Can ambulatory blood pressure measurements substitute assessment of subclinical cardiovascular damage?

TY - JOUR

T1 - Can ambulatory blood pressure measurements substitute assessment of subclinical cardiovascular damage?

AU - Sehestedt, Thomas

AU - Jeppesen, Jørgen

AU - Hansen, Tine W

AU - Rasmussen, Susanne

AU - Wachtell, Kristian

AU - Ibsen, Hans

AU - Torp-Pedersen, Christian

AU - Olsen, Michael H

PY - 2012/3

Y1 - 2012/3

N2 - OBJECTIVE:: We have previously demonstrated that markers of subclinical organ damage (SOD) improve cardiovascular risk prediction in healthy individuals. We wanted to investigate whether this additive effect of SOD was due to inaccurate blood pressure (BP) measurement or whether ambulatory BP (AMBP) added further to risk prediction. METHODS:: In a population cohort of 1385 Danish individuals free of cardiovascular disease and diabetes, we recorded traditional risk factors, AMBP and pulse wave velocity (PWV), urine albumin/creatinine ratio (UACR), left ventricular mass index (LVMI) and carotid atherosclerotic plaques at baseline. A composite cardiovascular endpoint (CEP) consisting of cardiovascular death and nonfatal myocardial infarction and stroke was recorded in national registries. RESULTS:: During a median follow-up of 12.8 years, a total of 119 CEPs occurred. In categorical analysis, presence of SOD as well as masked hypertension increased sensitivity of Systemic Coronary Risk Estimation from 73.9 to 89.1% (P¿

AB - OBJECTIVE:: We have previously demonstrated that markers of subclinical organ damage (SOD) improve cardiovascular risk prediction in healthy individuals. We wanted to investigate whether this additive effect of SOD was due to inaccurate blood pressure (BP) measurement or whether ambulatory BP (AMBP) added further to risk prediction. METHODS:: In a population cohort of 1385 Danish individuals free of cardiovascular disease and diabetes, we recorded traditional risk factors, AMBP and pulse wave velocity (PWV), urine albumin/creatinine ratio (UACR), left ventricular mass index (LVMI) and carotid atherosclerotic plaques at baseline. A composite cardiovascular endpoint (CEP) consisting of cardiovascular death and nonfatal myocardial infarction and stroke was recorded in national registries. RESULTS:: During a median follow-up of 12.8 years, a total of 119 CEPs occurred. In categorical analysis, presence of SOD as well as masked hypertension increased sensitivity of Systemic Coronary Risk Estimation from 73.9 to 89.1% (P¿

U2 - 10.1097/hjh.0b013e32834f6f60

DO - 10.1097/hjh.0b013e32834f6f60

M3 - Journal article

C2 - 22241138

SN - 0263-6352

VL - 30

SP - 513

EP - 521

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 3

ER -