Brain serotonin 4 receptor binding is inversely associated with verbal memory recall

TY - JOUR

T1 - Brain serotonin 4 receptor binding is inversely associated with verbal memory recall

AU - Stenbæk, Dea S

AU - Fisher, Patrick M

AU - Ozenne, Brice

AU - Andersen, Emil

AU - Hjordt, Liv V

AU - McMahon, Brenda

AU - Hasselbalch, Steen G

AU - Frokjaer, Vibe G

AU - Knudsen, Gitte M

PY - 2017/4

Y1 - 2017/4

N2 - BACKGROUND: We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5-HT 4R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5-HT 4R binding and affective verbal memory recall.METHODS: Twenty-four healthy volunteers were scanned with the 5-HT 4R radioligand [11C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Test-24. The association between 5-HT 4R binding and affective verbal memory was evaluated using a linear latent variable structural equation model.RESULTS: We observed a significant inverse association across all regions between 5-HT 4R binding and affective verbal memory performances for positive (p = 5.5 × 10-4) and neutral (p = .004) word recall, and an inverse but nonsignificant association for negative (p = .07) word recall. Differences in the associations with 5-HT 4R binding between word categories (i.e., positive, negative, and neutral) did not reach statistical significance.CONCLUSION: Our findings replicate our previous observation of a negative association between 5-HT 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT 4R binding, as a biomarker for synaptic 5-HT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans.

AB - BACKGROUND: We have previously identified an inverse relationship between cerebral serotonin 4 receptor (5-HT 4R) binding and nonaffective episodic memory in healthy individuals. Here, we investigate in a novel sample if the association is related to affective components of memory, by examining the association between cerebral 5-HT 4R binding and affective verbal memory recall.METHODS: Twenty-four healthy volunteers were scanned with the 5-HT 4R radioligand [11C]SB207145 and positron emission tomography, and were tested with the Verbal Affective Memory Test-24. The association between 5-HT 4R binding and affective verbal memory was evaluated using a linear latent variable structural equation model.RESULTS: We observed a significant inverse association across all regions between 5-HT 4R binding and affective verbal memory performances for positive (p = 5.5 × 10-4) and neutral (p = .004) word recall, and an inverse but nonsignificant association for negative (p = .07) word recall. Differences in the associations with 5-HT 4R binding between word categories (i.e., positive, negative, and neutral) did not reach statistical significance.CONCLUSION: Our findings replicate our previous observation of a negative association between 5-HT 4R binding and memory performance in an independent cohort and provide novel evidence linking 5-HT 4R binding, as a biomarker for synaptic 5-HT levels, to the mnestic processing of positive and neutral word stimuli in healthy humans.

KW - Adult

KW - Brain/diagnostic imaging

KW - Emotions/physiology

KW - Female

KW - Humans

KW - Male

KW - Mental Recall/physiology

KW - Middle Aged

KW - Neuropsychological Tests

KW - Piperidines

KW - Positron-Emission Tomography

KW - Radiopharmaceuticals

KW - Receptors, Serotonin, 5-HT4/metabolism

KW - Speech Perception/physiology

KW - Young Adult

U2 - 10.1002/brb3.674

DO - 10.1002/brb3.674

M3 - Journal article

C2 - 28413715

SN - 2157-9032

VL - 7

JO - Brain and Behavior

JF - Brain and Behavior

IS - 4

M1 - e00674

ER -