Breast Cancer in Systemic Lupus Erythematosus

B Tessier Cloutier; A E Clarke; R Ramsey-Goldman; Yu Wang; W Foulkes; C Gordon; J E Hansen; E Yelin; M B Urowitz; D Gladman; P R Fortin; D J Wallace; M Petri; S Manzi; E M Ginzler; J Labrecque; S Edworthy; M A Dooley; J L Senécal; C A Peschken; S C Bae; D Isenberg; Awahan Rahman; G Ruiz-Irastorza; J G Hanly; Søren Jacobsen; O Nived; T Witte; L A Criswell; S G Barr; L Dreyer; G Sturfelt; S Bernatsky

doi:10.1159/000353138

Breast Cancer in Systemic Lupus Erythematosus

B Tessier Cloutier, A E Clarke, R Ramsey-Goldman, Yu Wang, W Foulkes, C Gordon, J E Hansen, E Yelin, M B Urowitz, D Gladman, P R Fortin, D J Wallace, M Petri, S Manzi, E M Ginzler, J Labrecque, S Edworthy, M A Dooley, J L Senécal, C A PeschkenS C Bae, D Isenberg, Awahan Rahman, G Ruiz-Irastorza, J G Hanly, Søren Jacobsen, O Nived, T Witte, L A Criswell, S G Barr, L Dreyer, G Sturfelt, S Bernatsky

Department of Clinical Medicine

20 Citations (Scopus)

Abstract

Objective: Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries. Methods: Information on age, SLE duration, cancer date, and histology was available. We analyzed information on histological type and performed multivariate logistic regression analyses of histological types according to age, SLE duration, and calendar year. Results: We studied 180 breast cancers in the SLE cohort. Of the 155 cases with histology information, 11 were referred to simply as 'carcinoma not otherwise specified'. In the remaining 144 breast cancers, the most common histological type was ductal carcinoma (n = 95; 66%) followed by lobular adenocarcinoma (n = 11; 8%), 15 cancers were of mixed histology, and the remaining ones were special types. In our regression analyses, the independent risk factors for lobular versus ductal carcinoma was age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.01-1.14] and for the 'special' subtypes it was age (OR 1.06, 95% CI 1.01-1.10) and SLE duration (OR 1.05, 95% CI 1.00-1.11). Conclusions: Generally, up to 80% of breast cancers are ductal carcinomas. Though our results are not definitive, in the breast cancers that occur in SLE, there may be a slight decrease in the ductal histological type. In our analyses, age and SLE duration were independent predictors of histological status.

Original language	English
Journal	Oncology
Volume	85
Issue number	2
Pages (from-to)	117-21
Number of pages	5
ISSN	0030-2414
DOIs	https://doi.org/10.1159/000353138
Publication status	Published - Aug 2013

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Tessier Cloutier, B., Clarke, A. E., Ramsey-Goldman, R., Wang, Y., Foulkes, W., Gordon, C., Hansen, J. E., Yelin, E., Urowitz, M. B., Gladman, D., Fortin, P. R., Wallace, D. J., Petri, M., Manzi, S., Ginzler, E. M., Labrecque, J., Edworthy, S., Dooley, M. A., Senécal, J. L., ... Bernatsky, S. (2013). Breast Cancer in Systemic Lupus Erythematosus. Oncology, 85(2), 117-21. https://doi.org/10.1159/000353138

Tessier Cloutier, B, Clarke, AE, Ramsey-Goldman, R, Wang, Y, Foulkes, W, Gordon, C, Hansen, JE, Yelin, E, Urowitz, MB, Gladman, D, Fortin, PR, Wallace, DJ, Petri, M, Manzi, S, Ginzler, EM, Labrecque, J, Edworthy, S, Dooley, MA, Senécal, JL, Peschken, CA, Bae, SC, Isenberg, D, Rahman, A, Ruiz-Irastorza, G, Hanly, JG, Jacobsen, S, Nived, O, Witte, T, Criswell, LA, Barr, SG, Dreyer, L, Sturfelt, G & Bernatsky, S 2013, 'Breast Cancer in Systemic Lupus Erythematosus', Oncology, vol. 85, no. 2, pp. 117-21. https://doi.org/10.1159/000353138

@article{cb914d813a844cbd91d0caa7472dece0,

title = "Breast Cancer in Systemic Lupus Erythematosus",

abstract = "Objective: Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries. Methods: Information on age, SLE duration, cancer date, and histology was available. We analyzed information on histological type and performed multivariate logistic regression analyses of histological types according to age, SLE duration, and calendar year. Results: We studied 180 breast cancers in the SLE cohort. Of the 155 cases with histology information, 11 were referred to simply as 'carcinoma not otherwise specified'. In the remaining 144 breast cancers, the most common histological type was ductal carcinoma (n = 95; 66%) followed by lobular adenocarcinoma (n = 11; 8%), 15 cancers were of mixed histology, and the remaining ones were special types. In our regression analyses, the independent risk factors for lobular versus ductal carcinoma was age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.01-1.14] and for the 'special' subtypes it was age (OR 1.06, 95% CI 1.01-1.10) and SLE duration (OR 1.05, 95% CI 1.00-1.11). Conclusions: Generally, up to 80% of breast cancers are ductal carcinomas. Though our results are not definitive, in the breast cancers that occur in SLE, there may be a slight decrease in the ductal histological type. In our analyses, age and SLE duration were independent predictors of histological status.",

author = "{Tessier Cloutier}, B and Clarke, {A E} and R Ramsey-Goldman and Yu Wang and W Foulkes and C Gordon and Hansen, {J E} and E Yelin and Urowitz, {M B} and D Gladman and Fortin, {P R} and Wallace, {D J} and M Petri and S Manzi and Ginzler, {E M} and J Labrecque and S Edworthy and Dooley, {M A} and Sen{\'e}cal, {J L} and Peschken, {C A} and Bae, {S C} and D Isenberg and Awahan Rahman and G Ruiz-Irastorza and Hanly, {J G} and S{\o}ren Jacobsen and O Nived and T Witte and Criswell, {L A} and Barr, {S G} and L Dreyer and G Sturfelt and S Bernatsky",

year = "2013",

month = aug,

doi = "10.1159/000353138",

language = "English",

volume = "85",

pages = "117--21",

journal = "Oncology",

issn = "0030-2414",

publisher = "S Karger AG",

number = "2",

}

TY - JOUR

T1 - Breast Cancer in Systemic Lupus Erythematosus

AU - Tessier Cloutier, B

AU - Clarke, A E

AU - Ramsey-Goldman, R

AU - Wang, Yu

AU - Foulkes, W

AU - Gordon, C

AU - Hansen, J E

AU - Yelin, E

AU - Urowitz, M B

AU - Gladman, D

AU - Fortin, P R

AU - Wallace, D J

AU - Petri, M

AU - Manzi, S

AU - Ginzler, E M

AU - Labrecque, J

AU - Edworthy, S

AU - Dooley, M A

AU - Senécal, J L

AU - Peschken, C A

AU - Bae, S C

AU - Isenberg, D

AU - Rahman, Awahan

AU - Ruiz-Irastorza, G

AU - Hanly, J G

AU - Jacobsen, Søren

AU - Nived, O

AU - Witte, T

AU - Criswell, L A

AU - Barr, S G

AU - Dreyer, L

AU - Sturfelt, G

AU - Bernatsky, S

PY - 2013/8

Y1 - 2013/8

N2 - Objective: Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries. Methods: Information on age, SLE duration, cancer date, and histology was available. We analyzed information on histological type and performed multivariate logistic regression analyses of histological types according to age, SLE duration, and calendar year. Results: We studied 180 breast cancers in the SLE cohort. Of the 155 cases with histology information, 11 were referred to simply as 'carcinoma not otherwise specified'. In the remaining 144 breast cancers, the most common histological type was ductal carcinoma (n = 95; 66%) followed by lobular adenocarcinoma (n = 11; 8%), 15 cancers were of mixed histology, and the remaining ones were special types. In our regression analyses, the independent risk factors for lobular versus ductal carcinoma was age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.01-1.14] and for the 'special' subtypes it was age (OR 1.06, 95% CI 1.01-1.10) and SLE duration (OR 1.05, 95% CI 1.00-1.11). Conclusions: Generally, up to 80% of breast cancers are ductal carcinomas. Though our results are not definitive, in the breast cancers that occur in SLE, there may be a slight decrease in the ductal histological type. In our analyses, age and SLE duration were independent predictors of histological status.

AB - Objective: Evidence points to a decreased breast cancer risk in systemic lupus erythematosus (SLE). We analyzed data from a large multisite SLE cohort, linked to cancer registries. Methods: Information on age, SLE duration, cancer date, and histology was available. We analyzed information on histological type and performed multivariate logistic regression analyses of histological types according to age, SLE duration, and calendar year. Results: We studied 180 breast cancers in the SLE cohort. Of the 155 cases with histology information, 11 were referred to simply as 'carcinoma not otherwise specified'. In the remaining 144 breast cancers, the most common histological type was ductal carcinoma (n = 95; 66%) followed by lobular adenocarcinoma (n = 11; 8%), 15 cancers were of mixed histology, and the remaining ones were special types. In our regression analyses, the independent risk factors for lobular versus ductal carcinoma was age [odds ratio (OR) 1.07, 95% confidence interval (CI) 1.01-1.14] and for the 'special' subtypes it was age (OR 1.06, 95% CI 1.01-1.10) and SLE duration (OR 1.05, 95% CI 1.00-1.11). Conclusions: Generally, up to 80% of breast cancers are ductal carcinomas. Though our results are not definitive, in the breast cancers that occur in SLE, there may be a slight decrease in the ductal histological type. In our analyses, age and SLE duration were independent predictors of histological status.

U2 - 10.1159/000353138

DO - 10.1159/000353138

M3 - Journal article

C2 - 23887245

SN - 0030-2414

VL - 85

SP - 117

EP - 121

JO - Oncology

JF - Oncology

IS - 2

ER -

Breast Cancer in Systemic Lupus Erythematosus

Abstract

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