Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men

Morten Sejer Hansen; Lino Becerra; Jørgen Berg Dahl; David Borsook; Johan Mårtensson; Anders Christensen; Janus Damm Nybing; Inger Havsteen; Mikael Boesen; Mohammad Sohail Asghar

doi:10.1007/s00429-018-01819-z

Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men

Morten Sejer Hansen^*, Lino Becerra, Jørgen Berg Dahl, David Borsook, Johan Mårtensson, Anders Christensen, Janus Damm Nybing, Inger Havsteen, Mikael Boesen, Mohammad Sohail Asghar

^*Corresponding author for this work

Department of Clinical Medicine

1 Citation (Scopus)

Abstract

Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We recruited 121 healthy participants (male, age 22, SD 3.35) who underwent resting-state functional magnetic resonance imaging. Prior to the scan session, areas of secondary hyperalgesia following brief thermal sensitization (3 min. 45 °C heat stimulation) were evaluated in all participants. 115 participants were included in the final analysis. We found a positive correlation (increasing connectivity) with increasing area of secondary hyperalgesia in the sensorimotor- and default mode networks. We also observed a negative correlation (decreasing connectivity) with increasing secondary hyperalgesia area in the sensorimotor-, fronto-parietal-, and default mode networks. Our findings indicate that increasing area of secondary hyperalgesia is associated with increasing and decreasing connectivity in multiple networks, suggesting that differences in the propensity for central sensitization, assessed as secondary hyperalgesia areas, may be expressed as differences in the resting-state central neuronal activity.

Original language	English
Journal	Brain Structure and Function
Volume	224
Issue number	3
Pages (from-to)	1119-1139
Number of pages	21
ISSN	1863-2653
DOIs	https://doi.org/10.1007/s00429-018-01819-z
Publication status	Published - 2019

Keywords

Central sensitization
MRI
Pain
Resting-state fMRI
Secondary hyperalgesia

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10.1007/s00429-018-01819-z

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title = "Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men",

abstract = "Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We recruited 121 healthy participants (male, age 22, SD 3.35) who underwent resting-state functional magnetic resonance imaging. Prior to the scan session, areas of secondary hyperalgesia following brief thermal sensitization (3 min. 45 °C heat stimulation) were evaluated in all participants. 115 participants were included in the final analysis. We found a positive correlation (increasing connectivity) with increasing area of secondary hyperalgesia in the sensorimotor- and default mode networks. We also observed a negative correlation (decreasing connectivity) with increasing secondary hyperalgesia area in the sensorimotor-, fronto-parietal-, and default mode networks. Our findings indicate that increasing area of secondary hyperalgesia is associated with increasing and decreasing connectivity in multiple networks, suggesting that differences in the propensity for central sensitization, assessed as secondary hyperalgesia areas, may be expressed as differences in the resting-state central neuronal activity.",

keywords = "Central sensitization, MRI, Pain, Resting-state fMRI, Secondary hyperalgesia",

author = "Hansen, {Morten Sejer} and Lino Becerra and Dahl, {J{\o}rgen Berg} and David Borsook and Johan M{\aa}rtensson and Anders Christensen and Nybing, {Janus Damm} and Inger Havsteen and Mikael Boesen and Asghar, {Mohammad Sohail}",

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AU - Hansen, Morten Sejer

AU - Becerra, Lino

AU - Dahl, Jørgen Berg

AU - Borsook, David

AU - Mårtensson, Johan

AU - Christensen, Anders

AU - Nybing, Janus Damm

AU - Havsteen, Inger

AU - Boesen, Mikael

AU - Asghar, Mohammad Sohail

PY - 2019

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N2 - Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We recruited 121 healthy participants (male, age 22, SD 3.35) who underwent resting-state functional magnetic resonance imaging. Prior to the scan session, areas of secondary hyperalgesia following brief thermal sensitization (3 min. 45 °C heat stimulation) were evaluated in all participants. 115 participants were included in the final analysis. We found a positive correlation (increasing connectivity) with increasing area of secondary hyperalgesia in the sensorimotor- and default mode networks. We also observed a negative correlation (decreasing connectivity) with increasing secondary hyperalgesia area in the sensorimotor-, fronto-parietal-, and default mode networks. Our findings indicate that increasing area of secondary hyperalgesia is associated with increasing and decreasing connectivity in multiple networks, suggesting that differences in the propensity for central sensitization, assessed as secondary hyperalgesia areas, may be expressed as differences in the resting-state central neuronal activity.

AB - Central sensitization is a condition in which there is an abnormal responsiveness to nociceptive stimuli. As such, the process may contribute to the development and maintenance of pain. Factors influencing the propensity for development of central sensitization have been a subject of intense debate and remain elusive. Injury-induced secondary hyperalgesia can be elicited by experimental pain models in humans, and is believed to be a result of central sensitization. Secondary hyperalgesia may thus reflect the individual level of central sensitization. The objective of this study was to investigate possible associations between increasing size of secondary hyperalgesia area and brain connectivity in known resting-state networks. We recruited 121 healthy participants (male, age 22, SD 3.35) who underwent resting-state functional magnetic resonance imaging. Prior to the scan session, areas of secondary hyperalgesia following brief thermal sensitization (3 min. 45 °C heat stimulation) were evaluated in all participants. 115 participants were included in the final analysis. We found a positive correlation (increasing connectivity) with increasing area of secondary hyperalgesia in the sensorimotor- and default mode networks. We also observed a negative correlation (decreasing connectivity) with increasing secondary hyperalgesia area in the sensorimotor-, fronto-parietal-, and default mode networks. Our findings indicate that increasing area of secondary hyperalgesia is associated with increasing and decreasing connectivity in multiple networks, suggesting that differences in the propensity for central sensitization, assessed as secondary hyperalgesia areas, may be expressed as differences in the resting-state central neuronal activity.

KW - Central sensitization

KW - MRI

KW - Pain

KW - Resting-state fMRI

KW - Secondary hyperalgesia

U2 - 10.1007/s00429-018-01819-z

DO - 10.1007/s00429-018-01819-z

M3 - Journal article

C2 - 30631932

AN - SCOPUS:85059853528

SN - 1863-2653

VL - 224

SP - 1119

EP - 1139

JO - Brain Structure and Function

JF - Brain Structure and Function

IS - 3

ER -

Brain resting-state connectivity in the development of secondary hyperalgesia in healthy men

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Keywords

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