Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health

L Hagmar; S Bonassi; U Strömberg; Z Mikoczy; C Lando; I L Hansteen; A H Montagud; Lisbeth E. Knudsen; H Norppa; C Reuterwall; H Tinnerberg; A Brogger; A Forni; B Högstedt; B Lambert; F Mitelman; I Nordenson; S Salomaa; S Skerfving

Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health

L Hagmar, S Bonassi, U Strömberg, Z Mikoczy, C Lando, I L Hansteen, A H Montagud, Lisbeth E. Knudsen, H Norppa, C Reuterwall, H Tinnerberg, A Brogger, A Forni, B Högstedt, B Lambert, F Mitelman, I Nordenson, S Salomaa, S Skerfving

Section of Environmental Health

98 Citations (Scopus)

Abstract

The cytogenetic endpoints in peripheral blood lymphocytes: chromosomal aberrations (CA), sister chromatid exchange (SCE) and micronuclei (MN) are established biomarkers of exposure for mutagens or carcinogens in the work environment. However, it is not clear whether these biomarkers also may serve as biomarkers for genotoxic effects which will result in an enhanced cancer risk. In order to assess this problem, Nordic and Italian cohorts were established, and preliminary results from these two studies indicated a predictive value of CA frequency for cancer risk, whereas no such associations were observed for SCE or MN. A collaborative study between the Nordic and Italian research groups, will enable a more thorough evaluation of the cancer predictivity of the cytogenetic endpoints. We here report on the establishment of a joint data base comprising 5271 subjects, examined 1965-1988 for at least one cytogenetic biomarker. Totally, 3540 subjects had been examined for CA, 2702 for SCE and 1496 for MN. These cohorts have been followed-up with respect to subsequent cancer mortality or cancer incidence, and the expected values have been calculated from rates derived from the general populations in each country. Stratified cohort analyses will be performed with respect to the levels of the cytogenetic biomarkers. The importance of potential effect modifiers such as gender, age at test, and time since test, will be evaluated using Poisson regression models. The remaining two potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.

Original language	English
Journal	Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume	405
Issue number	2
Pages (from-to)	171-8
Number of pages	7
ISSN	0027-5107
Publication status	Published - 1998

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Hagmar, L., Bonassi, S., Strömberg, U., Mikoczy, Z., Lando, C., Hansteen, I. L., Montagud, A. H., Knudsen, L. E., Norppa, H., Reuterwall, C., Tinnerberg, H., Brogger, A., Forni, A., Högstedt, B., Lambert, B., Mitelman, F., Nordenson, I., Salomaa, S., & Skerfving, S. (1998). Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 405(2), 171-8.

Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health. / Hagmar, L; Bonassi, S; Strömberg, U et al.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 405, No. 2, 1998, p. 171-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Hagmar, L, Bonassi, S, Strömberg, U, Mikoczy, Z, Lando, C, Hansteen, IL, Montagud, AH, Knudsen, LE, Norppa, H, Reuterwall, C, Tinnerberg, H, Brogger, A, Forni, A, Högstedt, B, Lambert, B, Mitelman, F, Nordenson, I, Salomaa, S & Skerfving, S 1998, 'Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, vol. 405, no. 2, pp. 171-8.

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title = "Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health",

abstract = "The cytogenetic endpoints in peripheral blood lymphocytes: chromosomal aberrations (CA), sister chromatid exchange (SCE) and micronuclei (MN) are established biomarkers of exposure for mutagens or carcinogens in the work environment. However, it is not clear whether these biomarkers also may serve as biomarkers for genotoxic effects which will result in an enhanced cancer risk. In order to assess this problem, Nordic and Italian cohorts were established, and preliminary results from these two studies indicated a predictive value of CA frequency for cancer risk, whereas no such associations were observed for SCE or MN. A collaborative study between the Nordic and Italian research groups, will enable a more thorough evaluation of the cancer predictivity of the cytogenetic endpoints. We here report on the establishment of a joint data base comprising 5271 subjects, examined 1965-1988 for at least one cytogenetic biomarker. Totally, 3540 subjects had been examined for CA, 2702 for SCE and 1496 for MN. These cohorts have been followed-up with respect to subsequent cancer mortality or cancer incidence, and the expected values have been calculated from rates derived from the general populations in each country. Stratified cohort analyses will be performed with respect to the levels of the cytogenetic biomarkers. The importance of potential effect modifiers such as gender, age at test, and time since test, will be evaluated using Poisson regression models. The remaining two potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.",

author = "L Hagmar and S Bonassi and U Str{\"o}mberg and Z Mikoczy and C Lando and Hansteen, {I L} and Montagud, {A H} and Knudsen, {Lisbeth E.} and H Norppa and C Reuterwall and H Tinnerberg and A Brogger and A Forni and B H{\"o}gstedt and B Lambert and F Mitelman and I Nordenson and S Salomaa and S Skerfving",

note = "Keywords: Chromosome Aberrations; Cohort Studies; Databases, Factual; Europe; Female; Follow-Up Studies; Humans; Incidence; Male; Micronuclei, Chromosome-Defective; Neoplasms; Occupational Health; Population Surveillance; Predictive Value of Tests; Risk Factors; Sister Chromatid Exchange; Tumor Markers, Biological",

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T1 - Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health

AU - Hagmar, L

AU - Bonassi, S

AU - Strömberg, U

AU - Mikoczy, Z

AU - Lando, C

AU - Hansteen, I L

AU - Montagud, A H

AU - Knudsen, Lisbeth E.

AU - Norppa, H

AU - Reuterwall, C

AU - Tinnerberg, H

AU - Brogger, A

AU - Forni, A

AU - Högstedt, B

AU - Lambert, B

AU - Mitelman, F

AU - Nordenson, I

AU - Salomaa, S

AU - Skerfving, S

N1 - Keywords: Chromosome Aberrations; Cohort Studies; Databases, Factual; Europe; Female; Follow-Up Studies; Humans; Incidence; Male; Micronuclei, Chromosome-Defective; Neoplasms; Occupational Health; Population Surveillance; Predictive Value of Tests; Risk Factors; Sister Chromatid Exchange; Tumor Markers, Biological

PY - 1998

Y1 - 1998

N2 - The cytogenetic endpoints in peripheral blood lymphocytes: chromosomal aberrations (CA), sister chromatid exchange (SCE) and micronuclei (MN) are established biomarkers of exposure for mutagens or carcinogens in the work environment. However, it is not clear whether these biomarkers also may serve as biomarkers for genotoxic effects which will result in an enhanced cancer risk. In order to assess this problem, Nordic and Italian cohorts were established, and preliminary results from these two studies indicated a predictive value of CA frequency for cancer risk, whereas no such associations were observed for SCE or MN. A collaborative study between the Nordic and Italian research groups, will enable a more thorough evaluation of the cancer predictivity of the cytogenetic endpoints. We here report on the establishment of a joint data base comprising 5271 subjects, examined 1965-1988 for at least one cytogenetic biomarker. Totally, 3540 subjects had been examined for CA, 2702 for SCE and 1496 for MN. These cohorts have been followed-up with respect to subsequent cancer mortality or cancer incidence, and the expected values have been calculated from rates derived from the general populations in each country. Stratified cohort analyses will be performed with respect to the levels of the cytogenetic biomarkers. The importance of potential effect modifiers such as gender, age at test, and time since test, will be evaluated using Poisson regression models. The remaining two potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.

AB - The cytogenetic endpoints in peripheral blood lymphocytes: chromosomal aberrations (CA), sister chromatid exchange (SCE) and micronuclei (MN) are established biomarkers of exposure for mutagens or carcinogens in the work environment. However, it is not clear whether these biomarkers also may serve as biomarkers for genotoxic effects which will result in an enhanced cancer risk. In order to assess this problem, Nordic and Italian cohorts were established, and preliminary results from these two studies indicated a predictive value of CA frequency for cancer risk, whereas no such associations were observed for SCE or MN. A collaborative study between the Nordic and Italian research groups, will enable a more thorough evaluation of the cancer predictivity of the cytogenetic endpoints. We here report on the establishment of a joint data base comprising 5271 subjects, examined 1965-1988 for at least one cytogenetic biomarker. Totally, 3540 subjects had been examined for CA, 2702 for SCE and 1496 for MN. These cohorts have been followed-up with respect to subsequent cancer mortality or cancer incidence, and the expected values have been calculated from rates derived from the general populations in each country. Stratified cohort analyses will be performed with respect to the levels of the cytogenetic biomarkers. The importance of potential effect modifiers such as gender, age at test, and time since test, will be evaluated using Poisson regression models. The remaining two potential effect modifiers, occupational exposures and smoking, will be assessed in a case-referent study within the study base.

M3 - Journal article

C2 - 9748557

SN - 0027-5107

VL - 405

SP - 171

EP - 178

JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

IS - 2

ER -

Cancer predictive value of cytogenetic markers used in occupational health surveillance programs: a report from an ongoing study by the European Study Group on Cytogenetic Biomarkers and Health

Abstract

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