C-reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease

Jeppe Zacho; Anne Tybjaerg-Hansen; Børge Grønne Nordestgaard

doi:10.1080/00365510903056015

C-reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease

Jeppe Zacho, Anne Tybjaerg-Hansen, Børge Grønne Nordestgaard

8 Citations (Scopus)

Abstract

We tested whether genetically elevated levels of C-reactive protein (CRP) cause increased risk of ischemic heart disease and ischemic cerebrovascular disease. Levels of CRP >3mg/L, compared with levels <1mg/L, associated with a 1.6- and 1.3-fold increased risk of ischemic heart disease and ischemic cerebrovascular disease. Genotype combinations of the 4 CRP polymorphisms associated with up to a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations did not associate with increased risk of ischemic heart and cerebrovascular disease.

Original language	English
Journal	Scandinavian Journal of Clinical & Laboratory Investigation
Volume	69
Issue number	4
Pages (from-to)	442-6
Number of pages	5
ISSN	0036-5513
DOIs	https://doi.org/10.1080/00365510903056015
Publication status	Published - 2009

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10.1080/00365510903056015

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title = "C-reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease",

abstract = "We tested whether genetically elevated levels of C-reactive protein (CRP) cause increased risk of ischemic heart disease and ischemic cerebrovascular disease. Levels of CRP >3mg/L, compared with levels <1mg/L, associated with a 1.6- and 1.3-fold increased risk of ischemic heart disease and ischemic cerebrovascular disease. Genotype combinations of the 4 CRP polymorphisms associated with up to a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations did not associate with increased risk of ischemic heart and cerebrovascular disease.",

author = "Jeppe Zacho and Anne Tybjaerg-Hansen and Nordestgaard, {B{\o}rge Gr{\o}nne}",

note = "Keywords: C-Reactive Protein; Cerebrovascular Disorders; Humans; Myocardial Ischemia; Risk Factors",

year = "2009",

doi = "10.1080/00365510903056015",

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T1 - C-reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease

AU - Zacho, Jeppe

AU - Tybjaerg-Hansen, Anne

AU - Nordestgaard, Børge Grønne

N1 - Keywords: C-Reactive Protein; Cerebrovascular Disorders; Humans; Myocardial Ischemia; Risk Factors

PY - 2009

Y1 - 2009

N2 - We tested whether genetically elevated levels of C-reactive protein (CRP) cause increased risk of ischemic heart disease and ischemic cerebrovascular disease. Levels of CRP >3mg/L, compared with levels <1mg/L, associated with a 1.6- and 1.3-fold increased risk of ischemic heart disease and ischemic cerebrovascular disease. Genotype combinations of the 4 CRP polymorphisms associated with up to a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations did not associate with increased risk of ischemic heart and cerebrovascular disease.

AB - We tested whether genetically elevated levels of C-reactive protein (CRP) cause increased risk of ischemic heart disease and ischemic cerebrovascular disease. Levels of CRP >3mg/L, compared with levels <1mg/L, associated with a 1.6- and 1.3-fold increased risk of ischemic heart disease and ischemic cerebrovascular disease. Genotype combinations of the 4 CRP polymorphisms associated with up to a 64% increase in CRP levels, resulting in a theoretically predicted increased risk of up to 32% for ischemic heart disease and up to 25% for ischemic cerebrovascular disease. However, these genotype combinations did not associate with increased risk of ischemic heart and cerebrovascular disease.

U2 - 10.1080/00365510903056015

DO - 10.1080/00365510903056015

M3 - Journal article

C2 - 19533498

SN - 0036-5513

VL - 69

SP - 442

EP - 446

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

IS - 4

ER -

C-reactive protein, genetically elevated levels and risk of ischemic heart and cerebrovascular disease

Abstract

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