TY - JOUR
T1 - Bulk characterization of pharmaceutical powders by low-pressure compression II
T2 - effect of method settings and particle size
AU - Hagsten Sørensen, A.
AU - Sonnergaard, Jørn
AU - Hovgaard, L.
PY - 2006/5/1
Y1 - 2006/5/1
N2 - The aim of the present study was to investigate the effect of punch and die diameter, sample size, compression speed, and particle size on two low-pressure compression-derived parameters; the compressed density and the Walker w parameter. The excellent repeatability of the low-pressure compression method allowed small effects of variations in punch and die diameter and sample size to be demonstrated on a high significance level. Changing the compression speed, however, did not cause a significant effect in the compressed density, whereas a decrease in w was seen. The effect of particle size was studied by compressing and tapping different grades of calcium carbonate, lactose, and microcrystalline cellulose. The low-pressure compression-derived parameters were compared to tapped densities and to Compressibility Indexes obtained by tapping volumetry. Even though the relationship between particle size and the low-pressure compression-derived parameters appeared to be more complicated, a similar trend was observed. It was concluded that the low-pressure compression method provides a useful alternative to the more sample-consuming methods providing flow-related information.
AB - The aim of the present study was to investigate the effect of punch and die diameter, sample size, compression speed, and particle size on two low-pressure compression-derived parameters; the compressed density and the Walker w parameter. The excellent repeatability of the low-pressure compression method allowed small effects of variations in punch and die diameter and sample size to be demonstrated on a high significance level. Changing the compression speed, however, did not cause a significant effect in the compressed density, whereas a decrease in w was seen. The effect of particle size was studied by compressing and tapping different grades of calcium carbonate, lactose, and microcrystalline cellulose. The low-pressure compression-derived parameters were compared to tapped densities and to Compressibility Indexes obtained by tapping volumetry. Even though the relationship between particle size and the low-pressure compression-derived parameters appeared to be more complicated, a similar trend was observed. It was concluded that the low-pressure compression method provides a useful alternative to the more sample-consuming methods providing flow-related information.
UR - http://www.scopus.com/inward/record.url?scp=33745071563&partnerID=8YFLogxK
U2 - 10.1080/10837450600561448
DO - 10.1080/10837450600561448
M3 - Journal article
AN - SCOPUS:33745071563
SN - 1083-7450
VL - 11
SP - 235
EP - 241
JO - Pharmaceutical Development and Technology
JF - Pharmaceutical Development and Technology
IS - 2
ER -