Calcium and vitamin D3 supplements in calcium and vitamin D3 sufficient early postmenopausal healthy women

TY - JOUR

T1 - Calcium and vitamin D3 supplements in calcium and vitamin D3 sufficient early postmenopausal healthy women

AU - Tfelt-Hansen, J.

AU - Tørring, Ove

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Objective: To study the calcium homeostasis in healthy, calcium and vitamin D replete early postmenopausal women during oral supplementation with calcium and vitamin D3. Design: A prospective, placebo-controlled, randomised, double-single-blind, 3-week study. Setting: Outpatient clinic at Copenhagen University Hospital, Denmark. Subjects: In all, 17 started, one was excluded. Totally, 16 healthy women, 45-61 y of age (mean 57.3 y) who were at least 4 y after menopause (mean 6.7 y) completed. Interventions: All underwent three consecutive 7-day study periods. Each began with 4 days of normal diet followed by 3 days treatment of either C: one tablet of 1.250 mg calcium carbonate (ie 500 mg Ca2+ per tablet) twice daily (breakfast and dinner), or CD3: as in C but plus 400 IU vitamin D3 b.i.d., or P (only) placebo tablets b.i.d. Results: At baseline plasma 25-hydroxycholecalciferol was normal (66±22 nmol/l) and the calcium intake without supplements 850 mg/day. In group C, the 24-h urinary calcium increased by 35% (6.9±2.0 mmol), vs the placebo group P (5.1±1.6 mmol) (P<0.05). Addition of 800 IU vitamin D3 daily (CD3) did not increase calcium excretion further (6.6±2.1 mmol) but decreased plasma 1,25-(OH 2-vitamin D3 by 21% (P<0.05). Conclusions: In this carefully controlled study calcium plus vitamin D3 supplements only had minor influences of uncertain significance on the calcium balance in healthy, calcium and vitamin D sufficient early postmenopausal women.

AB - Objective: To study the calcium homeostasis in healthy, calcium and vitamin D replete early postmenopausal women during oral supplementation with calcium and vitamin D3. Design: A prospective, placebo-controlled, randomised, double-single-blind, 3-week study. Setting: Outpatient clinic at Copenhagen University Hospital, Denmark. Subjects: In all, 17 started, one was excluded. Totally, 16 healthy women, 45-61 y of age (mean 57.3 y) who were at least 4 y after menopause (mean 6.7 y) completed. Interventions: All underwent three consecutive 7-day study periods. Each began with 4 days of normal diet followed by 3 days treatment of either C: one tablet of 1.250 mg calcium carbonate (ie 500 mg Ca2+ per tablet) twice daily (breakfast and dinner), or CD3: as in C but plus 400 IU vitamin D3 b.i.d., or P (only) placebo tablets b.i.d. Results: At baseline plasma 25-hydroxycholecalciferol was normal (66±22 nmol/l) and the calcium intake without supplements 850 mg/day. In group C, the 24-h urinary calcium increased by 35% (6.9±2.0 mmol), vs the placebo group P (5.1±1.6 mmol) (P<0.05). Addition of 800 IU vitamin D3 daily (CD3) did not increase calcium excretion further (6.6±2.1 mmol) but decreased plasma 1,25-(OH 2-vitamin D3 by 21% (P<0.05). Conclusions: In this carefully controlled study calcium plus vitamin D3 supplements only had minor influences of uncertain significance on the calcium balance in healthy, calcium and vitamin D sufficient early postmenopausal women.

KW - 1,25(OH)D

KW - Ca

KW - Calcium metabolism

KW - Cholecalciferol

KW - Postmenopausal women

KW - PTH

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=5744230835&partnerID=8YFLogxK

U2 - 10.1038/sj.ejcn.1601987

DO - 10.1038/sj.ejcn.1601987

M3 - Journal article

C2 - 15114377

AN - SCOPUS:5744230835

SN - 0954-3007

VL - 58

SP - 1420

EP - 1424

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 10

ER -