCs on the ECG than those without asthma. The patients with asthma received β2-mimetics; the risk of tachycardia and PVCs is even more pronounced.

AB - Objective. The pathogenesis of cardiac arrhythmias in asthma patients has not been fully elucidated. Adverse drug effects, particularly those of β2-mimetics, may play a role. The aim of this study was to determine whether asthma is associated with the risk of cardiac arrhythmias and electrocardiographic characteristics of arrhythmogenicity (ECG) and to explore the role of β2-mimetics. Methods. A cross-sectional study was conducted among 158 adult patients with a diagnosis of asthma and 6303 participants without asthma from the cohort of the Utrecht Health Projectan ongoing, longitudinal, primary care-based study. All patients underwent extensive examinations, including resting 12-lead electrocardiogram (ECG) and pulmonary function tests. The primary outcome was "any arrhythmia on the ECG" (including tachycardia, bradycardia, premature ventricular contraction (PVC), and atrial fibrillation or flutter). Secondary outcomes were tachycardia, bradycardia, PVC, atrial fibrillation or flutter, mean heart rate, mean corrected QT (QTc) interval length, and prolonged QTc interval. Results. Tachycardia and PVCs were more prevalent in patients with asthma (3 and 4, respectively) than those without asthma (0.6, p < .001; 2, p .03, respectively). The prevalence of QTc interval prolongation was similar in participants with (2) and without asthma (3, odds ratio [OR]: 0.6 and 95 confidence interval [95 CI]: 0.22.0). In 74 asthma patients, who received β2-mimetics, tachycardia and PVCs were more common (OR: 12.4 [95 CI: 4.732.8] and 3.7 [95 CI: 1.310.5], respectively). Conclusions. The adult patients with asthma more commonly show tachycardia and PVCs on the ECG than those without asthma. The patients with asthma received β2-mimetics; the risk of tachycardia and PVCs is even more pronounced.

KW - Adrenergic beta-2 Receptor Agonists

KW - Adult

KW - Anti-Asthmatic Agents

KW - Arrhythmias, Cardiac

KW - Asthma

KW - Atrial Fibrillation

KW - Bradycardia

KW - Cross-Sectional Studies

KW - Electrocardiography

KW - Female

KW - Heart Rate

KW - Humans

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Respiratory Function Tests

KW - Severity of Illness Index

KW - Tachycardia, Ventricular

KW - Ventricular Premature Complexes

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.3109/02770903.2012.724132

DO - 10.3109/02770903.2012.724132

M3 - Journal article

C2 - 23013453

SN - 0277-0903

VL - 49

SP - 942

EP - 946

JO - Journal of Asthma

JF - Journal of Asthma

IS - 9

ER -

Cardiac arrhythmias in adult patients with asthma

Abstract

Keywords

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