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Both Reactivity and Accessibility Are Important in Cytochrome P450 Metabolism: A Combined DFT and MD Study of Fenamic Acids in BM3 Mutants
Rasmus Leth, Bogac Ercig, Lars Olsen,
Flemming Steen Jørgensen
6
Citations (Scopus)
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Dive into the research topics of 'Both Reactivity and Accessibility Are Important in Cytochrome P450 Metabolism: A Combined DFT and MD Study of Fenamic Acids in BM3 Mutants'. Together they form a unique fingerprint.
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Immunology and Microbiology
Hydroxylation
100%
Cytochrome P450
100%
Dynamics
100%
Monooxygenase
50%
Point Mutation
50%
Drug Metabolism
50%
Bacillus Megaterium
50%
Metabolite
50%
Computer Simulation
50%
Chemistry
Fenamic Acid
100%
Aromatic Hydroxylation
50%
Mefenamic Acid
50%
Meclofenamic Acid
50%
Tolfenamic Acid
50%
Keyphrases
Fenamic Acids
100%
Fatty Acid 2-hydroxylase
25%
Meclofenamic Acid
25%
Aromatic Hydroxylation
25%
Aliphatic Hydroxylation
25%
Pharmacology, Toxicology and Pharmaceutical Science
Meclofenamic Acid
33%
Cytochrome P450 BM3
33%