Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

Joseph Bouskila; Vanessa Harrar; Pasha Javadi; Amy Beierschmitt; Roberta Palmour; Christian Casanova; Jean-François Bouchard; Maurice Ptito

doi:10.1155/2016/1253245

Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

Joseph Bouskila, Vanessa Harrar, Pasha Javadi, Amy Beierschmitt, Roberta Palmour, Christian Casanova, Jean-François Bouchard, Maurice Ptito^*

^*Corresponding author for this work

7 Citations (Scopus)

42 Downloads (Pure)

Abstract

The expression patterns of the cannabinoid receptor type 1 (CB1R) and the cannabinoid receptor type 2 (CB2R) are well documented in rodents and primates. In vervet monkeys, CB1R is present in the retinal neurons (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells) and CB2R is exclusively found in the retinal glia (Müller cells). However, the role of these cannabinoid receptors in normal primate retinal function remains elusive. Using full-field electroretinography in adult vervet monkeys, we recorded changes in neural activity following the blockade of CB1R and CB2R by the intravitreal administration of their antagonists (AM251 and AM630, resp.) in photopic and scotopic conditions. Our results show that AM251 increases the photopic a-wave amplitude at high flash intensities, whereas AM630 increases the amplitude of both the photopic a- and b-waves. In scotopic conditions, both blockers increased the b-wave amplitude but did not change the a-wave amplitude. These findings suggest an important role of CB1R and CB2R in primate retinal function.

Original language	English
Article number	1253245
Journal	Neural Plasticity
Volume	2016
Number of pages	12
ISSN	2090-5904
DOIs	https://doi.org/10.1155/2016/1253245
Publication status	Published - 2016

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Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet MonkeysFinal published version, 2.51 MBLicence: CC BY

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@article{0f3a032ebd434dd29e7cc0fe09cfd15d,

title = "Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys",

abstract = "The expression patterns of the cannabinoid receptor type 1 (CB1R) and the cannabinoid receptor type 2 (CB2R) are well documented in rodents and primates. In vervet monkeys, CB1R is present in the retinal neurons (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells) and CB2R is exclusively found in the retinal glia (M{\"u}ller cells). However, the role of these cannabinoid receptors in normal primate retinal function remains elusive. Using full-field electroretinography in adult vervet monkeys, we recorded changes in neural activity following the blockade of CB1R and CB2R by the intravitreal administration of their antagonists (AM251 and AM630, resp.) in photopic and scotopic conditions. Our results show that AM251 increases the photopic a-wave amplitude at high flash intensities, whereas AM630 increases the amplitude of both the photopic a- and b-waves. In scotopic conditions, both blockers increased the b-wave amplitude but did not change the a-wave amplitude. These findings suggest an important role of CB1R and CB2R in primate retinal function.",

author = "Joseph Bouskila and Vanessa Harrar and Pasha Javadi and Amy Beierschmitt and Roberta Palmour and Christian Casanova and Jean-Fran{\c c}ois Bouchard and Maurice Ptito",

year = "2016",

doi = "10.1155/2016/1253245",

language = "English",

volume = "2016",

journal = "Neural Plasticity",

issn = "2090-5904",

publisher = "Hindawi Publishing Corporation",

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TY - JOUR

T1 - Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

AU - Bouskila, Joseph

AU - Harrar, Vanessa

AU - Javadi, Pasha

AU - Beierschmitt, Amy

AU - Palmour, Roberta

AU - Casanova, Christian

AU - Bouchard, Jean-François

AU - Ptito, Maurice

PY - 2016

Y1 - 2016

N2 - The expression patterns of the cannabinoid receptor type 1 (CB1R) and the cannabinoid receptor type 2 (CB2R) are well documented in rodents and primates. In vervet monkeys, CB1R is present in the retinal neurons (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells) and CB2R is exclusively found in the retinal glia (Müller cells). However, the role of these cannabinoid receptors in normal primate retinal function remains elusive. Using full-field electroretinography in adult vervet monkeys, we recorded changes in neural activity following the blockade of CB1R and CB2R by the intravitreal administration of their antagonists (AM251 and AM630, resp.) in photopic and scotopic conditions. Our results show that AM251 increases the photopic a-wave amplitude at high flash intensities, whereas AM630 increases the amplitude of both the photopic a- and b-waves. In scotopic conditions, both blockers increased the b-wave amplitude but did not change the a-wave amplitude. These findings suggest an important role of CB1R and CB2R in primate retinal function.

AB - The expression patterns of the cannabinoid receptor type 1 (CB1R) and the cannabinoid receptor type 2 (CB2R) are well documented in rodents and primates. In vervet monkeys, CB1R is present in the retinal neurons (photoreceptors, horizontal cells, bipolar cells, amacrine cells, and ganglion cells) and CB2R is exclusively found in the retinal glia (Müller cells). However, the role of these cannabinoid receptors in normal primate retinal function remains elusive. Using full-field electroretinography in adult vervet monkeys, we recorded changes in neural activity following the blockade of CB1R and CB2R by the intravitreal administration of their antagonists (AM251 and AM630, resp.) in photopic and scotopic conditions. Our results show that AM251 increases the photopic a-wave amplitude at high flash intensities, whereas AM630 increases the amplitude of both the photopic a- and b-waves. In scotopic conditions, both blockers increased the b-wave amplitude but did not change the a-wave amplitude. These findings suggest an important role of CB1R and CB2R in primate retinal function.

U2 - 10.1155/2016/1253245

DO - 10.1155/2016/1253245

M3 - Journal article

C2 - 27069692

AN - SCOPUS:84962863020

SN - 2090-5904

VL - 2016

JO - Neural Plasticity

JF - Neural Plasticity

M1 - 1253245

ER -

Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

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