Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

Gregory W. Severin; Carsten H. Nielsen; Andreas I. Jensen; Jesper Fonslet; Andreas Kjær; Fedor Zhuravlev

doi:10.1021/acs.jmedchem.5b01167

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic)

Gregory W. Severin, Carsten H. Nielsen, Andreas I. Jensen, Jesper Fonslet, Andreas Kjær, Fedor Zhuravlev

14 Citations (Scopus)

Abstract

We present a novel solid-phase based ⁴⁵Ti radiolabeling methodology and the implementation of ⁴⁵Ti-PET in titanium-based antineoplastics using the showcase compound [⁴⁵Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

Original language	English
Journal	Journal of Medicinal Chemistry
Volume	58
Issue number	18
Pages (from-to)	7591-7595
Number of pages	5
ISSN	0022-2623
DOIs	https://doi.org/10.1021/acs.jmedchem.5b01167
Publication status	Published - 24 Sept 2015

Access to Document

10.1021/acs.jmedchem.5b01167

Cite this

Bringing Radiotracing to Titanium-Based Antineoplastics : Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic). / Severin, Gregory W.; Nielsen, Carsten H.; Jensen, Andreas I. et al.

In: Journal of Medicinal Chemistry, Vol. 58, No. 18, 24.09.2015, p. 7591-7595.

Research output: Contribution to journal › Journal article › Research › peer-review

@article{bf7af1fa34bd4ecd907f103deddcd10e,

title = "Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)",

abstract = "We present a novel solid-phase based 45Ti radiolabeling methodology and the implementation of 45Ti-PET in titanium-based antineoplastics using the showcase compound [45Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.",

author = "Severin, {Gregory W.} and Nielsen, {Carsten H.} and Jensen, {Andreas I.} and Jesper Fonslet and Andreas Kj{\ae}r and Fedor Zhuravlev",

year = "2015",

month = sep,

day = "24",

doi = "10.1021/acs.jmedchem.5b01167",

language = "English",

volume = "58",

pages = "7591--7595",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "18",

}

TY - JOUR

T1 - Bringing Radiotracing to Titanium-Based Antineoplastics

T2 - Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

AU - Severin, Gregory W.

AU - Nielsen, Carsten H.

AU - Jensen, Andreas I.

AU - Fonslet, Jesper

AU - Kjær, Andreas

AU - Zhuravlev, Fedor

PY - 2015/9/24

Y1 - 2015/9/24

N2 - We present a novel solid-phase based 45Ti radiolabeling methodology and the implementation of 45Ti-PET in titanium-based antineoplastics using the showcase compound [45Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

AB - We present a novel solid-phase based 45Ti radiolabeling methodology and the implementation of 45Ti-PET in titanium-based antineoplastics using the showcase compound [45Ti](salan)Ti(dipic). This development is intended to allow elucidation of the biodistribution and pharmacokinetics of promising new Ti-based therapeutics.

U2 - 10.1021/acs.jmedchem.5b01167

DO - 10.1021/acs.jmedchem.5b01167

M3 - Journal article

C2 - 26312993

SN - 0022-2623

VL - 58

SP - 7591

EP - 7595

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 18

ER -

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [45Ti](salan)Ti(dipic)

Abstract

Access to Document

Fingerprint

Cite this

Bringing Radiotracing to Titanium-Based Antineoplastics: Solid Phase Radiosynthesis, PET and ex Vivo Evaluation of Antitumor Agent [⁴⁵Ti](salan)Ti(dipic)