Cancer risk by combined levels of YKL-40 and C-reactive protein in the general population

TY - JOUR

T1 - Cancer risk by combined levels of YKL-40 and C-reactive protein in the general population

AU - Allin, Kristine Højgaard

AU - Bojesen, S E

AU - Johansen, J S

AU - Nordestgaard, B G

PY - 2012/1/3

Y1 - 2012/1/3

N2 - Background: YKL-40 and C-reactive protein (CRP) are biomarkers that may reflect cancer-related subclinical inflammation. We assessed elevated YKL-40 and CRP levels as combined risk predictors for cancer. Methods: We measured plasma YKL-40 and CRP at baseline in 8706 individuals from the Danish general population. Results: Hazard ratio (HR) of gastrointestinal cancer for a doubling of YKL-40 levels was 1.37 (95% CI: 1.17-1.61) and indifferent to adjustment for CRP levels. Hazard ratio of lung cancer for a doubling of CRP levels was 1.35 (1.17-1.56) and indifferent to adjustment for YKL-40 levels. Compared to individuals with both low CRP (<1.7 mgl -1) and YKL-40 (<154 μgl -1), individuals with high YKL-40 but low CRP had an HR of gastrointestinal cancer of 3.36 (1.70-6.64), whereas individuals with high CRP but low YKL-40 had an HR of lung cancer of 2.19 (1.24-3.87). The area under the receiver operating characteristic (ROC) curve was 0.68 for the ability of YKL-40 to predict gastrointestinal cancer and 0.67 for the ability of CRP to predict lung cancer. Conclusion: Elevated YKL-40 levels are associated with increased risk of gastrointestinal cancer, independently of CRP levels, whereas elevated CRP levels are associated with increased risk of lung cancer, independently of YKL-40 levels.

AB - Background: YKL-40 and C-reactive protein (CRP) are biomarkers that may reflect cancer-related subclinical inflammation. We assessed elevated YKL-40 and CRP levels as combined risk predictors for cancer. Methods: We measured plasma YKL-40 and CRP at baseline in 8706 individuals from the Danish general population. Results: Hazard ratio (HR) of gastrointestinal cancer for a doubling of YKL-40 levels was 1.37 (95% CI: 1.17-1.61) and indifferent to adjustment for CRP levels. Hazard ratio of lung cancer for a doubling of CRP levels was 1.35 (1.17-1.56) and indifferent to adjustment for YKL-40 levels. Compared to individuals with both low CRP (<1.7 mgl -1) and YKL-40 (<154 μgl -1), individuals with high YKL-40 but low CRP had an HR of gastrointestinal cancer of 3.36 (1.70-6.64), whereas individuals with high CRP but low YKL-40 had an HR of lung cancer of 2.19 (1.24-3.87). The area under the receiver operating characteristic (ROC) curve was 0.68 for the ability of YKL-40 to predict gastrointestinal cancer and 0.67 for the ability of CRP to predict lung cancer. Conclusion: Elevated YKL-40 levels are associated with increased risk of gastrointestinal cancer, independently of CRP levels, whereas elevated CRP levels are associated with increased risk of lung cancer, independently of YKL-40 levels.

KW - Adipokines

KW - Aged

KW - C-Reactive Protein

KW - Denmark

KW - Female

KW - Humans

KW - Lectins

KW - Male

KW - Middle Aged

KW - Neoplasms

KW - Prospective Studies

KW - Risk Factors

U2 - 10.1038/bjc.2011.501

DO - 10.1038/bjc.2011.501

M3 - Journal article

C2 - 22095223

SN - 0007-0920

VL - 106

SP - 199

EP - 205

JO - B J C

JF - B J C

IS - 1

ER -