Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study

Konstantinos H Katsanos; Athina Tatsioni; Natalia Pedersen; Mary Shuhaibar; Vicent Hernandez Ramirez; Patrizia Politi; Evelien Rombrechts; Marieke Pierik; Juan Clofent; Marina Beltrami; Paolo Bodini; Joao Freitas; Ioannis Mouzas; Giovanni Fornaciari; Bjorn Moum; Peter Laszlo Lakatos; Severine Vermeire; Ebbe Langholz; Selwyn Odes; Colm O' Morain; Reinhold Stockbrügger; Pia Munkholm; Epameinondas V Tsianos

doi:10.1016/j.crohns.2011.04.013

Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study

Konstantinos H Katsanos, Athina Tatsioni, Natalia Pedersen, Mary Shuhaibar, Vicent Hernandez Ramirez, Patrizia Politi, Evelien Rombrechts, Marieke Pierik, Juan Clofent, Marina Beltrami, Paolo Bodini, Joao Freitas, Ioannis Mouzas, Giovanni Fornaciari, Bjorn Moum, Peter Laszlo Lakatos, Severine Vermeire, Ebbe Langholz, Selwyn Odes, Colm O' MorainReinhold Stockbrügger, Pia Munkholm, Epameinondas V Tsianos

35 Citations (Scopus)

Abstract

AIM OF THE STUDY: To determine the occurrence of intestinal and extraintestinal cancers in the 1993-2009 prospective European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort.

PATIENTS-METHODS: A physician per patient form was completed for 681 inflammatory bowel disease patients (445UC/236CD) from 9 centers (7 countries) derived from the original EC-IBD cohort. For the 15-year follow up period, rates of detection of intestinal and extraintestinal cancers were computed.

RESULTS: Patient follow-up time was fifteen years. In total 62/681 patients (9.1%) [41 with ulcerative colitis/21 with Crohn's disease, 36 males/26 females] were diagnosed with sixty-six cancers (four patients with double cancers). Colorectal cancer was diagnosed in 9/681 patients [1.3%] (1 Crohn's disease and 8 ulcerative colitis). The remaining 53 cancers were extraintestinal. There was a higher prevalence of intestinal cancer in the Northern centers compared to Southern centers [p=NS]. Southern centers had more cases of extraintestinal cancer compared to Northern centers [p=NS]. The frequency of all observed types of cancers in Northern and in Southern centers did not differ compared to the expected one in the background population.

CONCLUSIONS: In the fifteen-year follow up of the EC-IBD Study Group cohort the prevalence of cancer was 9.1% with most patients having a single neoplasm and an extraintestinal neoplasm. In Northern centers there were more intestinal cancers while in Southern centers there were more extraintestinal cancers compared to Northern centers. In this IBD cohort the frequency of observed cancers was not different from that expected in the background population.

Original language	English
Journal	Journal of Crohn's & colitis
Volume	5
Issue number	5
Pages (from-to)	430-42
Number of pages	13
ISSN	1873-9946
DOIs	https://doi.org/10.1016/j.crohns.2011.04.013
Publication status	Published - Oct 2011

Keywords

Colorectal Neoplasms/epidemiology
Europe/epidemiology
Female
Follow-Up Studies
Humans
Inflammatory Bowel Diseases/complications
Male
Neoplasms/epidemiology
Prevalence

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Katsanos, K. H., Tatsioni, A., Pedersen, N., Shuhaibar, M., Ramirez, V. H., Politi, P., Rombrechts, E., Pierik, M., Clofent, J., Beltrami, M., Bodini, P., Freitas, J., Mouzas, I., Fornaciari, G., Moum, B., Lakatos, P. L., Vermeire, S., Langholz, E., Odes, S., ... Tsianos, E. V. (2011). Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study. Journal of Crohn's & colitis, 5(5), 430-42. https://doi.org/10.1016/j.crohns.2011.04.013

Katsanos, KH, Tatsioni, A, Pedersen, N, Shuhaibar, M, Ramirez, VH, Politi, P, Rombrechts, E, Pierik, M, Clofent, J, Beltrami, M, Bodini, P, Freitas, J, Mouzas, I, Fornaciari, G, Moum, B, Lakatos, PL, Vermeire, S, Langholz, E, Odes, S, Morain, CO, Stockbrügger, R, Munkholm, P & Tsianos, EV 2011, 'Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study', Journal of Crohn's & colitis, vol. 5, no. 5, pp. 430-42. https://doi.org/10.1016/j.crohns.2011.04.013

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title = "Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study",

abstract = "AIM OF THE STUDY: To determine the occurrence of intestinal and extraintestinal cancers in the 1993-2009 prospective European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort.PATIENTS-METHODS: A physician per patient form was completed for 681 inflammatory bowel disease patients (445UC/236CD) from 9 centers (7 countries) derived from the original EC-IBD cohort. For the 15-year follow up period, rates of detection of intestinal and extraintestinal cancers were computed.RESULTS: Patient follow-up time was fifteen years. In total 62/681 patients (9.1%) [41 with ulcerative colitis/21 with Crohn's disease, 36 males/26 females] were diagnosed with sixty-six cancers (four patients with double cancers). Colorectal cancer was diagnosed in 9/681 patients [1.3%] (1 Crohn's disease and 8 ulcerative colitis). The remaining 53 cancers were extraintestinal. There was a higher prevalence of intestinal cancer in the Northern centers compared to Southern centers [p=NS]. Southern centers had more cases of extraintestinal cancer compared to Northern centers [p=NS]. The frequency of all observed types of cancers in Northern and in Southern centers did not differ compared to the expected one in the background population.CONCLUSIONS: In the fifteen-year follow up of the EC-IBD Study Group cohort the prevalence of cancer was 9.1% with most patients having a single neoplasm and an extraintestinal neoplasm. In Northern centers there were more intestinal cancers while in Southern centers there were more extraintestinal cancers compared to Northern centers. In this IBD cohort the frequency of observed cancers was not different from that expected in the background population.",

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author = "Katsanos, {Konstantinos H} and Athina Tatsioni and Natalia Pedersen and Mary Shuhaibar and Ramirez, {Vicent Hernandez} and Patrizia Politi and Evelien Rombrechts and Marieke Pierik and Juan Clofent and Marina Beltrami and Paolo Bodini and Joao Freitas and Ioannis Mouzas and Giovanni Fornaciari and Bjorn Moum and Lakatos, {Peter Laszlo} and Severine Vermeire and Ebbe Langholz and Selwyn Odes and Morain, {Colm O'} and Reinhold Stockbr{\"u}gger and Pia Munkholm and Tsianos, {Epameinondas V}",

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doi = "10.1016/j.crohns.2011.04.013",

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T1 - Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study

AU - Katsanos, Konstantinos H

AU - Tatsioni, Athina

AU - Pedersen, Natalia

AU - Shuhaibar, Mary

AU - Ramirez, Vicent Hernandez

AU - Politi, Patrizia

AU - Rombrechts, Evelien

AU - Pierik, Marieke

AU - Clofent, Juan

AU - Beltrami, Marina

AU - Bodini, Paolo

AU - Freitas, Joao

AU - Mouzas, Ioannis

AU - Fornaciari, Giovanni

AU - Moum, Bjorn

AU - Lakatos, Peter Laszlo

AU - Vermeire, Severine

AU - Langholz, Ebbe

AU - Odes, Selwyn

AU - Morain, Colm O'

AU - Stockbrügger, Reinhold

AU - Munkholm, Pia

AU - Tsianos, Epameinondas V

PY - 2011/10

Y1 - 2011/10

N2 - AIM OF THE STUDY: To determine the occurrence of intestinal and extraintestinal cancers in the 1993-2009 prospective European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort.PATIENTS-METHODS: A physician per patient form was completed for 681 inflammatory bowel disease patients (445UC/236CD) from 9 centers (7 countries) derived from the original EC-IBD cohort. For the 15-year follow up period, rates of detection of intestinal and extraintestinal cancers were computed.RESULTS: Patient follow-up time was fifteen years. In total 62/681 patients (9.1%) [41 with ulcerative colitis/21 with Crohn's disease, 36 males/26 females] were diagnosed with sixty-six cancers (four patients with double cancers). Colorectal cancer was diagnosed in 9/681 patients [1.3%] (1 Crohn's disease and 8 ulcerative colitis). The remaining 53 cancers were extraintestinal. There was a higher prevalence of intestinal cancer in the Northern centers compared to Southern centers [p=NS]. Southern centers had more cases of extraintestinal cancer compared to Northern centers [p=NS]. The frequency of all observed types of cancers in Northern and in Southern centers did not differ compared to the expected one in the background population.CONCLUSIONS: In the fifteen-year follow up of the EC-IBD Study Group cohort the prevalence of cancer was 9.1% with most patients having a single neoplasm and an extraintestinal neoplasm. In Northern centers there were more intestinal cancers while in Southern centers there were more extraintestinal cancers compared to Northern centers. In this IBD cohort the frequency of observed cancers was not different from that expected in the background population.

AB - AIM OF THE STUDY: To determine the occurrence of intestinal and extraintestinal cancers in the 1993-2009 prospective European Collaborative Inflammatory Bowel Disease (EC-IBD) Study Group cohort.PATIENTS-METHODS: A physician per patient form was completed for 681 inflammatory bowel disease patients (445UC/236CD) from 9 centers (7 countries) derived from the original EC-IBD cohort. For the 15-year follow up period, rates of detection of intestinal and extraintestinal cancers were computed.RESULTS: Patient follow-up time was fifteen years. In total 62/681 patients (9.1%) [41 with ulcerative colitis/21 with Crohn's disease, 36 males/26 females] were diagnosed with sixty-six cancers (four patients with double cancers). Colorectal cancer was diagnosed in 9/681 patients [1.3%] (1 Crohn's disease and 8 ulcerative colitis). The remaining 53 cancers were extraintestinal. There was a higher prevalence of intestinal cancer in the Northern centers compared to Southern centers [p=NS]. Southern centers had more cases of extraintestinal cancer compared to Northern centers [p=NS]. The frequency of all observed types of cancers in Northern and in Southern centers did not differ compared to the expected one in the background population.CONCLUSIONS: In the fifteen-year follow up of the EC-IBD Study Group cohort the prevalence of cancer was 9.1% with most patients having a single neoplasm and an extraintestinal neoplasm. In Northern centers there were more intestinal cancers while in Southern centers there were more extraintestinal cancers compared to Northern centers. In this IBD cohort the frequency of observed cancers was not different from that expected in the background population.

KW - Colorectal Neoplasms/epidemiology

KW - Europe/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Inflammatory Bowel Diseases/complications

KW - Male

KW - Neoplasms/epidemiology

KW - Prevalence

U2 - 10.1016/j.crohns.2011.04.013

DO - 10.1016/j.crohns.2011.04.013

M3 - Journal article

C2 - 21939917

SN - 1873-9946

VL - 5

SP - 430

EP - 442

JO - Journal of Crohn's & colitis

JF - Journal of Crohn's & colitis

IS - 5

ER -

Cancer in inflammatory bowel disease 15 years after diagnosis in a population-based European Collaborative follow-up study

Abstract

Keywords

UN SDGs

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