Breast cancer recurrence after reoperation for surgical bleeding

R N Pedersen; K Bhaskaran; U Heide-Jørgensen; M Nørgaard; P M Christiansen; N Kroman; H T Sørensen; D P Cronin-Fenton

doi:10.1002/bjs.10592

Breast cancer recurrence after reoperation for surgical bleeding

R N Pedersen, K Bhaskaran, U Heide-Jørgensen, M Nørgaard, P M Christiansen, N Kroman, H T Sørensen, D P Cronin-Fenton

Department of Clinical Medicine

2 Citations (Scopus)

48 Downloads (Pure)

Abstract

BACKGROUND: Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence.

METHODS: Using the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III breast cancer, who underwent breast-conserving surgery or mastectomy during 1996-2008 was identified. Information on reoperation for bleeding within 14 days of the primary surgery was retrieved from the DNPR. Follow-up began 14 days after primary surgery and continued until breast cancer recurrence, death, emigration, 10 years of follow-up, or 1 January 2013. Incidence rates of breast cancer recurrence were calculated and Cox regression models were used to quantify the association between reoperation and recurrence, adjusting for potential confounders. Crude and adjusted hazard ratios according to site of recurrence were calculated.

RESULTS: Among 30 711 patients (205 926 person-years of follow-up), 767 patients had at least one reoperation within 14 days of primary surgery, and 4769 patients developed breast cancer recurrence. Median follow-up was 7·0 years. The incidence of recurrence was 24·0 (95 per cent c.i. 20·2 to 28·6) per 1000 person-years for reoperated patients and 23·1 (22·5 to 23·8) per 1000 person-years for non-reoperated patients. The overall adjusted hazard ratio was 1·06 (95 per cent c.i. 0·89 to 1·26). The estimates did not vary by site of breast cancer recurrence.

CONCLUSION: In this large cohort study, there was no evidence of an association between reoperation for bleeding and breast cancer recurrence.

Original language	English
Journal	British Journal of Surgery
Volume	104
Issue number	12
Pages (from-to)	1665-1674
ISSN	0007-1323
DOIs	https://doi.org/10.1002/bjs.10592
Publication status	Published - Nov 2017

Keywords

Adult
Aged
Aged, 80 and over
Breast Neoplasms/surgery
Denmark/epidemiology
Female
Follow-Up Studies
Humans
Incidence
Mastectomy/adverse effects
Mastectomy, Segmental/adverse effects
Middle Aged
Neoplasm Recurrence, Local/epidemiology
Postoperative Hemorrhage/surgery
Registries
Reoperation
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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bjs.10592Final published version, 194 KBLicence: CC BY

Cite this

@article{fea4726c79ce48f884b557c14d83126a,

title = "Breast cancer recurrence after reoperation for surgical bleeding",

abstract = "BACKGROUND: Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence.METHODS: Using the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III breast cancer, who underwent breast-conserving surgery or mastectomy during 1996-2008 was identified. Information on reoperation for bleeding within 14 days of the primary surgery was retrieved from the DNPR. Follow-up began 14 days after primary surgery and continued until breast cancer recurrence, death, emigration, 10 years of follow-up, or 1 January 2013. Incidence rates of breast cancer recurrence were calculated and Cox regression models were used to quantify the association between reoperation and recurrence, adjusting for potential confounders. Crude and adjusted hazard ratios according to site of recurrence were calculated.RESULTS: Among 30 711 patients (205 926 person-years of follow-up), 767 patients had at least one reoperation within 14 days of primary surgery, and 4769 patients developed breast cancer recurrence. Median follow-up was 7·0 years. The incidence of recurrence was 24·0 (95 per cent c.i. 20·2 to 28·6) per 1000 person-years for reoperated patients and 23·1 (22·5 to 23·8) per 1000 person-years for non-reoperated patients. The overall adjusted hazard ratio was 1·06 (95 per cent c.i. 0·89 to 1·26). The estimates did not vary by site of breast cancer recurrence.CONCLUSION: In this large cohort study, there was no evidence of an association between reoperation for bleeding and breast cancer recurrence.",

keywords = "Adult, Aged, Aged, 80 and over, Breast Neoplasms/surgery, Denmark/epidemiology, Female, Follow-Up Studies, Humans, Incidence, Mastectomy/adverse effects, Mastectomy, Segmental/adverse effects, Middle Aged, Neoplasm Recurrence, Local/epidemiology, Postoperative Hemorrhage/surgery, Registries, Reoperation, Risk Factors",

author = "Pedersen, {R N} and K Bhaskaran and U Heide-J{\o}rgensen and M N{\o}rgaard and Christiansen, {P M} and N Kroman and S{\o}rensen, {H T} and Cronin-Fenton, {D P}",

note = "{\textcopyright} 2017 The Authors. BJS published by John Wiley & Sons Ltd on behalf of BJS Society Ltd.",

year = "2017",

month = nov,

doi = "10.1002/bjs.10592",

language = "English",

volume = "104",

pages = "1665--1674",

journal = "British Journal of Surgery",

issn = "0007-1323",

publisher = "JohnWiley & Sons Ltd",

number = "12",

}

TY - JOUR

T1 - Breast cancer recurrence after reoperation for surgical bleeding

AU - Pedersen, R N

AU - Bhaskaran, K

AU - Heide-Jørgensen, U

AU - Nørgaard, M

AU - Christiansen, P M

AU - Kroman, N

AU - Sørensen, H T

AU - Cronin-Fenton, D P

PY - 2017/11

Y1 - 2017/11

N2 - BACKGROUND: Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence.METHODS: Using the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III breast cancer, who underwent breast-conserving surgery or mastectomy during 1996-2008 was identified. Information on reoperation for bleeding within 14 days of the primary surgery was retrieved from the DNPR. Follow-up began 14 days after primary surgery and continued until breast cancer recurrence, death, emigration, 10 years of follow-up, or 1 January 2013. Incidence rates of breast cancer recurrence were calculated and Cox regression models were used to quantify the association between reoperation and recurrence, adjusting for potential confounders. Crude and adjusted hazard ratios according to site of recurrence were calculated.RESULTS: Among 30 711 patients (205 926 person-years of follow-up), 767 patients had at least one reoperation within 14 days of primary surgery, and 4769 patients developed breast cancer recurrence. Median follow-up was 7·0 years. The incidence of recurrence was 24·0 (95 per cent c.i. 20·2 to 28·6) per 1000 person-years for reoperated patients and 23·1 (22·5 to 23·8) per 1000 person-years for non-reoperated patients. The overall adjusted hazard ratio was 1·06 (95 per cent c.i. 0·89 to 1·26). The estimates did not vary by site of breast cancer recurrence.CONCLUSION: In this large cohort study, there was no evidence of an association between reoperation for bleeding and breast cancer recurrence.

AB - BACKGROUND: Bleeding activates platelets that can bind tumour cells, potentially promoting metastatic growth in patients with cancer. This study investigated whether reoperation for postoperative bleeding is associated with breast cancer recurrence.METHODS: Using the Danish Breast Cancer Group database and the Danish National Patient Register (DNPR), a cohort of women with incident stage I-III breast cancer, who underwent breast-conserving surgery or mastectomy during 1996-2008 was identified. Information on reoperation for bleeding within 14 days of the primary surgery was retrieved from the DNPR. Follow-up began 14 days after primary surgery and continued until breast cancer recurrence, death, emigration, 10 years of follow-up, or 1 January 2013. Incidence rates of breast cancer recurrence were calculated and Cox regression models were used to quantify the association between reoperation and recurrence, adjusting for potential confounders. Crude and adjusted hazard ratios according to site of recurrence were calculated.RESULTS: Among 30 711 patients (205 926 person-years of follow-up), 767 patients had at least one reoperation within 14 days of primary surgery, and 4769 patients developed breast cancer recurrence. Median follow-up was 7·0 years. The incidence of recurrence was 24·0 (95 per cent c.i. 20·2 to 28·6) per 1000 person-years for reoperated patients and 23·1 (22·5 to 23·8) per 1000 person-years for non-reoperated patients. The overall adjusted hazard ratio was 1·06 (95 per cent c.i. 0·89 to 1·26). The estimates did not vary by site of breast cancer recurrence.CONCLUSION: In this large cohort study, there was no evidence of an association between reoperation for bleeding and breast cancer recurrence.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Breast Neoplasms/surgery

KW - Denmark/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Mastectomy/adverse effects

KW - Mastectomy, Segmental/adverse effects

KW - Middle Aged

KW - Neoplasm Recurrence, Local/epidemiology

KW - Postoperative Hemorrhage/surgery

KW - Registries

KW - Reoperation

KW - Risk Factors

U2 - 10.1002/bjs.10592

DO - 10.1002/bjs.10592

M3 - Journal article

C2 - 28782800

SN - 0007-1323

VL - 104

SP - 1665

EP - 1674

JO - British Journal of Surgery

JF - British Journal of Surgery

IS - 12

ER -

Breast cancer recurrence after reoperation for surgical bleeding

Abstract

Keywords

UN SDGs

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