Brain tumor imaging using small-angle x-ray scattering tomography

Torben Haugaard Jensen; Martin Bech; Oliver Bunk; Maria Thomsen; Andreas Menzel; Audrey Bouchet; G. Le Duc; Robert Krarup Feidenhans'l; Franz Pfeffer

doi:10.1088/0031-9155/56/6/012

Brain tumor imaging using small-angle x-ray scattering tomography

Torben Haugaard Jensen, Martin Bech, Oliver Bunk, Maria Thomsen, Andreas Menzel, Audrey Bouchet, G. Le Duc, Robert Krarup Feidenhans'l, Franz Pfeffer

36 Citations (Scopus)

Abstract

We demonstrate high-resolution small-angle x-ray scattering computed tomography (SAXS-CT) of soft matter and soft tissue samples. Complete SAXS patterns over extended ranges of momentum transfer are reconstructed spatially resolved from volumes inside an extended sample. Several SAXS standard samples are used to quantitatively validate the method and demonstrate its performance. Further results on biomedical tissue samples (rat brains) are presented that demonstrate the advantages of the method compared to existing biomedical x-ray imaging approaches. Functional areas of the brains as well as tumor morphology are imaged. By providing insights into the structural organization at the nano-level, SAXS-CT complements and extends results obtainable with standard methods such as x-ray absorption tomography and histology.

Original language	English
Journal	Physics in Medicine and Biology
Volume	56
Issue number	6
Pages (from-to)	1717-1726
ISSN	0031-9155
DOIs	https://doi.org/10.1088/0031-9155/56/6/012
Publication status	Published - 21 Mar 2011

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title = "Brain tumor imaging using small-angle x-ray scattering tomography",

abstract = "We demonstrate high-resolution small-angle x-ray scattering computed tomography (SAXS-CT) of soft matter and soft tissue samples. Complete SAXS patterns over extended ranges of momentum transfer are reconstructed spatially resolved from volumes inside an extended sample. Several SAXS standard samples are used to quantitatively validate the method and demonstrate its performance. Further results on biomedical tissue samples (rat brains) are presented that demonstrate the advantages of the method compared to existing biomedical x-ray imaging approaches. Functional areas of the brains as well as tumor morphology are imaged. By providing insights into the structural organization at the nano-level, SAXS-CT complements and extends results obtainable with standard methods such as x-ray absorption tomography and histology.",

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AU - Jensen, Torben Haugaard

AU - Bech, Martin

AU - Bunk, Oliver

AU - Thomsen, Maria

AU - Menzel, Andreas

AU - Bouchet, Audrey

AU - Le Duc, G.

AU - Feidenhans'l, Robert Krarup

AU - Pfeffer, Franz

PY - 2011/3/21

Y1 - 2011/3/21

N2 - We demonstrate high-resolution small-angle x-ray scattering computed tomography (SAXS-CT) of soft matter and soft tissue samples. Complete SAXS patterns over extended ranges of momentum transfer are reconstructed spatially resolved from volumes inside an extended sample. Several SAXS standard samples are used to quantitatively validate the method and demonstrate its performance. Further results on biomedical tissue samples (rat brains) are presented that demonstrate the advantages of the method compared to existing biomedical x-ray imaging approaches. Functional areas of the brains as well as tumor morphology are imaged. By providing insights into the structural organization at the nano-level, SAXS-CT complements and extends results obtainable with standard methods such as x-ray absorption tomography and histology.

AB - We demonstrate high-resolution small-angle x-ray scattering computed tomography (SAXS-CT) of soft matter and soft tissue samples. Complete SAXS patterns over extended ranges of momentum transfer are reconstructed spatially resolved from volumes inside an extended sample. Several SAXS standard samples are used to quantitatively validate the method and demonstrate its performance. Further results on biomedical tissue samples (rat brains) are presented that demonstrate the advantages of the method compared to existing biomedical x-ray imaging approaches. Functional areas of the brains as well as tumor morphology are imaged. By providing insights into the structural organization at the nano-level, SAXS-CT complements and extends results obtainable with standard methods such as x-ray absorption tomography and histology.

U2 - 10.1088/0031-9155/56/6/012

DO - 10.1088/0031-9155/56/6/012

M3 - Journal article

C2 - 21346275

SN - 0031-9155

VL - 56

SP - 1717

EP - 1726

JO - Physics in Medicine and Biology

JF - Physics in Medicine and Biology

IS - 6

ER -

Brain tumor imaging using small-angle x-ray scattering tomography

Abstract

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