Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men

Alessandro Andreucci; Emina Mocevic; Bo A G Jönsson; Aleksander Giwercman; Yvonne Lundberg Giwercman; Gunnar Toft; Thomas Lundh; Davide Bizzaro; Ina Olmer Specht; Jens Peter Bonde

doi:10.1016/j.reprotox.2015.01.010

Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men

Alessandro Andreucci, Emina Mocevic, Bo A G Jönsson, Aleksander Giwercman, Yvonne Lundberg Giwercman, Gunnar Toft, Thomas Lundh, Davide Bizzaro, Ina Olmer Specht, Jens Peter Bonde

7 Citations (Scopus)

Abstract

We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.

Original language	English
Journal	Reproductive Toxicology
Volume	53
Pages (from-to)	33-8
Number of pages	6
ISSN	0890-6238
DOIs	https://doi.org/10.1016/j.reprotox.2015.01.010
Publication status	Published - 1 Jun 2015

Keywords

Adolescent
Adult
Cadmium
Cross-Sectional Studies
Greenland
Humans
Inuits
Male
Middle Aged
Poland
Polymorphism, Genetic
Prostate
Prostate-Specific Antigen
Receptors, Androgen
Semen
Ukraine
Young Adult
Zinc

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10.1016/j.reprotox.2015.01.010

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Andreucci, A., Mocevic, E., Jönsson, B. A. G., Giwercman, A., Giwercman, Y. L., Toft, G., Lundh, T., Bizzaro, D., Specht, I. O., & Bonde, J. P. (2015). Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men. Reproductive Toxicology, 53, 33-8. https://doi.org/10.1016/j.reprotox.2015.01.010

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title = "Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men",

abstract = "We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.",

keywords = "Adolescent, Adult, Cadmium, Cross-Sectional Studies, Greenland, Humans, Inuits, Male, Middle Aged, Poland, Polymorphism, Genetic, Prostate, Prostate-Specific Antigen, Receptors, Androgen, Semen, Ukraine, Young Adult, Zinc",

author = "Alessandro Andreucci and Emina Mocevic and J{\"o}nsson, {Bo A G} and Aleksander Giwercman and Giwercman, {Yvonne Lundberg} and Gunnar Toft and Thomas Lundh and Davide Bizzaro and Specht, {Ina Olmer} and Bonde, {Jens Peter}",

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year = "2015",

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day = "1",

doi = "10.1016/j.reprotox.2015.01.010",

language = "English",

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T1 - Cadmium may impair prostate function as measured by prostate specific antigen in semen

T2 - A cross-sectional study among European and Inuit men

AU - Andreucci, Alessandro

AU - Mocevic, Emina

AU - Jönsson, Bo A G

AU - Giwercman, Aleksander

AU - Giwercman, Yvonne Lundberg

AU - Toft, Gunnar

AU - Lundh, Thomas

AU - Bizzaro, Davide

AU - Specht, Ina Olmer

AU - Bonde, Jens Peter

PY - 2015/6/1

Y1 - 2015/6/1

N2 - We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.

AB - We investigated the association between cadmium in blood and the concentration of the prostate specific antigen (PSA) in semen, including the modifying effects of zinc or the CAG polymorphism in the androgen receptor (AR). Blood and semen samples were collected from 504 partners of pregnant women in Greenland, Poland and Ukraine. We found an inverse trend between cadmium and PSA (log(β) = -0.121, 95% confidence interval (CI): -0.213; -0.029, P = 0.0103) in Greenlandic men. Similar results were observed in men with a high number of CAG repeats (CAG 24) (log(β) = -0.231, 95% CI: -0.363; -0.098, P = 0.0009). Inverse trends between cadmium and PSA were found when semen zinc concentrations were below the median value for men from Ukraine and Greenland. These outcomes suggest that cadmium may impair prostate function, as measured by PSA in semen, while high zinc levels and a low number of CAG repeats protects against this action.

KW - Adolescent

KW - Adult

KW - Cadmium

KW - Cross-Sectional Studies

KW - Greenland

KW - Humans

KW - Inuits

KW - Male

KW - Middle Aged

KW - Poland

KW - Polymorphism, Genetic

KW - Prostate

KW - Prostate-Specific Antigen

KW - Receptors, Androgen

KW - Semen

KW - Ukraine

KW - Young Adult

KW - Zinc

U2 - 10.1016/j.reprotox.2015.01.010

DO - 10.1016/j.reprotox.2015.01.010

M3 - Journal article

C2 - 25660730

SN - 0890-6238

VL - 53

SP - 33

EP - 38

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Cadmium may impair prostate function as measured by prostate specific antigen in semen: A cross-sectional study among European and Inuit men

Abstract

Keywords

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